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个人简介

1981-1988年在南开大学化学系学习并获得学士和硕士学位,1994-1997在中山大学化学系学习并获得博士学位,曾在日本、美国进修;1988年起一直在河南大学工作。 奖励 1.王超杰,谢松强,王建红,田智勇,程鹏飞,李骞,赵瑾.靶向性多胺缀合物抗肿瘤作用及机制研究。河南省人民政府,河南省科技进步奖,三等奖,2013年 2.赵瑾,王超杰,王建红,甘莹,王玉霞,刘洋,谢松强,闫琳.茄尼醇结构修饰物用于药物开发的基础研究。河南省人民政府,河南省科技进步奖,二等奖,2010年

研究领域

主要从事有机化学和药物化学方面的教学和科研工作

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Fujun Dai, Qian Li, Yuxia Wang,* Chaochao Ge, Chenyang Feng, Songqiang Xie,* Haoying He, Xiaojuan Xu, Chaojie Wang*. Design, Synthesis and Biological Evaluation of Mitochondria-Targeted Flavone-naphthalimide-polyamine Conjugates with Antimetastatic Activity.J Med Chem.2017, 60 (5): 2071-2083 2. Wang Yuxia, Zhang Jianying, Li Meng, Li Ming, Xie Songqiang*, Wang Chaojie*.Synthesis and evaluation of novel amonafide-polyamine conjugates as anticancer agents.Chem Biol Drug Des.2017,89:670–680 3. Wang C,Ruan P,Zhao Y,Li X,Wang J,Wu X,Liu T,Wang S,Hou J,Li W,Li Q,Li J,Dai F,Fang D*,Wang C*,Xie S*.Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.Oncotarget.2017,1,1092-1109 4. Zhiyong Tian, Luyao Zhao, Huanyang Dong, Yan Zhang, Yijuan Zhang, Qianlei Ren, Shuangyu Shao,Yingying Huang,Lina Song, Tao Guo , Xuejun Xu,*, Chaojie Wang*.Study on the interaction of anthracenyl-methyl homospermidineconjugate (ANTMHspd) with DNA by spectroscopic methods.J Photochem Photobiol B.2017,169:27-34 5. Yuan Zhao, Nanhao Chen, Chaojie Wang,* and Zexing Cao*.A Comprehensive Understanding of Enzymatic Catalysis by Hydroxynitrile Lyases with S Stereoselectivity from the α/β-Hydrolase Superfamily: Revised Role of the Active-Site Lysine and Kinetic Behavior of Substrate Delivery and Sequential Product Release.ACS Catalysis.2016, 6, 2145-2157 6. Zhiyong Tian, Yingying Huang, Yan Zhang , Lina Song , Yan Qiao , Xuejun Xu* , Chaojie Wang* Spectroscopic and molecular modeling methods to study the interaction between naphthalimide- polyamine conjugates and DNA.J Photochem Photobiol B.2016,158:1-15 7. Wen Luo*, Ying Chen, Ting Wang, Chen Hong, Li-Ping Chang, Cong-Cong Chang,Ya-Cheng Yang, Song-Qiang Xie , Chao-Jie Wang* Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities. Bioorg. Med. Chem.2016,24,672–680. 8. Wen Luo, Ting Wang, Chen Hong, YaeChen Yang , Ying Chen, Juan Cen*, SongQiang Xie, ChaoJie Wang* Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.Eur. J Med.Chem.2016, 122, 17-26 9. Qian Li, Yangyang Zhai , Wen Luo, * , Zixin Zhu , Xin Zhang , Songqiang Xie* ,Chen Hong , Yuxia Wang, Yabin Su, Jin Zhao, Chaojie Wang. Synthesis and biological properties of polyamine modified flavonoids as hepatocellular carcinoma inhibitors.Eur. J Med Chem..2016, 121, 110-119 10. Tian Z, Zang F, Luo W, Zhao Z, Wang Y, Xu X*, Wang C* .Spectroscopic study on the interaction between mononaphthalimide spermidine (MINS) and bovine serum albumin (BSA).J Photochem Photobiol B.2015, 142:103-9. 11. Tian ZY, Song LN, Zhao Y, Zang FL, Zhao ZH, Chen NH, Xu XJ*, Wang CJ*.Spectroscopic Study on the Interaction between Naphthalimide-Polyamine Conjugates and Bovine Serum Albumin (BSA). Molecules.2015, 20, 16491-16523 12. Xin Zhang, Jiang Wang, Chen Hong, Wen Luo*,Chaojie Wang*, Design, synthesis and evaluation of genistein polyamine conjugates as multi-functional anti-Alzheimer agents,Acta Pharm. Sinica B,2015,22,67 13. Chen L, Kang QH, Chen Y, Zhang YH, Li Q, Xie SQ*, Wang CJ*.Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells. Oncol Rep.2014,31(2):737-44. 14. Mei-Xia Zhao,* Er-Zao Zeng, Yang Li and Chao-Jie Wang*.A study on effects of naphthalimide derivative-capped quantum dots on the cellular internalization, proliferation, and apoptosis ability.J. Mater. Chem. B,2014,2, 7351–7359 15. Tian ZY, Li JH, Li Q, Zang FL, Zhao ZH, Wang CJ.Study on the synthesis, biological activity and spectroscopy of naphthalimide-diamine conjugates.Molecules.2014;19(6):7646-68 16. Mei-Xia Zhao,* Yang Li, Er-Zao Zeng, and Chao-Jie Wang*.The Application of CdSe Quantum Dots with Multicolor Emission as Fluorescent Probes for Cell Labeling.Chem. Asian J.2014, 9, 1349–1355 (封底文章) 17. Chen Hong, Wen Luo*, Dong Yao, Ya-Bin Su, Xin Zhang, Run-Guo Tian, Chao-Jie Wang*. Novel aromatic–polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. Bioorg. Med. Chem.2014, 22,3213–3219 18. Zhiyong Tian*, Zhonghua Zhao, Fenglei Zang, Yueqiao Wang, Chaojie Wang*. Spectroscopic study on the interaction between naphthalimide–polyamine conjugates and DNA. J Photochem Photobiol B.2014,138,202–210 19. Kuo-xi Xu∗,Shu-yan Jiao,Wen-yong Yao, Hua-jie Kong, Jing-lai Zhang, Chao-jie Wang∗.Syntheses and highly enantioselective fluorescent recognition of hydroxyl/amino carboxylic acid anions in protic solutions.Sensors and Actuators Bchemical.2013,177,384– 389 20. Wen Luo*, Ya-Bin Su, Chen Hong, Run-Guo Tian, Lei-Peng Su, Yue-Qiao Wang, Yang Li, Jun-Jie Yue, Chao-Jie Wang*. Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents. Bioorg. Med. Chem.2013, 21, 7275–7282

学术兼职

河南大学学术委员会和学位委员会委员,河南省化学会常务理事,副秘书长,“精细化工中间体”、“化学研究”、“河南大学学报(自然版)”编委

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