Weix, Daniel J. - University of Rochester

个人简介

Ph.D. 2005, University of California, Berkeley, CA B.A. 2000, Columbia University, New York, NY

研究领域

Our research program is focused on the development of conceptually new catalytic methods for organic synthesis. Our goals are to uncover, study, and design new catalytic cycles as well as develop reactions of practical value. We achieve these goals through a mixture of organometallic mechanistic studies, organic reaction development, and collaborations. Our researchers come from both synthetic organic and inorganic backgrounds and all students can expect to be well versed in current organic methods and organometallic mechanisms. At present, we are particularly inspired by the diverse reactivity of first-row transition metals (Mn, Fe, Co, Ni, Cu), the untapped potential of combining organic radicals with transition metals, multimetallic catalysis, and the challenge of cross-coupling two different electrophiles selectively. A variety of cross-electrophile coupling reactions that have been developed in the Weix group are summarized in Figure 1. A particular strength of cross-electrophile coupling is functional group compatibility, even with mild carbon nucleophiles.

近期论文

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Caputo, Jill A.; Frenette, Leah C.; Zhao, Norman; Sowers, Kelly L.; Krauss, Todd D.; Weix, Daniel J. "General and Efficient C–C Bond Forming Photoredox Catalysis with Semiconductor Quantum Dots," J. Am. Chem. Soc. 2017, ASAP, . DOI: 10.1021/jacs.6b13379 Huihui, Kierra M. M.; Shrestha, Ruja; Weix, Daniel J. "Nickel-Catalyzed Reductive Conjugate Addition of Primary Alkyl Bromides to Enones To Form Silyl Enol Ethers," Org. Lett. 2017, 19, 340-343. DOI: 10.1021/acs.orglett.6b03509 Huang, Liangbin; Weix, Daniel J. "Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides," Org. Lett. 2016, 18, 5432-5435. DOI: 10.1021/acs.orglett.6b02862 Hansen, Eric C.*, Pedro, Dylan J.; Wotal, Alexander C.; Gower, Nicholas J.; Nelson, Jade D.; Caron, Stephane; Weix, Daniel J.* "New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries," Nat. Chem. 2016, 8, 1126-1130. DOI: 10.1038/NCHEM.2587 Anka-Lufford, Lukiana L.; Huihui, Kierra M. M.; Gower, Nicholas J.; Ackerman, Laura K. G.; Weix, Daniel J. "Nickel-Catalyzed Cross-Electrophile Coupling with Organic Reductants in Non-Amide Solvents," Chem.–Eur. J. 2016, 22, 11564-11567. DOI: 10.1002/chem.201602668 Huihui, Kierra M. M.; Caputo, Jill A.; Melchor, Zulema; Olivares, Astrid M.; Spiewak, Amanda M.; Johnson, Keywan A.; DiBenedetto, Tarah A.; Kim, Seoyoung; Ackerman, Laura K. G.; Weix, Daniel J. "Decarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide Esters with Aryl IodidesDecarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide Esters with Aryl Iodides," J. Am. Chem. Soc. 2016, 138, 5016–5019. DOI: 10.1021/jacs.6b01533 Johnson, Keywan A.; Biswas, Soumik; Weix, Daniel J. "Cross-Electrophile Coupling of Vinyl Halides with Alkyl Halides," Chem.–Eur. J. 2016, 22, 7399-7402. DOI: 10.1002/chem.201601320 Wotal, Alexander C.; Batesky, Donald C.; Weix, Daniel J.; Zhang, Yongda; Senanayake, Chris H. "Nickel-Catalyzed Synthesis of Ketones from Alkyl Halides and Acid Chlorides: Preparation of Ethyl 4-Oxododecanoate," Org. Synth. 2016, 93, 50-62. DOI: 10.15227/orgsyn.093.0050 Chen, Chi; Hecht, Maxwell B.; Kavara, Aydin; Brennessel, William W.; Mercado, Brandon Q.; Weix, Daniel J.; Holland, Patrick L. "Rapid, Regioconvergent, Solvent-Free Alkene Hydrosilylation with a Cobalt Catalyst," J. Am. Chem. Soc. 2015, 137, 13244–13247. DOI: 10.1021/jacs.5b08611 Ackerman, Laura K. G.; Lovell, Matthew M.; Weix, Daniel J. "Multimetallic catalysed cross-coupling of aryl bromides with aryl triflates," Nature 2015, 524, 454-457. DOI: 10.1038/nature14676 Weix, Daniel J. "Methods and Mechanisms for Cross-Electrophile Coupling of Csp2 Halides with Alkyl Electrophiles," Acc. Chem. Res. 2015, 48, 1767-1775. DOI: 10.1021/acs.accounts.5b00057 Dorn, Stephanie C. M.; Olsen, Andrew K.; Kelemen, Rachel, E.; Shrestha, Ruja; Weix, Daniel J. "Nickel-catalyzed reductive arylation of activated alkynes with aryl iodides," Tetrahedron Lett. 2015, 56, 3365-3367. DOI: 10.1016/j.tetlet.2015.02.120 Zhao, Yang; Weix, Daniel J. "Enantioselective Cross-Coupling of meso-Epoxides with Aryl Halides," J. Am. Chem. Soc. 2015, 137, 3237–3240. DOI: 10.1021/jacs.5b01909 Caputo, Jill A.; Naodovic, Marina; Weix, Daniel J. "Nickel-Catalyzed Allylation of α-Amido Sulfones To Form Protected Homoallylic Amines," Synlett. 2015, 26, 323-326. DOI: 10.1055/s-0034-1379539 Ackerman, Laura K. G.; Anka-Lufford, Lukiana L.; Naodovic, Marina; Weix, Daniel J. "Cobalt co-catalysis for cross-electrophile coupling: diarylmethanes from benzyl mesylates and aryl halides," Chem. Sci. 2015, 6, 1115-1119. DOI: 10.1039/C4SC03106G