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个人简介

教育经历 2003.07--2006.01美国俄亥俄州立大学生物学院生物化学系,高级研究员 2003.01--2003.07美国俄亥俄州立大学生物学院生物化学系,博士后研究员 1999.09--2002.07北京大学药学院,药物化学专业,博士 1986.09--1989.07吉林大学理论化学研究所,物理化学专业,硕士 1982.09--1986.07吉林大学化学系,有机化学专业,学士 工作经历 2020.09-至今河南师范大学化学化工学院教授,博士生导师 2018.09-2020.09河南师范大学化学化工学院教授,博士生导师,研究生院院长 2012.07-2018.08河南师范大学化学化工学院教授、院长,省级特聘教授/博士生导师 1999.11-2012.07河南师范大学化学与环境科学学院教授,特聘教授/博士生导师 1994.11-1999.11河南师范大学化学与环境科学学院副教授 1992.07-1994.11河南师范大学化学与环境科学学院讲师 1989.07-1992.07河南师范大学化学与环境科学学院助教 荣誉奖项 2013年国务院特殊津贴专家 2012年全国优秀科技工作者 2011《有机合成化学》河南省双语教学示范精品课程 2009年河南省劳动模范(先进工作者) 2008年河南省优秀专家 2005年河南省学术技术带头人

