研究领域
(1) 有机(黄酮类、天然有机化合物，碳纳米管)、无机分子(NaNO2)与蛋白质的相互作用及其化学生物学效应；
(2) 氨基酸翻译后修饰与蛋白质结构和功能、以及疾病发生发展的关系。
近期论文
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1. Naihao Lu*, Jiayu Li, Zhonghong Gao*. Key roles of Tyr 10 in Cu bound Aβ complexes and its relevance to Alzheimer's disease. Archives of Biochemistry and Biophysics. 2015, 584: 1-9.
2. Naihao Lu*, Jiayu Li, Xiaoming Ren, Rong Tian, Yi-Yuan Peng*. Nitrite attenuated hypochlorous acid-mediated heme degradation in hemoglobin. Chemico-Biological Interactions. 2015, 238: 25-32.
3. Naihao Lu*, Shiliang Xie, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Myeloperoxidase-mediated oxidation targets serum apolipoprotein A-I in diabetic patients and represents a potential mechanism leading to impaired anti-apoptotic activity of high density lipoprotein. Clinica Chimica Acta. 2015, 441: 163-170.
4. Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Key roles for tyrosine 10 in Aβ-heme complexes and its relevance to oxidative stress. Chemical Research in Toxicology. 2015, 28(3): 365-372.
5. Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Key roles of Arg5, Tyr10 and His residues in Aβ-heme peroxidase: Relevance to Alzheimer's disease. Biochemical and Biophysical Research Communications. 2014, 452(3): 676-681.
6. Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Binding of human serum albumin to single-walled carbon nanotubes activated neutrophils to increase production of hypochlorous acid, the oxidant capable of degrading nanotubes. Chemical Research in Toxicology. 2014, 27(6): 1070-1077.
7. Naihao Lu*, Jiayu Li, Yingjie He, Rong Tian, Qiang Xiao*. Nitrative modifications of α-enolase in hepatic proteins from diabetic rats: The involvement of myeloperoxidase. Chemico-Biological Interactions. 2014, 220: 12-19.
8. Naihao Lu*, Chao Chen, Yingjie He, Rong Tian, Qiang Xiao, Yi-Yuan Peng*. The dual effects of nitrite on hemoglobin-dependent redox reactions. Nitric Oxide. 2014, 40: 1-9.
9. Naihao Lu*, Yingjie He, Chao Chen, Rong Tian, Qiang Xiao*, Yi-Yuan Peng. Tyrosine can protect against oxidative stress through ferryl hemoglobin reduction. Toxicology in Vitro. 2014, 28(5): 847-855.
10. Naihao Lu, Lian Yi, Qinqin Deng, Jinyang Li, Zhonghong Gao, Hailing Li*. The interaction between desferrioxamine and hemin: a potential toxicological implication. Toxicology in Vitro. 2012, 26 (5): 732-735.
11. Naihao Lu*, Wei Chen, Jingjie Zhu, Yi-Yuan Peng*. Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication. Toxicology in Vitro. 2012, 26 (1): 81-85.
12. Naihao Lu, Wei Chen, Yi-Yuan Peng*. Effects of glutathione, Trolox and desferrioxamine on hemoglobin-induced protein oxidative damage: anti-oxidant or pro-oxidant? European Journal of Pharmacology. 2011, 659 (2-3): 95-101.
13. Naihao Lu, Puqing Chen, Qin Yang, Yi-Yuan Peng*. Anti- and pro-oxidant effects of (+)-catechin on hemoglobin-induced protein oxidative damage. Toxicology in Vitro. 2011, 25 (4): 833-838.
14. Naihao Lu, Xueli Li, Jinyang Li, Wenjing Xu, Hailing Li, Zhonghong Gao*. Nitrative and oxidative modifications of enolase are associated with iron in iron overload rats and in vitro. Journal of Biological Inorganic Chemistry. 2011, 16(3): 481-490.
15. Naihao Lu, Yan Zhang, Hailing Li, Zhonghong Gao*. Oxidative and nitrative modifications of α-enolase in cardiac proteins from diabetic rats. Free Radical Biology & Medicine. 2010, 48 (7): 873-881.
16. Naihao Lu, Goufeng Zhou, Di Pei, Lian Yi, Zhonghong Gao*. Peroxynitrite and heme protein - mediated nitrative/oxidative modification of human plasma protein: The role of free radical scavenging vs. complex forming. Toxicology in Vitro. 2009, 23 (7): 1227-1233.
17. Naihao Lu, Yan Zhang, Zhonghong Gao*. Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. Toxicology in Vitro. 2009, 23 (4): 627-633.
18. Naihao Lu, Mingyi Zhang, Hailing Li, Zhonghong Gao*. Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Chemical Research in Toxicology. 2008, 21(6): 1229-1234.
19. Naihao Lu, Zhening Zhu, Xuqi Zhao, Ran Tao, Xiangliang Yang, Zhonghong Gao*. Nano titanium dioxide photocatalytic protein tyrosine nitration: a potential hazard of TiO2 on skin. Biochemical and Biophysical Research Communications. 2008, 370(4): 675-680.
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