Sarlah, David - University of Illinois at Urbana-Champaign

个人简介

10/2014 Assistant Professor of Chemistry, UIUC 11/2011 – 07/2014 Postdoctoral research, ETH Zürich 09/2006 – 09/2011 Ph.D. The Scripps Research Institute, CA David was born and raised in Slovenia, where he obtained his Bachelor’s Degree in Chemistry (University of Ljubljana). He carried out his undergraduate research with Prof. K. C. Nicolaou at Scripps and Prof. Samuel J. Danishefsky at Columbia. He obtained his Ph.D. in chemistry with Prof. K. C. Nicolaou involving the total synthesis of complex natural products. David then joined Prof. Erick M. Carreira's group at ETH as a postdoctoral fellow and explored the field of asymmetric catalysis. In the fall of 2014 David joined the faculty at the University of Illinois, Urbana-Champaign.

研究领域

Organic chemists have the advantage of designing and creating de novo complex molecular architectures. Therefore, central to our research program is the discovery of new reactivities and guiding principles for organic synthesis and their application to solve problems that benefit chemistry and enable advances in the allied fields of chemical biology, material science, and medicine. We are especially attracted to the problems encountered at the frontline of organic synthesis, where established approaches and methods reach their limits and the development of new solutions and approaches is highly desirable and necessary. Natural products provide a powerful setting to examine and study methods as well as to bridge organic synthesis and human medicine. Particular emphasis is placed on identification and analysis of new chemotypes that display promising therapeutic potential and are characterized by novel or unknown activities to disease-related biomolecules. Research interests of the group are the synthesis of structurally complex, biologically active natural products where fresh approaches and methods culminate in innovative design and efficient outcomes. Natural Products Chemistry and Synthesis Synthetic Methods The discovery and development of novel transformations that advance the field is a continuous endeavor and driving force for the discipline. The Sarlah group is intensely involved in the discovery and development of catalytic asymmetric transformations as well as stoichiometric processes. Specifically, the focus is on transformations that fundamentally expand the retrosynthetic arsenal and provide access to high value-added compounds. Chemical Biology and Medicinal Chemistry Synthetic efforts related to secondary metabolites provide material for detailed biological mode-of-action studies and opportunities to assess the set of minimal structural elements that define the pharmacophore. We seek to explore biomolecular mechanisms of action and design simplified, nature-inspired, functional building blocks for discovery chemists in medicinal endeavors and material science.

近期论文

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Total Synthesis of Lycoricidine and Narciclasine by Chemical Dearomatization of Bromobenzene E. H. Southgate, D. Holycross, D. Sarlah Angew. Chem. Int. Ed. 2017, early view, DOI: 10.1002/anie.201709712. Arenophile-Mediated Dearomative Reduction Mikiko Okumura, Stephanie M. Nakamata Huynh, Jola Pospech, D. Sarlah Angew. Chem. Int. Ed. 2016, 55, 15910–15914. Dearomative Dihydroxylation with Arenophiles E. H. Southgate, J. Pospech, J. Fu, D. R. Holycross, D. Sarlah Nature Chem. 2016, 8, 922–928. Enantioselective Polyene Cyclizations C. N. Ungarean, E. H. Southgate, D. Sarlah Org. Biomol. Chem. 2016, 14, 5454–5467.