韩根成 - 河南大学 - 抗体药物开发技术国家地方联合工程实验室

个人简介

2002年毕业于第三军医大学，获免疫学专业博士学位；2005-2007年在美国路易斯维尔大学从事博士后研究。2002年至今先后任军事医学科学院基础医学研究所助理研究员、副研究员、研究员。

研究领域

一直从事免疫调控异常与疾病的关系研究。早期围绕不同T辅助细胞亚群的调控机制及其在免疫耐受诱导中的应用展开研究，阐明了抗原的不同耐受诱导途径对T细胞亚群分化的影响及意义。近期重点聚焦于免疫细胞稳态调控的机制及意义研究。发现了一些在T细胞及天然免疫细胞稳态调控中发挥关键作用的免疫检查点分子，重点阐明了它们在天然免疫细胞稳态调控中的信号通路，研发了相应的抗体等干预制剂，为后续的应用研究奠定了扎实的理论及实验基础。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Wang Z, Sun D, Chen G, Li G, Dou S, Wang R, Xiao H, Hou C, Li Y, Feng J, Shen B, Han G*. Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2. Scientific Reports. 2017 Feb 16; 7: 42095. 2.Li Y, Zhou T, Wang Y, Ning C, Lv Z, Han G*, Morris JC, Taylor EN, Wang R, Xiao H, Hou C, Ma Y, Shen B, Feng J, Guo R, Li Y, Chen G. The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation. Oncogene. 2017 Feb 20. doi: 10.1038/onc.2017.2. 3.Zhang Y, Wang Z, Xiao H, Liu X, Zhu G, Han G, Chen G, Hou C, Ma N, Shen B, Li Y, Wang T, Wang R. Foxd3 suppresses IL-10 expression in B cells. Immunology 2017. Apr. 150(4): 478-488. 4.Ma N, Zhang Y, Liu Q, Wang Z, Liu X, Zhu G, Yu D, Han G, Chen G, Hou C, Wang T, Ma Y, Shen B, Li Y, Xiao H*, Wang R*. B-cell Activating Factor (BAFF) selected IL-10-B cells over IL-10+B Cells in inflammatory response. Mol Immunol. 2017. Feb. 85: 18-26. 5.Jiang X, Zhou T, Xiao Y, Yu J, Dou S, Chen G, Wang R, Xiao H, Hou C, Wang W, Shi Q, Feng J, Ma Y, Shen B, Li Y, Han G*. Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. OncoImmunology. 2016. Aug 3, 5(9): e1211219. 6.Wang X, Liu X, Zhang Y, Wang Z, Zhu G, Han G, Chen G, Hou C, Wang T, Ma N, Shen B, Li Y, Xiao H*, Wang R*. Interleukin (IL)-39 [IL-23p19/Epstein–Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. Clin Exp Immunol. 2016 Nov. 186 (2): 144-156. 7.Liu X, Zhang Y, Wang Z, Wang X, Zhu G, Han G, Chen G, Hou C, Wang T, Shen B, Li Y, Ma N, Xiao H*, Wang R*. Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis. Int J Oncol. 2016 Oct. 49 (4): 1469-1478. 8.Wang X, Wei Y, Xiao H, Liu X, Zhang Y, Han G, Chen G, Hou C, Ma N, Shen B, Li Yan, Egwuagu CE*, Wang R. Novel IL-23p19/Ebi3 (IL-39) Cytokine Mediates Inflammation in Lupus-like Mice. Eur J Immunol. 2016 Jun; 46(6): 1343-50. 9.Wang X, Wei Y, Xiao H, Liu X, Zhang Y, Han G, Chen G, Hou C, Zhang L, Ma N, Shen B, Li Y, Egwuagu CE, Wang R. Pre-existing CD19-independent GL7- Breg cells are expanded during inflammation and in mice with lupus-like disease. Mol Immunol. 2016 Mar; 71: 54-63. 10.Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J, Ma Y, Shen B, Wang L, Li Y, Han G*. Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages. Clin Immunol. 2015 Jul 21; 160: 328–335. 11.Li J, Li M, Su L, Wang H, Xiao K, Deng J, Jia Y, Han G* Xie L.Alterations of T helper lymphocyte subpopulations in sepsis, severe sepsis, and septic shock: a prospective observational study. Inflammation. 2015 Jun;38(3):995-1002. 12.Ren F, Li J, Jiang X, Xiao K, Zhang D, Zhao Z, Ai J, Hou C, Jia Y, Han G*, Xie L. Plasma soluble Tim-3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim-3 on monocytes. Tissue Antigens. 2015 Nov;86(5):325-32. 13.Ning C, Li YY, Wang Y, Han GC*, Wang RX, Xiao H, Li XY, Hou CM, Ma YF, Sheng DS, Shen BF, Feng JN, Guo RF, Li Y, Chen GJ. Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis. Mucosal Immunol. 2015 Nov; 8(6): 1275-84. 14.Ma N, Liu X, Xing C, Wang X, Wei Y, Han G, Chen G, Hou C, Shen B, Li Y, Xiao H*, Wang R*. Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells. Clin Immunol. 2015 Jun 9; 160(2): 142-154. 15.Wang X, Wei Y, Liu X, Xing Chen, Han G, Chen G, Hou C, Dambuza IM, Shen B, Li Yan, Xiao H，Wang R. IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. Mol Immunol. 2015 Aug; 66(2): 402-8. 16.Wang X, Xiao H, Wei Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*. Blockade of B-cell activating factor (BAFF) with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in EAE mice. Central Eur J Immunol. 2015. 40 (2): 142-148 17.Xing C, Ma N, Xiao H, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Wang R. Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis. J Leukoc Biol. 2015 Mar; 97(3):547-56. 18.He Y, Ma N, Xing C, Wang X, Xiao H, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Jiang Z, Wang R, Wu W. Novel IL-6-secreting γδT (γδT6) cells increased in patients with atherosclerotic cerebral infarction. Mol Med Rep. 2015 Feb; 11(2): 1497-503. 19.Zhao Z, Jiang X, Kang C, Xiao Y, Hou C, Yu J, Wang R, Xiao H, Zhou T, Wen Z, Feng J, Chen G, Ma Y, Shen B, Li Y, Han G*. Blockade of the Tim-3 pathway exacerbates sepsis-induced immune deviation and immunosuppression. Clin Exp Immunol. 2014 Nov. 178 (2): 279-91. 20.Guo X, Jiang X, Xiao Y, Zhou T, Guo Y, Wang R, Zhao Z, Xiao H, Hou C, Ma L, Lin Y, Lang X, Feng J, Chen G, Shen B, Han G*, Li Y. IL-17A signaling in colonic epithelial cells inhibits pro-inflammatory cytokine production by enhancing the activity of ERK and PI3K. PLoS One. 2014. 9: e89714.

学术兼职

中国免疫学会基础免疫学分会委员；《细胞与分子免疫学杂志》编委，《中国肿瘤生物治疗杂志》编委；Journal of Immunology, Cellular Molecular Immunology 等杂志的审稿人