Oldfield, Eric - University of Illinois at Urbana-Champaign

个人简介

Professor Eric Oldfield was educated in London, Bristol and Sheffield, then moved to the US as a European Molecular Biology Organization Fellow at Indiana University with Adam Allerhand and a Visiting Scientist at MIT with John Waugh.

近期论文

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E. Oldfield. Targeting Isoprenoid Biosynthesis for Drug Discovery: Bench to Bedside. Accts. Chem. Res. (2010) W. Wang, J. Lia, K. Wang, C. Huang, Y. Zhang, E. Oldfield.Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG). PNAS, 107, 11189-11193, (2010). A.P. Singh, Y. Zhang, J.H. No, R.Docampo, V.Nussenzweig, E. Oldfield. Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth Antimicrob. Agents & Chemoth., 54, 2987-2993, (2010). K. Wang, Y. Zhang, J.H. No, R. Docampo, V. Nussenzweig, E. Oldfield. Inhibition of the Fe4S4-Cluster-Containing Protein IspH (LytB): Electron Paramagnetic Resonance, Metallacycles, and Mechanisms. JACS, 132,6719-6727 (2010). W. Wang, K. Wang, Y.L. Liu, J.H. No, J. Li, M.J. Nilges, E. Oldfield. Bioorganometallic mechanism of action, and inhibition, of IspH. PNAS. 107, 4522-4527, (2010). S. Mukherjee, C. Huang, F. Guerra, K. Wang, E. Oldfield. Thermodynamics of Bisphosphonates Binding to Human Bone: A Two-Site Model. JACS, 131, 8375-76, (2009) C.H. Huang, S.B. Gabelli, E. Oldfield, L.M. Amzel. Bind of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl disphosphate synthase homodimer. Proteins, 78, 888-899, (2010). R. Cao, Y. Zhang, F.M. Mann, C. Huang, D. Mukkamala, M.P. Hudock, M.E. Mead, S. Prisic, K. Wang, F.Y. Lin, T.K. Chang, R.J. Peters, E. Oldfield. Diterpene cyclases and the nature of the isoprene fold. Proteins, 78, 2417-2432, (2010). Y. Zhang, R. Cao, F. Yin, F.Y. Lin, H. Wang, K. Krysiak, D. Mukkamala, K. Houlihan, J. Li, C.T. Morita, E. Oldfield.Liphilic pyridinium bisphosphonates: Potent gamma-delta T cell stimulators.Angew. Chem. Int. Ed., 49, 1136-1138, (2010). Y. Song, C.I. Liu, F.Y. Lin, J.H. No, M. Hensler, Y.L. Liu, W.Y. Jeng, J. Low, G.Y. Liu, V. Nizet, A.H.J. Wang, E. Oldfield. Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus: In Vitro, in Vivo, and Crystallographic Results.J. Med. Chem., 52, 3869-3880, (2009). Y.Zhang, R. Cao, F. Yin, M.P. Hudock, R.T. Guo, K. Krysiak, S. Mukherjee, Y.G. Gao, H. Robinson, Y. Song, J.H. No, K. Bergan, A. Leon, L. Cass, A. Goddard, T.K. Chang, F.Y. Lin, E.V. Beek, S. Papapoulos, A.H. Wang, T. Kubo, M. Ochi, D. Mukkamala, E. Oldfield. Lipophillic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation. JACS, 131, 5153-5162, (2009). B. J. Wylie, C. D. Schwieters, E. Oldfield, C. M. Rienstra. Protein Structure Refinement Using 13C# Chemical Shift Tensors. JACS, online I. Rekittke, J. Wiesner, R. Rohrich, U. Demmer, E. Warkentin, W. Xu, K. Troschke, M. Hintz, J. H. No, E. C. Duin, E. Oldfield, H. Jomaa, U. Ermler. Structure of (E)-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway. D. Mukkamala, J. H. No, L. M. Cass, T. K. Chang, E. Oldfield. Bisphosphonate Inhibition of a Plasmodium Farnesyl Diphosphate Synthase and a General Method for Predicting Cell-Based Activity from Enzyme Data. J. Med. Chem., 51, 7827-7833, (2008). G. Sarikonda, H. Wang, K. J. Puan, X. h. Liu, H. K. Lee, Y. Song, M. D. Distefano, E. Oldfield, G. D. Prestwich, C. T. Morita. Photoaffinity Antigens for Human gammadelta T Cells. J. Immunol., 171, 7738-7750, (2008). C. K-M Chen, M.P. Hudock, Y. Zhang, R.T. Guo, R. Cao, J.H. No, P.H. Liang, T.P. Ko, T.H. Chang, S.C. Chang, Y. Song, J. Axelson, A. Kumar, A.H. Wang, E. Oldfield. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem., 51, 5594-607, (2008). Y. Song,J.M. Chan, Z. Tovian, A. Secrest, E. Nagy, K. Krysiak, K. Bergan, M.A. Parniak, E. Oldfield. Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: A QSAR investigation. Bioorg Med Chem., 16, 8959-8967, (2008). P.K. Babu, J.-H. Chung, E. Oldfield, A. Wieckowski CO surface diffusion on platinum fuel cell catalysts by electrochemical NMR Elecrochimica Acta, 53, 6672-6679, (2008). Y. Zhang, E. Oldfield. NMR Hyperfine Shifts in Blue Copper Proteins: A Quantum Chemical Investigation. J. Am. Chem. Soc., 130, 3814-3823, (2008). Cao R, Chen CK, Guo RT, Wang AH, Oldfield E. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins, 73, 431-9, (2008).