任志广 - 河南大学 - 基础医学院

个人简介

2005年9月-2009年7月：河南大学生命科学学院生物技术专业本科 2009年9月-2012年7月：河南大学医学院微生物学专业硕士研究生 2012年9月-2015年7月：北京协和医学院免疫学专业获医学博士学位 2015年7月至今：河南大学基础医学院抗体药物开发技术国家地方联合工程实验室获奖情况（1）基于ABCG2肿瘤多药耐药机制及其逆转剂的研究：中国人民解放军军事医学科学院基础医学研究所2010优秀论文（2）替尼类药物耐药机制及NO供体型化合物克服肿瘤耐药研究：河南省2012年优秀硕士毕业论文（3）河南大学2016-2017教学质量二等奖，河南大学2017-2018教学质量二等奖

研究领域

主要从事流感病毒新型疫苗、病毒样颗粒疫苗、诊断抗体试剂及肿瘤耐药机理等研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

（1）Zhiguang Ren,et al.Inclusion of membrane-anchored LTB or flagellin protein in H5N1 virus-like particles enhances protective responses following intramuscular and oral immunization of mice,Vaccine.2018.08.053. （2）Zhiguang Ren,et al.Intramuscular and intranasal immunization with an H7N9influenza virus-like particle vaccine protects mice against lethal influenza virus challenge,International Immunopharmacology58 (2018) 109–116. （3）Zhiguang Ren,et al.Anticancer efficacy of a nitric oxide-modified derivative of bifendate against multidrug-resistant cancer cells.J. Cell. Mol. Med.2016，20（6）：1095-1105. （4）Zhiguang Ren, et al.H5N1 Influenza Virus-Like Particle Vaccine Protects Mice from Heterologous Virus Challenge better than Whole Inactivated Virus.Virus Research.2015; 16;200:9-18. （5）Xiaoke Gu#,Zhiguang Ren#(Co-first author), et al. Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e] azepine scaffold as potent P-glycoprotein inhibitors.Eur J Med Chem.2012; 51:137-44. （6）Jing Liu, Zhiguang Ren, et al. Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses,International Immunopharmacology,63 (2018) 119–128. （7）Xiaoke Gu,Zhangjian Huang,Zhiguang Ren, et al.Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivativesagainst Drug-Resistant K562/A02 Cells in Vitro and in Vivo.J Med Chem.2017.2.9,60(3):928~940. （8）Kun Zhang,…,Zhiguang Ren, et al.The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection.Oncotarget.2017; 8:30422-30437. doi: 10.18632/oncotarget.16503. （9）Xianliang Ji,ZhiguangRen, et al.Intranasal Immunization with Influenza Virus-Like ParticlesContaining Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances AdaptiveImmune Responses and Protection against an Antigenically DistinctVirus.Viruses-Basel,2016,8（4）:1-16 （10）Xiaoke Gu,Zhiguang Ren, et al. Bifendate-chalcone hybrids: a new class of potential dual inhibitors of P-glycoprotein and breast cancer resistance protein.Biochem Biophys Res Commun. 2014,12;455;318-22. （11）Xiaoke Gu,Zhiguang Ren, et al. Synthesis and Biological Evaluation of Bifendate- Chalcone Hybrids as a New Class of Potential P-glycoprotein Inhibitors.Bio Med Chem. 2012,2540-2548. （12）Xiaobo Tang, Xiaoke Gu,Zhiguang Ren, et al. Synthesis and Evaluation of Substituted Dibenzo [c,e]azepine-5-ones as P-glycoprotein-mediated Multidrug Resistance Reversal Agents.Bio & Med Chem Lett22(2012);2675-2680. （13）Yinxiang Wei, Yuanfang Ma, Qing Zhao,Zhiguang Ren, et al. New Use for an Old Drug: Inhibiting ABCG2 with Sorafenib.Mol Cancer Ther; (2012) 11(8). （14）Xiaoyu Sang,…,Zhiguang Ren, et al.Rapid emergence of a PB2-E627K substitution confers a virulent phenotype to an H9N2 avian influenza virus during adaption in mice.Archives of Virology.2015, 160,5; 1267-1277.