Mathews, David H. - University of Rochester

个人简介

研究领域

Predicting RNA Secondary Structure

Our understanding of the role of RNA in cellular processes has expanded enormously over the last two decades. Originally, RNA was understood to participate in protein expression as a carrier of genetic information (mRNA) and as an adapter molecule (tRNA) for reading the code. Then RNA was discovered to catalyze reactions, including self-splicing, phosphodiester bond cleavage, and peptide bond formation. RNA is now known to play functions in diverse cellular processes, such as development, immunity, RNA editing and modification, and post-transcriptional gene regulation. RNA is also an important player in many diseases, including Prader-Willi, b-thalassemia, and myotonic dystrophy. RNA sequences can be evolved in vitro to catalyze many reactions that are not part of the natural repertoire. Antisense and RNAi can be used to modulate gene expression.

近期论文

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Sloma MF, Mathews DH. "Improving RNA secondary structure prediction with structure mapping data." Methods in enzymology. 2015 553:91-114. Epub 2015 Feb 03. 2014 Aug 1 Guy MP, Young DL, Payea MJ, Zhang X, Kon Y, Dean KM, Grayhack EJ, Mathews DH, Fields S, Phizicky EM. "Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis." Genes & development. 2014 Aug 1; 28(15):1721-32. 2014 Mar 11 Aytenfisu AH, Spasic A, Seetin MG, Serafini J, Mathews DH. "Modified Amber Force Field Correctly Models the Conformational Preference for Tandem GA pairs in RNA." Journal of chemical theory and computation. 2014 Mar 11; 10(3):1292-1301. Epub 2014 Jan 22. Fu Y, Sharma G, Mathews DH. "Dynalign II: common secondary structure prediction for RNA homologs with domain insertions." Nucleic acids research. 2014 42(22):13939-48. Mathews DH. "Using the RNAstructure Software Package to Predict Conserved RNA Structures." Current protocols in bioinformatics. 2014 46:12.4.1-12.4.22. Epub 2014 Jun 17.