研究领域

Single-molecule and ensemble studies of protein synthesis

We are interested in the mechanisms of the ribosome function. The ribosome is a central component of cell metabolism, translating genetic code and synthesizing proteins in all living organism. The ribosome is an extremely complex and highly dynamic machine. Our research is focused on the mechanics of ribosome movement along mRNA during protein synthesis. Movement of ribosomes along mRNA is essential attribute of protein synthesis in all organisms and often used to regulate protein expression.

近期论文

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2015 Jan 30 Salsi E, Farah E, Netter Z, Dann J, Ermolenko DN. "Movement of Elongation Factor G between Compact and Extended Conformations." Journal of molecular biology. 2015 Jan 30; 427(2):454-67. Epub 2014 Nov 15. 2014 Oct 21 Salsi E, Farah E, Dann J, Ermolenko DN. "Following movement of domain IV of elongation factor G during ribosomal translocation." Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct 21; 111(42):15060-5. Epub 2014 Oct 06. 2014 Sep 1 Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE. "A post-translational regulatory switch on UPF1 controls targeted mRNA degradation." Genes & development. 2014 Sep 1; 28(17):1900-16. 2013 Oct 22 Azpurua J, Ke Z, Chen IX, Zhang Q, Ermolenko DN, Zhang ZD, Gorbunova V, Seluanov A. "Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage." Proceedings of the National Academy of Sciences of the United States of America. 2013 Oct 22; 110(43):17350-5. Epub 2013 Sep 30. 2013 Jul 23 Svidritskiy E, Ling C, Ermolenko DN, Korostelev AA. "Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome." Proceedings of the National Academy of Sciences of the United States of America. 2013 Jul 23; 110(30):12283-8. Epub 2013 Jul 03.