个人简介

PhD | Organic Chemistry | Stanford University 1994 BS, Chemistry; B.A. Mathematics; B.A. German | Miami University 1988

研究领域

Developing new strategies for the sequence-selective recognition of RNA/and using the optical properties of nanostructured materials for the production of novel biosensors

Research in the Miller group focuses on two fundamental areas: the control of biomolecular interactions through the synthesis of new small-molecule probes, and the observation of biomolecular interactions through the development of novel optical sensing technologies. In the area of control, we are particularly interested in the sequence-selective recognition of RNA. New RNA sequences with important functions in basic biology and human health and disease are being discovered at an ever-increasing rate, and yet our ability to target these sequences specifically is still at a rudimentary stage. To address this gap, we are applying techniques of molecular design and a novel combinatorial method of small-molecule evolution called Dynamic Combinatorial Chemistry, which allows us to rapidly "prototype"

近期论文

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2015 Feb 3 Baker JE, Sriram R, Miller BL. "Two-dimensional photonic crystals for sensitive microscale chemical and biochemical sensing." Lab on a chip. 2015 Feb 3; 15(4):971-90. 2014 Oct 1 Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe JI. "Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Oct 1; 193(7):3803-15. Epub 2014 Sep 03. 2014 Feb 13 Ofori LO, Hilimire TA, Bennett RP, Brown NW, Smith HC, Miller BL. "High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity." Journal of medicinal chemistry. 2014 Feb 13; 57(3):723-32. Epub 2014 Jan 15. 2014 Feb 1 Yadav AR, Sriram R, Carter JA, Miller BL. "Comparative study of solution-phase and vapor-phase deposition of aminosilanes on silicon dioxide surfaces." Materials science & engineering. C, Materials for biological applications. 2014 Feb 1; 35:283-90. Epub 2013 Nov 20. 2014 Jan 21 Lifson MA, Basu Roy D, Miller BL. "Enhancing the detection limit of nanoscale biosensors via topographically selective functionalization." Analytical chemistry. 2014 Jan 21; 86(2):1016-22. Epub 2013 Dec 27.