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个人简介

教育经历 1986毕业于第四军医大学医学系 1993毕业于军事医学科学院基础所(三所),获硕士学位 1999毕业于第四军医大学生物化学与分子生物学系,获博士学位 工作经历 1999-2003第四军医大学讲师,肿瘤生物学国家重点实验室 2003-2008第四军医大学副教授,肿瘤生物学国家重点实验室 (其间, 2003-2007加拿大Saskatchewan大学,博士后,获得省健康研究基金全额资助) 2008-2011加拿大Saskatchewan大学,research associate,实验室负责人 2012河南大学特聘教授,黄河学者,教授(兼职Saskatchewan大学,research associate,) 2012河南省生理学会常务理事、神经生物学专业委员会副主委 2012河南省生物化学与分子生物学学会常务理事 1999中国生物化学与分子生物学会会员 获奖情况 1996军队科技进步二等奖,“高热引起热损伤的肾上腺素受体机理及抗热损伤研究”,第五完成人 1999军队科技进步一等奖“蛋白酪氨酸激酶Btk在细胞内外与蛋白激酶PKC相互作用的研究”,第三完成人 1999第四军医大学教学先进个人,2001第四军医大学教学先进个人 2001陕西省优秀博士论文获得者

研究领域

分子生物学/PTEN调控的细胞信号转导(肿瘤生物学);非编码RNA参与的基因表达与调控; Sirt2 调控少突胶质细胞分化

近期论文

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1.Fang N, Gu T, Wang Y, Wang S, Wang F, An Y, Wei W, Zhang W, Guo X, Nazarali AJ,Ji S*.Expression of PTEN-long mediated by CRISPR/Cas9 can repress U87 cell proliferation.J Cell Mol Med. 2017 Jun 19. doi: 10.1111/jcmm.13236. [Epub ahead of print] 2.Wei W, Ji X, Guo X,Ji S*.Regulatory Role of N6 -Methyladenosine(m6 A) Methylationin RNA Processing and Human Diseases.J Cell Biochem. 2017 Mar 3. doi: 10.1002/jcb.25967. [Epub ahead of print]) 3.Wei W, Wang H,Ji S*.Paradoxes of the EphB1 receptor in malignant brain tumors. Cancer Cell Int. 2017 Feb 8;17:21. doi: 10.1186/s12935-017-0384-z. 4.Thangaraj MP, Furber KL, Gan JK,Ji S, Sobchishin L, Doucette JR, Nazarali AJ. RNA binding protein Quaking stabilizes Sirt2 mRNA during oligodendroglial differentiation. J Biol Chem. 2017 Feb 10. pii: jbc.M117.775544. doi: 10.1074/jbc.M117.775544. 5.Di Y, Ji S, Wolf P, Krol ES, Alcorn J. Enterolactone glucuronide and β-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment. AAPS PharmSciTech. 2017 Jan 23. doi: 10.1208/s12249-017-0721-5. 6.Yang An, Haojie Wang, Jingyao Jie, Yitai Tang, Weijuan Zhang,Shaoping Ji*, Xiangqian Guo*. Identification of distinctmolecular subtypes of uterine carcinosarcoma Oncotarget,Oncotarget.2017 Feb 2. doi: 10.18632/oncotarget.15032. [Epub ahead of print] 7.Yang An,Kendra L.Furber,Shaopig Ji*. Pseudogenes Regulate Parental Gene Expression via ceRNA Network. Journal of Cellular and Molecular Medicine. 2016 Aug 25. doi: 10.1111/jcmm.12952. [Epub ahead of print] 8.Shaoping Ji, Doucette JR, Nazarali AJ.Protocols for Cloning, Expression, and Functional Analysis of Sirtuin2(SIRT2).Methods Mol Biol. 2016;1436:189-99. doi: 10.1007/978-1-4939-3667-0_13. 9.Fengling Wang, Adil J. Nazarali,Shaoping Ji*. Circular RNAs as potential biomarkers for cancer diagnosis and therapy. American Journal of Cancer Research. 2016, 6(6):1167-1176 10.Wenqiang Wei, Hongju Wang, Xiaoya Li, Na Fang, Shili Yang, Hongyan Liu, Xiaonan Kang, Xiulian Sun, andShaoping Ji*, Cloning and Characterization of Sf9 Cell Lamin and the Lamin Conformational Changes during Autographa californica multiple nucleopolyhedrovirus Infection. Viruses 2016, 8, 126; doi: 10.3390/v8050126 11.Fang N, Zhong N, Yang Y, Guo Y,Ji S*.Data of expression and purification of recombinant Taq DNA polymerase.Data Brief. 2016 Aug 20; 9:81-4. doi: 10.1016/j.dib.2016.08.032. eCollection 2016 Dec. 12.Yamei Hu, Yang An, Na Fang, Yanzhang Li, Haiying Jin, Adil Nazarali,Shaoping Ji*.The Optimization of Soluble PTEN Expression in Escherichia coli.The Open Biochemistry Journal, 2015, 9: 42-48 13.Wang J, Sun Z, Shen J, Wu D, Liu F, Yang R,Ji S, Ji A, Li Y.Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB.Oxid Med Cell Longev. 2015; 970156. 14.Wu D, Zheng N, Qi K, Cheng H, Sun Z, Gao B, Zhang Y, Pang W, Huangfu C,Ji S, Xue M, Ji A, Li Y.xogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential.Med Gas Res. 2015;5(1):1. 15.Wang J, Wang S, Li M, Wu D, Liu F, Yang R,Ji S, Ji A, Li Y.The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress.PLoS One. 2015 Nov 10;10(11): e0142571. 16.Yinguo Bai, Na Fang, Tingxun Gu, Yuhua Kang, Jiang Wu, Desheng Yang, Hui Zhang, Zhimin Suo andShaoping Ji*.HOXA11 gene is hypermethylation and aberrant expression in gastric cancer.Cancer Cell International 2014 Aug 19;14:79 17.Wang T, Jia L, Yang G,Ji S, Yao L, Zhang B.Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells.Mol Cell Biochem. 2011 Apr;350(1-2):177-83. 18.Shaoping Ji, Ronald Doucette, and Adil J. Nazarali. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.J Mol Cell Biol.2011;3(6):351-9 19.Jia L,Ji S(co-first author), Maillet JC, Zhang X.PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3-kinase and MAP kinase signaling.J Cell Biochem.2010; 111(6):1390-400. 20.Dang N, Hu J, Liu X, Li X,Ji S, Zhang W, Su J, Lu F, Yang A, Han H, Han W, Jin B, Yao L.CD167 acts as a novel costimulatory receptor in T-cell activation.J Immunother. 2009 Oct;32(8):773-84.

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