研究领域

1.含糖药物的新药设计与合成 2.有机合成化学,绿色有机合成 3.药物研发和药物生产新工艺研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Kai Sun, Guofeng Li, Yuyang Li, Jie Yu, Qing Zhao, Zhiguo Zhang, Guisheng Zhang, Oxidative Radical Relay Functionalization for the Synthesis of Benzimidazo[2,1-a]iso-quinolin-6(5H)-ones,Adv. Synth. Catal.,2020,362, 1947-1954. QingfengLiu,Tong-XinLiu,JinliangMa,GuishengZhang,Palladium-Catalyzed Three-Component Tandem Coupling-Carboannulation Reaction Leading to Polysubstituted [60]Fullerene-Fused Cyclopentanes,Org. Lett.,2020,22, 284-289. Weiwei Ma,Jingjing Bi,Chuanfang Zhao,Zhiguo Zhang,Tongxin Liu,GuishengZhang,Synthesis and biological activities of amino acids functionalized alpha-GalCer analogues,Bioorg. Med. Chem.,2020, 28, Guo-Jiang Mao,Zhen-Zhen Liang,Guang-Qi Gao,Ying-Ying Wang, Xin-Yu Guo,Li Su,Hua Zhang,Qiu-Juan Ma,Guisheng Zhang,A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke,Anal Chim. Acta,2019,1092, 117-125. Qingfeng Liu, Tong-Xin Liu, Yifei Ru, Xue Zhu,Guisheng Zhang,Palladium-catalyzed decarboxylative heterocyclizations of [60]fullerene: preparation of novel vinyl-substituted [60]fullerene-fusedtetrahydrofurans/pyrans/quinolines,Chem. Commun.,2019,55, 14498-14501. Nana Ma,Mingyue Lv,Tongxin Liu,Mengxiao Song,Yan Liu,Guisheng Zhang,Second-order nonlinear optical properties of [60]fullerene-fused dihydrocarboline derivates: a theoretical study on switch effect,J. Mater. Chem. C,2019,7, 13052-13058. Guo-Jiang Mao,Guang-Qi Gao,Zhen-Zhen Liang,Ying-Ying Wang,Li Su,Zhuo-Xi Wang,Hua Zhang, Qiu-Juan Ma,Guisheng Zhang,A mitochondria-targetable two-photon fluorescent probe with a far-red to near-infrared emission for sensing hypochlorite in biosystems,Anal Chim. Acta,2019,1081, 184-192. Zhiguo Zhang, Xiang Li,Mengmeng Song,Yameng Wang,Dan Zheng,Guisheng Zhang,Gong Chen,Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation,J. Org. Chem.,2019,84, 12792-12799. Tong-Xin Liu,Juan Wei,Pengling Zhang,Yifei Ru,Jinliang Ma,Xingjie Zhang,Nana Ma, Guisheng Zhang,Copper-Catalyzed N-H/C-H Sequential Relay Oxidative Radical Carboannulation: Construction of Diversely Substituted [60]Fullerene-FusedTetrahydrocyclopenta[b]indoles,Org. Lett.,2019,21, 6461-6465. Anlian Zhu,Xiaofang Xing,Shilei Wang,Donghe Yuan,Gongming Zhu, Mingwei Geng,Yuanyang Guo,Guisheng Zhang,Lingjun Li,Multi-component syntheses of diverse 5-fluoroalkyl-1,2,3-triazoles facilitated by air oxidation and copper catalysis,Green Chem.,2019,21, 3407-3412. Qingfeng Liu,Tong-Xin Liu,Nana Ma,Chenhao Tu,Ruoya Wang,Guisheng Zhang,Cu(II)/Mn(III)-Promoted Synergistic Radical N-Heteroannulation Reaction: Synthesis of [60]Fullerene-Fused Tetrahydroquinoline Derivatives,J. Org. Chem.,2019,84, 7255-7264. Zhiguo Zhang,Songnan Wang,Yong Zhang,Guisheng Zhang,Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors,J. Org. Chem.,2019,84, 3919-3926. Xiaopeng Zhang, Zhengwei Li, Qianqian Ding,Xiaochuan Li,Xuesen Fan, Guisheng Zhang,Alkylamino-Directed One-Pot Reaction of N-Alkyl Anilines with CO, Amines and Aldehydes Leading to 2,3-Dihydroquinazolin-4(1H)-ones,Adv. Synth. Catal.,2019,361, 976-982. Guo-Jiang Mao,Zhen-Zhen Liang,Jingjing Bi,Hua Zhang,Hong-Min Meng,Li Su,Yi-Jun Gong,Suling Feng,Guisheng Zhang,A near-infrared fluorescent probe based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatoryresponse,Anal Chim. Acta,2019,1048, 143-153. Yameng Wan,Zhiguo Zhang,Nana Ma,Jingjing Bi,Guisheng Zhang,Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation,J. Org. Chem.,2019,84, 780-791. Tong-Xin Liu,Shuaishuai Yue,Changgeng Wei,Nana Ma,Pengling Zhang,Qingfeng Liu,Guisheng Zhang,Solvent-promoted catalyst-free regioselective N-incorporation multicomponent domino reaction: rapid assembly of -functionalized [60]fullerene-fuseddihydrocarbolines, Chem. Commun.2018,54, 13331-13334. Lei Shi, Jingjing Xu, Jingjing Bi, Zhiguo Zhang, Tongxin Liu, Xiaolan Yang, Guisheng Zhang,Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine Compounds,Chinese J. Org. Chem.,2018,38, 3016-3025. Nana Ma,Changgeng Wei,Shujun Li,Guisheng Zhang,Theoretical insight on ethylene polymerization catalyzed by carborane-containing metal complexes: the role of carborane,Dalton T.,2018,47, 14421-14425. Lingjun Li,Shenlong Huang,Tongpeng Shang,Bo Zhang,Yuanyang Guo,Gongming Zhu,Demin Zhou,Guisheng Zhang,Anlian Zhu,Lihe Zhang,Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands,J. Org. Chem.,2018,83, 13166-13177. Hao Wu,Zhiguo Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu, Guisheng Zhang,Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions,J. Org. Chem.,2018,83, 12880-12886. Zhiguo Zhang,Xiaolong Gao,Haifeng Yu,Guisheng ZhangJianming Liu,Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides,Adv. Synth. Catal.,2018,360, 3406-3411. Beibei Hu,Tong-Xin Liu,Pengling Zhang,Qingfeng Liu,Jingjing Bi,Lei Shi,Zhiguo Zhang,Guisheng Zhang,N-Heterocyclic Carbene-Catalyzed alpha,beta-Unsaturated Aldehydes Umpolung in Fullerene Chemistry: Construction of [60]Fullerene-FusedCyclopentan-1-ones and Cyclohex-2-en-1-ones,Org. Lett.2018,20, 4801-4805. Ning Lu,Zhiguo Zhang,Nana Ma,Conghui Wu,Guisheng Zhang, QngfengLiu,Tongxin Liu,Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-alpha-lodomethyl Vinylsulfones,Org. Lett.2018,20, 4318-4322. Hao Wu,Zhiguo Zhang,Qingfeng Liu,Tongxin Liu,Nana Ma, Guisheng Zhang,Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from o-Aminoacetophenones and Arylboronic Acids,Org. Lett.2018,20, 2897-2901. Nana Ma,Jinjin Gong,Jie Zhang,Shangning Han,Mengxiao Song,Guisheng Zhang,Theoretical Exploration of the Layered Sandwich Cobaltacarborane as a Multi-State NLO Molecular Switch Triggered by Redox,J. Phys. Chem. C,2018,122, 6818-6825. Zhiguo Zhang,Dan Zheng,Yameng Wan,Guisheng Zhang,Jingjing Bi,Qingfeng Liu,Tongxin Liu, Lei Shi,Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides,J. Org. Chem.2018,83, 1369-1376. Shilu Xia,Tong-Xin Liu,Pengling Zhang,Jinliang Ma,Qingfeng Liu,Nana Ma,Zhiguo Zhang,Guisheng Zhang,Broad Synthesis of Disubstituted Dihydrofuran-Fused [60]Fullerene Derivatives via Cu(I)/Ag(I)-Mediated Synergistic Annulation Reaction,J. Org. Chem.2018,83, 862-870. Tong-Xin Liu,Shaoshuai Hua,Nana Ma,Pengling Zhang,Jingjing Bi,Zhiguo Zhang,Guisheng Zhang,Reactivity and Synthetic Applications of alpha-Functionalized Oxime Acetates: Divergent Access to Fulleropyrrolidines and Mono- and Disubstituted 1-Fulleropyrrolines via Copper-Catalyzed Redox-Neutral N-Heteroannulation with [60]Fullerene,Adv. Synth. Catal.,2018,360, 142-152.

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