个人简介

Ph.D. | Biochemistry (Structural Enzymology) | University of Wisconsin at Madison 1995 B.Sc. | Biochemistry (Magna Cum Laude) | University of California at Riverside 1990

研究领域

Catalytic Strategies of Ribozymes

The Wedekind lab investigates the mechanisms of action of non-protein-coding (nc)RNAs. Our goal is to understand the principles by which these molecules gain biological function, which is widely applicable to human disease, as well as the identification of new antimicrobial targets. Model systems include small ribozymes derived from plant viroids, and metabolite sensing riboswitches from bacteria that regulate gene expression. This work is funded by NIH/NIGMS grant R01 GM063162.

近期论文

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2014 Jun 4 Heldenbrand H, Janowski PA, Giamba?u G, Giese TJ, Wedekind JE, York DM. "Evidence for the role of active site residues in the hairpin ribozyme from molecular simulations along the reaction path." Journal of the American Chemical Society. 2014 Jun 4; 136(22):7789-92. Epub 2014 May 23. Liberman JA, Bogue JT, Jenkins JL, Salim M, Wedekind JE. "ITC analysis of ligand binding to preQ? riboswitches." Methods in enzymology. 2014 549:435-50. 2013 Sep 23 Can M, Krucinska J, Zoppellaro G, Andersen NH, Wedekind JE, Hersleth HP, Andersson KK, Bren KL. "Structural characterization of nitrosomonas europaea cytochrome c-552 variants with marked differences in electronic structure." Chembiochem : a European journal of chemical biology. 2013 Sep 23; 14(14):1828-38. Epub 2013 Jul 31. 2013 Jun Liberman JA, Salim M, Krucinska J, Wedekind JE. "Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold." Nature chemical biology. 2013 Jun; 9(6):353-5. Epub 2013 Apr 14. 2013 Feb 5 Wang W, Maucuer A, Gupta A, Manceau V, Thickman KR, Bauer WJ, Kennedy SD, Wedekind JE, Green MR, Kielkopf CL. "Structure of phosphorylated SF1 bound to U2AF?? in an essential splicing factor complex." Structure. 2013 Feb 5; 21(2):197-208. Epub 2012 Dec 27.