王广成 - 吉首大学 - 化学化工学院

研究领域

应用化学，目前主要研究方向是：活性天然产物的结构修饰与创新药物研究、小分子药物设计与合成工艺研究。

近期论文

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[1] G. Wang, F. Wang, D. Cao, Y. Liu, R. Zhang, H. Ye, X. Li, L. He, Z. Yang, L. Ma, A. Peng, M. Xiang, Y. Wei, L. Chen. Synthesis, structure–activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. Bioorganic & Medicinal Chemistry Letters, 2014, 24(14): 3158-3163. [2] G. Wang, C. Li, L. He, K. Lei, F. Wang, Y. Pu, Z. Yang, D. Cao, L. Ma, J. Chen, Y. Sang, X. Liang, M. Xiang, A. Peng, Y. Wei, L. Chen. Design, Synthesis and Biological Evaluation of a Series of Pyrano Chalcone Derivatives Containing Indole Moiety as Novel Anti-tubulin Agents. Bioorganic & Medicinal Chemistry, 2014, 22(7): 2060–2079. [3] G. Wang, F. Peng, D. Cao, Z. Yang, X. Han, J. Liu, W. Wu, L. He, L. Ma, J. Chen, Y. Sang, M. Xiang, A. Peng, Y. Wei, L. Chen. Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry, 2013, 21(21): 6844-6854. [4] G. Wang, W. Wu, F. Peng, D. Cao, Z. Yang, L. Ma, N. Qiu, H. Ye, X. Han, J. Chen, J. Qiu, Y. Sang, X. Liang, Y. Ran, A. Peng, Y. Wei, L. Chen. Design, synthesis, and structure–activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. European journal of medicinal chemistry, 2012, 54:793-803. [5] G. Wang, C. Deng, C. Xie, L. Ma, J. Yang, N. Qiu, Q. Xu, T. Chen, F. Peng, J. Chen, J. Qiu, A. Peng, Y. Wei, L. Chen. Synthesis and biological evaluation of novel dimethyl[1,1’-biphenyl]-2,2’-dicarboxylate derivatives containing thiazolidine-2,4- dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. European Journal of Medicinal Chemistry, 2011, 46(12): 5941-5948. [6] G. Wang, B. Qi, H. Zheng, Z. Chen, X. Wei, L. Ma, Y. Ma, Y. Wei, Y. Luo, L. Chen. (Z)-5-(4-Methoxybenzylidene) thiazolidine-2, 4-dione, a Novel Readily Available and Orally Active Glitazone, Attenuates the Bleomycin-Induced Pulmonary Fibrosis in Vivo. Biological and Pharmaceutical Bulletin, 2011, 34(2): 219-225. [7] F. Peng, G. Wang, X. Li, D. Cao, Z. Yang, L. Ma, H. Ye, X. Liang, Y. Ran, J. Chen, J. Qiu, C. Xie, C. Deng, M. Xiang, A. Peng, Y. Wei, L. Chen. Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents. European journal of medicinal chemistry, 2012, 54: 272-280. [8] G. Wang, Y. Yang. (E)-1-(5-Hy-droxy-2,2-dimethyl-2H-chromen-6-yl)-3-(3,4,5- trimeth-oxy-phen-yl)prop-2-en-1-one. Acta crystallographica. Section E, Structure reports online, 2011, 67(5): o1265.