个人简介

Ph.D., University of California at Berkeley

研究领域

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Bioanalytical chemistry/single molecule detection and spectroscopy/laser spectroscopy/optical and scanning probe microscopy/optical biosensors for pharmaceutical and clinical chemistry.

Our research contributes to both the fundamental and applied aspects of single molecule spectroscopy. One area of current interest is in studying the spectroscopic properties of individual fluorescent dye molecules that have been used to label specific sites of biological macromolecules. These studies provide us with insight into the chemical environment of the dye and allow us to observe subtle differences in these properties from molecule to molecule. By simultaneously recording atomic force microscope images, we can directly probe the relationship between the spectroscopic properties of the dye and the structures of the biomolecules. Another major emphasis of our research is in the development of new analytical instruments that combine the speed and sensitivity of single molecule spectroscopy with the selectivity of electrophoresis. A variety of techniques are used to determine the electrophoretic mobilities of single molecules in microcapillaries or in gel matrices, including fluorescence correlation spectroscopy and single molecule tracking microscopy. Because of their different electrophoretic mobilities, the components of a mixture can be analyzed without the need to perform a chemical separation. More rapid and efficient methods for characterizing the interactions between small molecules, such as drugs or environmental toxins, and biological molecules, like nucleic acids, peptides, and proteins, are being developed in this way