个人简介

Ph.D., University of Toronto

研究领域

Organic and biological chemistry/new synthetic methodology/synthesis of chemically and biologically interesting natural products and study of their molecular mechanisms of action/study of enzymatic reaction mechanisms and development of therapeutic agents.

Our general interest is in the area of synthetic organic chemistry, particularly the development of novel methodologies and their application in the synthesis of natural products exhibiting unique chemical complexity and significant biological activity. One of our recent focuses has been functionalization of olefins with an emphasis on chemo-, regio-, enantio-, and diastereoselectivity. The following scheme highlights some of our group's recent endeavors

近期论文

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Yingguang Zhu, Richard G. Cornwall, Haifeng Du, Baoguo Zhao, & Yian Shi. "Catalytic Diamination of Olefins via N−N Bond Activation", Acc. Chem. Res. 2014, 47, 3665−3678. Yingguang Zhu, Tao Xiong, Wenyong Han, & Yian Shi. "Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone", Org. Lett. 2014, 16, 6144−6147. Yingguang Zhu & Yian Shi. "Cu(I)-Catalyzed Sequential Diamination and Dehydrogenation of Terminal Olefins: A Facile Approach to Imidazolinones", Chem. Eur. J. 2014, 20, 13901–13904. Huaiji Zheng, Yingguang Zhu, & Yian Shi. "Palladium(0)-Catalyzed Heck Reaction/CH Activation/Amination Sequence with Diaziridinone: A Facile Approach to Indolines", Angew. Chem. Int. Ed. 2014, 53, 11280–11284. Yingguang Zhu, Qian Wang, Richard G. Cornwall, & Yian Shi. "Organocatalytic Asymmetric Epoxidation and Aziridination of Olefins and Their Synthetic Applications", Chem. Rev. 2014, 114, 8199−8256. Yingguang Zhu & Yian Shi. "A Facile Copper(I)-Catalyzed Homocoupling of Terminal Alkynes to 1,3-Diynes with Diaziridinone under Mild Conditions", Org. Biomol. Chem. 2013, 11, 7451-7454. Thomas A. Ramirez, Qian Wang, Yingguang Zhu, Huaiji Zheng, Xingao Peng, Richard G. Cornwall, & Yian Shi. "Pd(0)-Catalyzed Sequential C-N Bond Formation via Allylic and Aromatic C-H Amination of α-Methylstyrenes with Diaziridinone", Org. Lett. 2013, 15, 4210-4213. Yingguang Zhu & Yian Shi. "Facile Cu(I)-Catalyzed Oxidative Coupling of Anilines to Azo Compounds and Hydrazines with Diaziridinone under Mild Conditions", Org. Lett. 2013, 15, 1942-1945. Yingguang Zhu, Baoguo Zhao, & Yian Shi. "Highly Efficient Cu(I)-Catalyzed Oxidation of Alcohols to Ketones and Aldehydes with Diaziridinone", Org. Lett. 2013, 15, 992-995. Richard G. Cornwall, Baoguo Zhao, & Yian Shi. "Catalytic Asymmetric Synthesis of Cyclic Sulfamides from Conjugated Dienes", Org. Lett. 2013, 15, 796-799. O. Andrea Wong, Brian Nettles, &Yian Shi. "Oxidations", Carbohydrates – Tools for Stereoselective Synthesis, Boysen, M.M.K. Ed., WILEY-VCH, Germany, 2013, pp 321-350. Richard G. Cornwall, O. Andrea Wang, Haifeng Du, Thomas A. Ramirez, & Yian Shi. "A Novel Class of Tunable Cyclopropanation Reagents (RXZnCH2Y) and Their Synthetic Applications", Org. Biomol. Chem. 2012, 10, 5498-5513. Thomas A Ramirez, O. Andrea Wang, & Yian Shi. "Discussion Addendum for: Synthesis of 1,2:4,5-Di-o-isopropylidene–D-erythro-2,3-hexodiulo-2,6-pyranose. A Highly Enantioselective Ketone Catalyst for Epoxidation/Asymmetric Epoxidation of trans-β-Methylstyrene and 1-Phenylcyclohexene using a D-Fructose-derived Ketone: (R,R)-trans-β–Methylstyrene Oxide and (R,R)-1-Phenylcyclohexene Oxide", Org. Synth. 2012, 89, 350-373. O. Andrea Wong, Thomas A. Ramirez, &Yian Shi. "Organocatalyzed Asymmetric Epoxidation of Alkenes", Comprehensive Chirality, Carreira, E. M. and Yamamoto, H. Ed., Elsevier Ltd., 2012, Vol. 6, pp 528-553. Click here to see article. Thomas A Ramirez & Yian Shi. "Spiro[6H-1,3-dioxolo[4,5-c]pyran-6,5’-oxazolidine]-3’-carboxylic acid, tetrahydro-2,2-dimethyl-2’,7-dioxo-,2-methyl-2-propyl ester, (3aR, 5’S, 7aR)-", Electronic Encyclopedia of Reagents for Organic Synthesis, 2012. O. Andrea Wang, Thomas A. Ramirez, & Yian Shi. "Asymmetric Ketone and Iminium Salt-Catalyzed Epoxidations", Science of Synthesis, List, B. Ed., Georg Thieme Verlag KG, Stuttgart, Germany, 2012, pp 783-830.