个人简介
落继先:女,硕士生导师,山西朔州人;
教育背景
2005.9-2010.7东北师范大学生命科学学院遗传与细胞研究所硕博连读
2000.9-2004.7长春师范学院生命科学学院学士
研究背景
2014.1-至今山西大学生命科学学院副教授
2012.11-2014.3德州大学医学分部(UniversityofTexasMedicalBranch)访问学者
2011.11-2015.2山西大学生物学博士后
2010.7-2013.12山西大学生命科学学院讲师
研究领域
研究方向:肺癌和白血病的转移、浸润机制研究与药物研发
主持的科研项目
[1]RhoGDI2的磷酸化在SDF-1引起的β1整合素介导的Jurkat细胞迁移过程中的作用研究,国家自然科学青年基金(31401216),25万;镉影响华溪蟹蜕皮过程的分子机制,国家基金委博士后基金面上基金(2012M510773),5万;
[2]RhoGDI2在PSGL-1信号通路中的作用及机制研究,教育部新教师基金(20121401120006),4万;
[3]SDF-1在白血病细胞浸润中的作用机制研究,山西省回国留学人员科研资助项目(2017-012),2万;
[4]Rho在T细胞急性白血病中的作用机制研究和其在白血病靶向治疗中的应用,山西省自然科学基金面上项目(201901D111010),5万;
参与的科研项目
[1]糖尿病人肿瘤易感性增高的生物学原理和分子机制以及肿瘤预防方法的研究,山西省自然科学基金面上项目(201601D011066),3万,排名第二;
[2]2015细胞中心体扩增的分子机制的研究,山西省国际科技合作计划项目(2015081034),10万,排名第三;
[3]重组华溪蟹金属硫蛋白在AUMO融合系统中的表达及其功能研究(高等学校博士学科点专项科研基金博导类(20111401110010),6万,排名第三;
[4]PI3K激酶在L-选择素和PSGL-1介导的白细胞起始黏附过程中的信号转导作用研究,国家自然科学基金面上基金(30971498),35万,排名第三。
近期论文
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[1]JixianLuo,DanWei,DingyunLi,LanWang.Nitricoxidefunctionsinstromalcell-derivedfactor-1-inducedcytoskeletonchangesandthemigrationofJurkatcells.OncologyLetters.16(5):6685-6690.2018.
[2]JixianLuo.PI3KisalinkerbetweenL-selectinandPSGL-1SignalingtoIL-18transcriptionalactivationatthepromoterlevel.Inflammation.41(2):555-561.2018.
[3]JixianLuo,DingyunLi,DanWei,XiaoguangWang,LanWang,XianluZeng.RhoAandRhoCareinvolvedinstromalcell-derivedfactor-1-inducedcellmigrationbyregulatingF-actinredistributionandassembly.MolecularandCellularBiochemistry.436(1-2):13-21.2017.
[4]JixianLuo,KoaHosoki,AttilaBacsi,ZsoltRadak,MuralidharL.Hegde,SanjivSur,TapasK.Hazra,AllanR.Brasier,XueqingBa,IstvanBoldogh.8-OxoguanineDNAglycosylase-1-mediatedDNArepairisassociatedwithRhoGTPaseactivationandα-smoothmuscleactinpolymerization.FreeRadicalBiology&Medicine.73:430-8.2014.
[5]JixianLuo,SihuiPei,WeixinJing,EnminZou,LanWang.CadmiuminhibitsmoltingofthefreshwatercrabSinopotamonhenanensebyreducingthehemolymphecdysteroidcontentandtheactivitiesofchitinaseandN-acetyl-β-glucosaminidaseintheepidermis.Comparativebiochemistryandphysiology.PartC.169:1-6.2014.
[6]JixianLuo,TingshuangXu,ChunfengLi,XueqingBa,XiaoguangWang,YongJiang,XianluZeng.p85-RhoGDI2,anovelcomplex,isrequiredforPSGL-1-inducedβ1integrin-mediatedlymphocyteadhesiontoVCAM-1.TheInternationalJournalofBiochemistry&CellBiology.45(12):2764-2773.2013.
[7]JixianLuo,ChunfengLi,TingshuangXu,WenaiLiu,XueqingBa,XiaoguangWang,XianluZeng.PI3Kisinvolvedinβ1integrinclusteringbyPSGL-1andpromotesβ1integrin-mediatedJurkatcelladhesiontofibronectin.MolecularandCellularBiochemistry.385(1-2):287-295.2013.
[8]JixianLuo,TingshuangXu,XiaoguangWang,XueFeng,XueqingBa,XianluZeng.PI3KisinvolvedinL-selectin-andPSGL-1-mediatedneutrophilrollingonE-selectinviaF-actinredistributionandassembly.JournalofCellular.Biochemistry.110(4):910-919.2010.
参与发表的SCI论文
[1]YongquanLi,HuizhenYang,NaLiu,JixianLuo,QianWang,LanWang.Cadmiumaccumulationandmetallothioneinbiosynthesisincadmium-treatedfreshwatermusselAnodontawoodiana.PLoSOne.10(2):e0117037.2015.
[2]XueqingBa,AttilaBacsi,JixianLuo,LeopoldoAguilera-Aguirre,XianluZeng,ZsoltRadak,AllanR.Brasier,IstvanBoldogh.8-oxoguanineDNAglycosylase-1augmentsproinflammatorygeneexpressionbyfacilitatingtherecruitmentofsite-specifictranscriptionfactors.JournalofImmunology.192(5):2384-94.2014.
[3]TingshuangXu,WenaiLiu,JixianLuo,ChunfengLi,XueqingBa,KhamalKwesiAmpah,XiaoguangWang,YongJiang,XianluZeng.LipidRaftisrequiredforPSGL-1ligationinducedHL-60celladhesiononICAM-1.PLoSOne.8(12):e81807.2013.
[4]WenwenLei,LanWang,DongmeiLiu,TuanXu,JixianLuo.HistopathologicalandbiochemicalalternationsoftheheartinducedbyacutecadmiumexposureinthefreshwatercrabSinopotamonyangtsekiense.Chemosphere.84(5):689-94.2011.
[5]LinglingCui,CuixiaChen,TingXu,JuechaoZhang,XinShang,JixianLuo,LiangChen,XueqingBa,XianluZeng.c-AblKinaseisrequiredforβ-2integrin-medatedneutrophiladhesion.JournalofImmunology.182(5):3233-3242.2009.
[6]TingXu,LiangChen,XinShang,LinglingCui,JixianLuo,CuixiaChen,XueqingBaandXianluZeng.CriticalroleofLckinL-selectinsignalinginducedbysulfatidesengagement.JournalofLeukocyteBiology.84(8):1192-1201.2008.
[7]CuixiaChen,XinShang,LinglingCui,TingXu,JixianLuo,XueqingBa,XianluZeng.L-selectinligation-inducedCSF-1genetranscriptionisregulatedbyAP-1inac-Ablkinase-dependentmanner.HumanImmunology.69(8):501-509.2008.
[8]CuixiaChen,XinShang,TingXu,LinglingCui,JixianLuo,XueqingBa,ShuiHaoandXianluZeng.c-AblisrequiredforthesignalingtransductioninducedbyL-selectinligation.EuropeanJournalofImmunology.37(11):3246-3258.2007.