个人简介
受教育经历
1982.09-1987.06 河南医科大学临床医学系,学士
2000.09-2003.06 郑州大学医学院,外科学,硕士
2005.09-2008.06 中南大学湘雅医学院,外科学,博士
工作经历
1987.09-1994.04 河南大学淮河医院普外科,住院医师
1994.04-2000.03 河南大学淮河医院普外科,主治医师
2000.04-2005.03 河南大学淮河医院普外科,副主任医师、副教授
2005.03至今 河南大学淮河医院, 主任医师,外科副主任
2006.05至今 河南大学,教授
2010.02-2013.02 河南大学淮河医院,副院长
2013.03-2018.05 河南大学淮河医院,主任医师,教授,院党委书记
2018.05至今 河南大学医学院副书记 常务副院长
获得奖励
河南省科技进步三等奖,2018
河南省教育厅科技进步二等奖,2018
河南省卫生计生科技创新型人才“51282”工程领军人才,2015年
全国医药卫生系统创先争优活动先进个人,2014年
研究领域
在消化系统肿瘤的临床诊治方面积累了丰富的临床经验,尤其在肝门部胆管癌、胰腺癌、结直肠癌的手术治疗上具有独到的心得和良好的效果。近年来致力于精准和微创理念在普外科中应用和推广,能熟练行腹腔镜下结肠癌根治术、腹腔镜下肝切除术、腹腔镜胰体尾切除术等,取得良好的临床效果。
致力于转化医学研究,牵头成立了中国循证医学中心网上合作河南分中心、河南大学循证医学中心,河南大学循证医学与临床转化研究院,在循证医学方法学及大数据挖掘方面造诣颇深。
近期论文
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[1] Zuo S, Dai G, Wang L, et al. Suppression of angiogenesis and tumor growth by recombinant T4 phages displaying extracellular domain of vascular endothelial growth factor receptor 2. Archives of virology. 2019;164(1):69-82. doi:10.1007/s00705-018-4026-0
[2] Zuo S, Dai G, Ren X. Identification of a 6-gene signature predicting prognosis for colorectal cancer. Cancer cell international. 2019;19:6. doi:10.1186/s12935-018-0724-7
[3] Wang CY, Li BH, Ma LL, et al. The Top-100 Highly Cited Original Articles on Drug Therapy for Ventilator-Associated Pneumonia. Frontiers in pharmacology. 2019;10:108. doi:10.3389/fphar.2019.00108
[4] Li BH, Wang Y, Wang CY, Zhao MJ, Deng T, Ren XQ. Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2018;24:8105-14. doi:10.12659/msm.913307
[5] Yang S, Zhang H, Ren X. The application of high-field magnetic resonance perfusion imaging in the diagnosis of pancreatic cancer. Medicine. 2017;96(36):e7571. doi:10.1097/md.0000000000007571
[6] Xie YZ, Ma WL, Meng JM, Ren XQ. Knockdown of ZFPL1 results in increased autophagy and autophagyrelated cell death in NCIN87 and BGC823 human gastric carcinoma cell lines. Molecular medicine reports. 2017;15(5):2633-42. doi:10.3892/mmr.2017.6300
[7] Wang LN, Wang F, Liu J, Jin YH, Fang C, Ren XQ. CYP1A1 Ile462Val Polymorphism Is Associated with Cervical Cancer Risk in Caucasians Not Asians: A Meta-Analysis. Frontiers in physiology. 2017;8:1081. doi:10.3389/fphys.2017.01081
[8] Liu J, Yu GZ, Cheng XK, Li XD, Zeng XT, Ren XQ. LGR5 promotes hepatocellular carcinoma metastasis through inducting epithelial-mesenchymal transition. Oncotarget. 2017;8(31):50896-903. doi:10.18632/oncotarget.15143
[9] Li H, Deng J, Yue Z, Zhang Y, Sun H, Ren X. Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system. European journal of clinical pharmacology. 2017;73(2):251-3. doi:10.1007/s00228-016-2161-7
[10] He Z, Dong W, Hu J, Ren X. AQP5 promotes hepatocellular carcinoma metastasis via NF-kappaB-regulated epithelial-mesenchymal transition. Biochemical and biophysical research communications. 2017;490(2):343-8. doi:10.1016/j.bbrc.2017.06.046
[11] Cheng XK, Wang XJ, Li XD, Ren XQ. Genetic association between the cyclin-dependent kinase inhibitor gene p27/Kip1 polymorphism (rs34330) and cancer susceptibility: a meta-analysis. Scientific reports. 2017;7:44871. doi:10.1038/srep44871
[12] Xie Y, Li F, Ren X. Application value of sentinel lymph node biopsy in the radical operation for Stage II advanced gastric cancer. Journal of cancer research and therapeutics. 2016;12(Supplement):57-9. doi:10.4103/0973-1482.191632
[13] Wang CY, Zhang JJ, Hua L, Yao KH, Chen JT, Ren XQ. MicroRNA-98 suppresses cell proliferation, migration and invasion by targeting collagen triple helix repeat containing 1 in hepatocellular carcinoma. Molecular medicine reports. 2016;13(3):2639-44. doi:10.3892/mmr.2016.4833
[14] Chen J, Zhang J, Wang C, et al. Safety of implanting sustained-release 5-fluorouracil into hepatic cross-section and omentum majus after primary liver cancer resection. International journal of immunopathology and pharmacology. 2016;29(3):475-9. doi:10.1177/0394632016648176
[15] Xie YZ, Fang K, Ma WL, Shi ZH, Ren XQ. Risk of postoperative deep venous thrombosis in patients with colorectal cancer treated with open or laparoscopic colorectal surgery: a meta-analysis. Indian journal of cancer. 2015;51 Suppl 2:e42-4. doi:10.4103/0019-509x.151992
[16] Ren X, Ma W, Lu H, et al. Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies. Cancer immunology, immunotherapy : CII. 2015;64(12):1517-29. doi:10.1007/s00262-015-1757-6
[17] Hu JH, Tang HN, Ma YP, et al. Systemic analysis on laparoscope-assisted gastrectomy for patients with gastric cancer. Asian Pacific journal of cancer prevention : APJCP. 2015;16(5):2027-9.
[18] An L, Liu J, Li WW, et al. Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice. Genetics and molecular research : GMR. 2015;14(4):17244-51. doi:10.4238/2015.December.16.24
[19] Yao K, Ma Y, Ma W, et al. Shenqifuzheng injection combined with chemotherapy in the treatment of advanced gastric cancer: a systematic review and meta-analysis. Journal of cancer research and therapeutics. 2014;10 Suppl 1:70-4. doi:10.4103/0973-1482.139768
学术兼职
世界内镜医师协会副会长,华夏医学科技奖理事会常务理事、中国医疗保健国际交流促进会循征医学分会副主任委员、中国抗癌协会肿瘤微创专业委员会委员及肿瘤微创与生物治疗分会副主任委员、中华预防医学会循证预防医学专业委员会常委、中国医疗保健国际交流促进会外科分会常委、中国研究型医院协会常务理事及微创外科学专业委员会委员、河南省预防医学会循证预防医学专业委员会副主任委员、河南省抗癌协会常务理事、河南省中西医结合循证医学专业委员会副主任委员。《中国内镜杂志》、《河南外科学杂志》常务编委,《腹腔镜外科杂志》编委,《中国循证医学杂志》编委