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个人简介

B.A. Kalamazoo College, 1984 M.T.S. Harvard Divinity School, 1988 Ph.D. The University of Chicago, 1993 N.I.H. Postdoctoral Fellow, California Institute of Technology, 1993-1995

研究领域

Polymeric metal complexes/biomaterials/multifunctional nanoscale assemblies

Polymeric Metal Complexes. Metallobiomaterials for Medicine and Biotechnology. Bio-inspired and Sustainable Design. Responsive Nanoscale Assemblies. Research in the Fraser Lab is concerned with the synthesis, properties and applications of metal complexes with polymeric ligands. Like metalloproteins, polymeric metal complexes feature site-isolated metal centers in well-defined macromolecular environments. These multifunctional targets are prepared via combination of coordination chemistry with living polymerization methodologies and offer many opportunities for further modification. The development of new synthetic methodologies involving main group, transition metal and lanthanide complexes with bipyridine and diketonate macroligands has paved the way for the discovery of some fascinating and unexpected properties and reactivity. The resulting hybrid materials can function as soluble agents, films, nanoparticles, or bulk materials, and block copolymers can form higher order nanoscale assemblies. Presently, we are exploring uses for these metallobiomaterials as optical imaging agents, oxygen sensors, drug delivery systems, and responsive materials in biomedicine and sustainable design.

近期论文

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Aromatic difluoroboron β-diketonate complexes: effects of π-conjugation and media on optical properties. Xu S, Evans RE, Liu T, Zhang G, Demas JN, Trindle CO, Fraser CL. Inorg Chem. 52:3597-610 (2013). Laser phosphoroscope and applications to room-temperature phosphorescence. Payne SJ, Zhang G, Demas JN, Fraser CL, Degraff BA. Appl Spectrosc. 65:1321-4 (2011). An easy method to monitor lactide polymerization with a boron fluorescent probe. Zhang G, Xu S, Zestos AG, Evans RE, Lu J, Fraser CL. ACS Appl Mater Interfaces. 2, 3069-74 (2010). Stereocomplexed Poly(lactic acid)-Poly(ethylene glycol) Nanoparticles with Dual-Emissive Boron Dyes for Tumor Accumulation. Kersey FR, Zhang G, Palmer GM, Dewhirst MW, Fraser CL. ACS Nano. 4:4989- 4996(2010). Zhang G, Lu J, Fraser CL. Inorg Chem. in press (2010).

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