个人简介

B.S. University of Guelph, (Canada) 1983 Ph.D. University of Guelph, (Canada) 1988 Canadian Medical Research Council Fellow, Mayo Clinic, 1991

研究领域

Biological/bioanalytical and clinical chemistry

Our research group has developed a technique for fabricating microfluidic devices with complex multilayer architectures using a laser printer, a CO2 laser cutter, an office laminator, and common overhead transparencies as a printable substrate via a laser print/cut and laminate (PCL) methodology. The printer toner serves three functions; (1) it defines the microfluidic architecture, (2) acts as the bonding agent and, (3) provides printable, hydrophobic ‘valves’ for fluidic flow control. Using common graphics software, the protocol produces microfluidic devices with a design-to-device time of ~40 min. Devices of any shape can be generated for an array of multistep assays with colorimetric detection of molecular species ranging from small molecules to proteins. The simplicity of the protocol, availability of the equipment and substrate and cost-effective nature of the process make microfluidic devices available to those who might benefit most from expedited, microscale chemistry.

近期论文

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Simultaneous metering and dispensing of multiple reagents on passivelycontrolled microdevice solely by finger pressing. Xu K, Begley M, Landers JP. Lab on a Chip. 15: 867-876 (2015). Integrated sample-in-answer-out microfluidic chip for Rapid HumanIdentification by STR analysis. Le Roux D, Root B, Reedy C, Hickey J, Scott O, Bienvenue J, Landers JP, Chassagne L, Mazancourt P. Lab on a Chip. 14:4415-4425 (2014). DNA Analysis Using an Integrated Microchip for Multiplex PCRAmplification and Electrophoresis for Reference Samples. Le Roux D, Root B, Reedy C, Hickey J, Scott O, Bienvenue J, Landers JP, Chassagne L, Mazancourt P. Analytical Chemistry. 86:8192-8199 (2014). Rapid, cost-effective DNA quantification via a visually-detectableaggregation of superparamagnetic silica-magnetite nanoparticles. Liu Q, Li J, Liu H, Tora I, Ide M, Lu J, Davis R, Green D, Landers JP. Nano Research. 7:755-764 (2014). Dual-force aggregation of magnetic particles enhances label-freequantification of DNA at the sub-single cell level. Nelson D, Strachan B, Sloane H, Li J, Landers JP. Analytica Chimica Acta. 819:34-41 (2014). Enhanced recovery of spermatozoa and comprehensive lysis of epithelialcells from sexual assault samples having a low cell counts or aged up to one year. Loundsbury J, Nambia S, Karlsson A, Cunniffe H, Norris J, Ferrance J, Landers JP. Forensic Science International: Genetics. 8:84-89 (2014).