姬汴生 - 河南大学 - 天然药物与免疫工程重点实验室

个人简介

教育经历 1980年9月-1985年7月：河南医科大学医学系，获医学学士学位 1987年9月-1990年7月：南京医学院药理学硕士研究生，获医学硕士学位 2002年9月-2005年7月：中国药科大学药理学博士研究生获药理学博士学位工作经历 1990年-1997年：郑州大学基础医学院（原河南医科大学）药理学教研室，助教、讲师 1997年-2002年：郑州大学基础医学院（原河南医科大学）药理学教研室，副教授、硕士生导师 2005年至今：河南大学河南省天然药物与免疫工程重点实验室，任教授、副主任

研究领域

神经元保护、血脑屏障药物通透性调控及逆转肿瘤多药耐药

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Liu L,Huang W,Wang J,Song H,Cen J*,Ji B*.Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.Chem Biol Interact.2017 Jan 25;262:1-11. doi: 10.1016/j.cbi.2016.12.001. Epub 2016 Dec 5. 2.Jianhong Wang, Lu Liu, Juan Cen, Biansheng Ji*BME, a novel compound of anthraquinone, down regulatedP-glycoprotein expression in doxorubicin-resistant human myelogenousleukemia (K562/DOX) cells via generation of reactive oxygen species.Chemico-Biological Interactions 2015,239:139–145 3.Ji Biansheng*,CenJuan,Liu Lu,HeLing.In vitro and in vivo study of dolichyl phosphate on theefflux activity of P-glycoprotein at the blood-brain barrier.Int J Dev Neurosci.2013，31(8)：828-835 4.Gao Y1, Ji BS.N1-(Quinolin-2-ylmethyl) butane-1, 4-diamine, a polyamine analog: inhibition of platelet aggregation mediated by an elevated VASP, and decreased MAPK phosphorylation.Blood Coagul Fibrinolysis. 2014 Jul;25(5):476-85. 5.Ji Bian-Sheng*,Cen Juan，He Ling，Liu Meng，Liu Yan-Qing，Liu Lu.Modulation of P-glycoprotein inrat brain microvessel endothelial cells under oxygen glucose deprivation.Journal of Pharmacy andPharmacology.2013,65(10)：1508-1517 6.Li MS, Cen J, Liu L, He L, Ji BS*. CJY, an isoflavone, interacts with ATPase of P-glycoprotein in the rat brain microvessel endothelial cells (RBMECs). Journal of Chemotherapy.2013，25(6):347-54. 7.Cen J, Liu L, He L, Ji BS*. Interaction of CJY, anisoflavone, with ATPase of P-glycoprotein indoxorubicin-resistanthumanmyelogenousleukemia (K562/DOX) Cells. Drug Res.2013,63(8):429-34 ISSN:0004-4172 8.Cen J, Liu L, Li MS, He L, Wang LJ, Liu YQ, Liu M, Ji BS*. Alteration in P-glycoprotein at the blood–brain barrier in the early period of MCAO in rats. Journal of Pharmacy and Pharmacology.2013,65(5):665–72. ISSN: 2042-7158 9.Cen J, Liu L, He L, Liu M, Wang CJ, Ji BS*. N(1)-(quinolin-2-ylmethyl)butane-1,4-diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia. Int J Dev Neurosci. 2012,Nov; 30(7):584-595. 10.Zhao FQ, Yan L, Cui XH, Lin S, Wang C, Zhang H, Kang XY, Ji BS * Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4. Yao Xue Xue Bao. 2012，May; 47(5):680-684. 11.Bian-Sheng Ji*, Yan-Li Ren and Ling He. The effect of combined CJZ3, a lomerizine derivative, with verapamil on P-glycoprotein efflux function in vitro. Drug Dev Res. 2011, 72(4): 305–309 12.Ling Xu, Meng-Xue Ji, Na Zhao and Bian-Sheng Ji*. 3-butyl-6-fluoro-1 (3H)-isobenzofuranone, a derivative of dl-n-butylphthalide, attenuates hydrogen peroxide-induced damage in PC12 cells. Drug Dev Res. 2011, 72(3): 259–264 13.Na Zhao, Meng-Xue Ji, Ling Xu and Bian-Sheng Ji*. 3-butyl-6-fluoro-1(3H)-isobenzofuranone (6-F-NBP), a derivative of dl-n-butylphthalide, inhibits glutamate-induced cytotoxicity in PC12 cells. Drug Dev Res. 2012，73：11-17 14.Liu ZZ, Ji BS*. The protective effect of trihexyphenidyl on the beta-amyloid peptide (25-35)-induced cytotoxicity in PC12 cells. Clin Exp Med. 2010，Dec; 10(4):237-243. 15.Bian-Sheng Ji , Ming Li , Ling He Interaction of CJZ3, a lomerizine derivative, with ATPase activity of human P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Pharmazie.2010, 65:1-5 16.Ji BS, He L CJX1, an amlodipine derivative, interacts with ATPaseof human P-glycoprotein.Cell Biol Int. 2009, 33：1073-1078 17.Ji BS, He L The effect of CJX2, an amlodipine derivative, combined with verapamil on P-glycoprotein efflux function in vitro. Drug Dev Res.2009, 70: 445–449 18.Ji BS, Gao Y. Protective effect of trihexyphenidyl on hydrogen peroxide-induced oxidative damage in PC12 cells. Neurosci Lett. 2008,437：50-54 19.Bian-sheng Ji, Ling He. Protective effect of CPUX1, a progesterone, on hydrogen peroxide-induced oxidative damage in PC12 cells. Drug Dev Res. 2008,69 (8): 495-501 20.Ji BS, Ji H, Liu GQ. Doxepin protects cultured neurons against oxidative stress-induced injury. Acta Pharmacol Sin. 2004,Mar;25(3):297-300