个人简介

Ph.D., University of Rochester

研究领域

Macromolecular engineering/evolution/and discovery

Macromolecular agents offer unique opportunities for advances in a multitude of areas, which include catalysis and medicine. Researchers in the McNaughton lab apply methods in protein engineering and high-throughput screening to develop new reagents capable of binding and modulating cellular receptors that evade small molecule control. These efforts are dovetailed with the development of genetically-defined nanocarriers that target the intracellular delivery of functional protein therapeutics or imaging reagents to diseased cells. Studies in these areas typically span the application of molecular biology-based approaches to the discovery of new protein drug leads, and assessment of their therapeutic efficacy in mammalian cells and in vivo (mice). Additionally, we apply engineering, evolution, and high-throughput screening methods to identify novel macromolecular catalysts.

近期论文

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Crawford, D.W.; Blakeley, B.D.; Chen, P.-H.; Laird-Offringa, I.A.; McNaughton, B.R. "Synthetic RNA Recognition Motifs That Potenly and Selectively Bind TAR RNA and Disrupt the TAT/TAR Interaction" (in preparation) Chapman, A.M.; McNaughton, B.R. "Synthetic Proteins Bind the Oncoprotein Gankyrin, Disrupt Its Interaction with S6 ATPase, and Suppress Gankyrin-Dependent Ubiquitination of p53" (submitted) Walker, S.N.; Tennyson, R.L.; Chapman, A.M.; Kennan, A.J.; McNaughton, B.R. "GLUE That Sticks to HIV: A Helix-Grafted GLUE Protein That Selectively Binds HIV gp41 N-terminal Helical Region" ChemBioChem 2015, 16, 219. Chapman, A.M.; Rogers, B.E.; McNaughton, B.R. "Characterization of the Binding Interaction Between the Oncoprotein Gankyrin and a Grafted S6 ATPase" Biochemistry 2014, 53, 6857. Chapman, A.M.; McNaughton, B.R. "Resurfaced Shape-Complementary Proteins That Selectively Bind the Oncoprotein Gankyrin" ACS Chemical Biology 2014, 9, 2223. DePorter, S.M.; McNaughton, B.R. "Engineered M13 Bacteriophage Nanocarriers for Intracellular Delivery of Exogenous Proteins to Human Prostate Cancer Cells" Bioconjugate Chemistry 2014, 25, 1620. This work was listed as a ‘most read’ paper Mohan, U.; Burai, R.; McNaughton, B.R. "Reactivity Between Acetone and Single-Stranded DNA Containing a 5’-Terminated 2’-Fluoro-N7-Methyl Guanine" Tetrahedron Letters 2014, 55, 3358. Blakeley, B.D.; McNaughton, B.R. "Synthetic RNA Recognition Motif Proteins that Selectively Recognize HIV-1 Trans-Activation Response Element Hairpin RNA" ACS Chemical Biology 2014, 9, 1320. DePorter, S.M; Lui, I.; Bruce, V.J.; Gray, M.A.; Lopez-Islas, M.; McNaughton, B.R. "Mutagenesis Modulates the Uptake Efficiency, Cell-Selectivity, and Functional Enzyme Delivery of a Protein Transduction Domain" Molecular BioSystems 2014, 10, 18. This work was listed as a 'most read' paper. Blakeley, B.D.; Shattuck, J.; Coates, M.B.; Tran, E.; Laird-Offringa, I.A.; McNaughton, B.R. "Analysis of Protein - RNA Complexes Involving an RNA Recognition Motif Engineered to Bind RNA Hairpins with 7- and 8-Nucleotide Loops" Biochemistry 2013, 52, 4745. This work was listed as a 'most read' paper. Mohan, U.; Burai, R.; McNaughton, B.R. "In Vitro Evolution of a Friedel-Crafts Deoxyribozyme" Organic & Biomolecular Chemistry 2013, 11, 2241. DePorter, S.M.; Lui, I.; Mohan, U.; McNaughton, B.R. "A Protein Transduction Domain with Cell Uptake and Selectivity Profiles that Are Controlled by Multivalency Effects" Chemistry & Biology 2013, 20, 434. This work was featured in SciBX (volume 6, number 18, 2013) DePorter, S.M.; Hendricks, N.K.; Gray, M.A.; McNaughton, B.R. "A One-Pot Synthesis of Micron-Sized and Nanoscale Poly(N-acryloxysuccinimide-co-N-vinylpyrrolidone) Particles" Tetrahedron Letters 2012, 53, 6436. This work is highlighted on the cover of this issue. DePorter, S.M.; Lui, I; McNaughton, B.R. "Programmed Cell Adhesion and Growth on Cell-Imprinted Polyacrylamide Hydrogels" Soft Matter 2012, 8, 10403. Blakeley, B.D.; DePorter, S.M.; Mohan, U.; Burai, R.; Tolbert, B.S.; McNaughton, B.R. "Methods for Identifying and Characterizing Interactions Involving RNA" Tetrahedron 2012, 68, 8837. Blakeley, B.D.; Chapman, A.M.; McNaughton, B.R. "Split-Superpositive GFP Reassembly is a Fast, Efficient, and Robust Method for Detecting Protein-Protein Interactions In Vivo" Molecular BioSystems 2012, 8, 2036. (plasmids encoding split-superpositive GFP fragments can be purchased through Addgene) This work was listed as a 'most read' paper. Burai, R.; Chatwichien, J.; McNaughton, B.R. "A Programmable Build - Couple Approach to the Synthesis of Heterofunctionalized Polyvalent Molecules" Organic & Biomolecular Chemistry 2011, 9, 5056.