Silverman, Scott K. - University of Illinois at Urbana-Champaign

个人简介

Professor Silverman received the B.S. degree in chemistry from UCLA in 1991. He obtained the Ph.D. degree in chemistry from Caltech in 1997, working with Dennis Dougherty on physical organic chemistry and molecular neurobiology, and he performed postdoctoral research with Thomas Cech at the University of Colorado at Boulder. He joined the faculty at the University of Illinois in 2000, working in the areas of chemical biology and organic chemistry.

近期论文

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"Pursuing DNA Catalysts for Protein Modification", S. K. Silverman, Acc. Chem. Res. 2015, 48, submitted for publication. "A Modular Tyrosine Kinase Deoxyribozyme with Discrete Aptamer and Catalyst Domains", V. Dokukin and S. K. Silverman, Chem. Commun. 2014, 50, 9317-9320. "DNA-Catalyzed Lysine Side Chain Modification", B. M. Brandsen, T. E. Velez, A. Sachdeva, N. A. Ibrahim, and S. K. Silverman, Angew. Chem. Int. Ed. 2014, 53, 9045-9050. "A Generalizable DNA-Catalyzed Approach to Peptide-Nucleic Acid Conjugation", C. Chu, O. Wong, and S. K. Silverman, ChemBioChem 2014, 15, 1905-1910. "DNA-Catalyzed Hydrolysis of Esters and Aromatic Amides", B. M. Brandsen, A. R. Hesser, M. A. Castner, M. Chandra, and S. K. Silverman, J. Am. Chem. Soc. 2013, 135, 16014-16017. "DNA Catalysts with Tyrosine Kinase Activity", S. M. Walsh, A. Sachdeva, and S. K. Silverman, J. Am. Chem. Soc. 2013, 135, 14928-14931. "DNA Catalysis of a Normally Disfavored RNA Hydrolysis Reaction", D. J. Parker, Y. Xiao, J. M. Aguilar, and S. K. Silverman, J. Am. Chem. Soc. 2013, 135, 8472-8475. "Catalytic DNA with Phosphatase Activity", J. Chandrasekar and S. K. Silverman, Proc. Natl. Acad. Sci. USA 2013, 110, 5315-5320. "Systematic Evaluation of the Dependence of Deoxyribozyme Catalysis on Random Region Length", T. E. Velez, J. Singh, Y. Xiao, E. C. Allen, O. Wong, M. Chandra, S. C. Kwon, and S. K. Silverman, ACS Comb. Sci. 2012, 14, 680-687. "Shields for Small Molecules", S. K. Silverman, Nat. Chem. 2012, 4, 774-775. "Covalent Tagging of Phosphorylated Peptides By Phosphate-Specific Deoxyribozymes", A. Sachdeva, M. Chandra, J. Chandrasekar, and S. K. Silverman, ChemBioChem 2012, 13, 654-657. "Lanthanide Ions as Required Cofactors for DNA Catalysts", V. Dokukin and S. K. Silverman, Chem. Sci. 2012, 3, 1707-1714. "Establishing Broad Generality of DNA Catalysts for Site-Specific Hydrolysis of Single-Stranded DNA", Y. Xiao, R. J. Wehrmann, N. A. Ibrahim, and S. K. Silverman, Nucleic Acids Res. 2012, 40, 1778-1786. "DNA-Catalyzed Reactivity of a Phosphoramidate Functional Group and Formation of an Unusual Pyrophosphoramidate Linkage", A. Sachdeva and S. K. Silverman, Org. Biomol. Chem. 2012, 10, 122-125. "DNA-Catalyzed Reductive Amination", O. Wong, A. E. Mulcrone, and S. K. Silverman, Angew. Chem. Int. Ed. 2011, 50, 11679-11684. "DNA-Catalyzed Covalent Modification of Amino Acid Side Chains in Tethered and Free Peptide Substrates", O. Wong, P. I. Pradeepkumar, and S. K. Silverman, Biochemistry 2011, 50, 4741-4749. "Merely Two Mutations Switch a DNA-Hydrolyzing Deoxyribozyme from Heterobimetallic (Zn2+/Mn2+) to Monometallic (Zn2+-only) Behavior", Y. Xiao, E. C. Allen, and S. K. Silverman, Chem. Commun. 2011, 47, 1749-1751. "Improved Deoxyribozymes for Synthesis of Covalently Branched DNA and RNA", C. S. Lee, T. P. Mui, and S. K. Silverman, Nucleic Acids Res. 2011, 39, 269-279. "Functional Compromises Among pH Tolerance, Site Specificity, and Sequence Tolerance for a DNA-Hydrolyzing Deoxyribozyme", Y. Xiao, M. Chandra, and S. K. Silverman, Biochemistry 2010, 49, 9630-9637. "DNA-Catalyzed Serine Side Chain Reactivity and Selectivity", A. Sachdeva and S. K. Silverman, Chem. Commun. 2010, 46, 2215-2217.