个人简介
教育背景
1990-1994 学士，生物化学，山东大学
1994-1997 硕士毕业文凭，发育生物学，中国科学院上海细胞生物学研究所
1998-2001 博士，分子细胞发育生物学，美国衣阿华州立大学
工作经历
1997-2001 博士研究生研究助理，美国爱荷华州立大学
2001-2005 博士后研究助理，美国洛克斐勒大学
2005-2011 助理教授， 美国宾州州立大学
2011-现在 副教授（终身职称）, 美国宾州州立大学.
2016-现在 Helios Biotechnology & Pharmaceuticals, LLC，创始人
2018-现在 河南大学特聘教授
获奖情况
2014 ECoS’ Lab Bench to Commercial Innovation Grant
2014 PBCC’s breast and cervical cancer research grant award
2012 PSU Inventor Incentive Award
2009 PSU Clinical and Translational Science Institute Pilot Grant Award
2006 Johnson & Johnson and PSU Innovative Technology Research Seed Grant Award
近期论文
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1. Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H, Reeves WB. (2017) Neutrophil peptidylarginine deiminase 4 has a pivotal role in ischemia/reperfussion-induced acute kidney injury. Kidney Int. pii: S0085-2538(17)30611-7. doi: 10.1016/j.kint.2017.08.014. [Epub ahead of print]
2. Pan B, Alam HB, Chong W, Mobley J, Liu B, Deng Q, Liang Y, Wang Y, Chen E, Wang T, Tewari M, Li Y. CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock. (2017) Sci Rep. 2017 Aug 21;7(1):8972. doi: 10.1038/s41598-017-09337-4.
3. Saha P, Yeoh BS, Olvera RA, Xiao X, Singh V, Awasthi D, Subramanian BC, Chen Q, Dikshit M, Wang Y, Parent CA, Vijay-Kumar M. (2017) Bacterial siderophores hijack neutrophil functions. J Immunol. 198(11):4293-4303.
4. Klionsky DJ et al. …Wang Y… (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222. (Cited 4006 times, not included in the total count)
5. Vollger L, Akong-Moore K, Cox L, Goldmann O, Wang Y, Schafer S, Naim H, Nizet V, von Kockritz-Blickwede M (2016) Iron chelating agents desferrioxamine and L-mimosine stimulate neutrophil extracellular traps (NETs) 36(3). pii: e00333. DOI: 10.1042/BSR20160031.
6. Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD (2016) Priming of neutrophils toward netosis promotes tumor growth. OncoImmunology. 5(5):e1134073.DOI:10.1080/2162402X.2015.1134073 (Cited 7 times)
7. Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Lougharn P, Mowen K, Wang Y, Simmons RL, Huang H, Tsung A. (2016) Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. Cancer Res. 76(6):1367-80 (Cited 60 times)
8. Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Jin P, Wu GY, Chen G. Small molecules efficiently reprogram human astroglial cells into functional neurons. (2015) Cell Stem Cell. 17:735-747. PMID: 26481520
9. He W, Zhou P, Chang Z, Liu B, Liu X, Wang Y, Li Y, Alam HB. Inhibition of peptidylarginine deiminase attenuates inflammation and improves survival in a rat model of hemorrhagic shock. (2015) Journal of Surgical Research. 200:610-618. PMID: 26434505
10. Wong SL, Martinod K, Demers M, Gallant M, Wang Y, Kahn CR, and Wagner DD (2015) Diabetes primes neutrophils to undergo NETosis which severely impairs wound healing. Nature Medicine 21:815-819. PMCID: PMC4631120 (Cited 160 times)
11. Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, and Wang Y (2015) ATF4 gene network mediate cellular response to the anticancer PAD4 inhibitor YW3-56. Molecular Cancer Therapeutics 14:877-888. PMID: 25612620 (Cited 9 times)
12. Huang H, Thome S, Al-Khafaji AB, Tai S, Loughran P, Chen L, Kim J, Billiar T, Wang Y, Tsung A (2015) DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology. 62:600-614. PMID: 25855125 (Cited 77 times)
13. Chen XA, Sun J, Wang Y. (2015) Techniques Analyzing Chromatin Modifications at Specific Loci. Epigenetic Technological Applications. 79-103.
14. Martinod K, Fuchs TA, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD (2015) PAD4-deficiency does not worsen polymicrobial sepsis mortality and ameliorates endotoxemia. Blood 125:1948-56. PMID: 25624317 (Cited 56 times)
15. Sabulski MJ, Wang Y, Pires MM (2015) PAD2 activity monitored via a fluorescent substrate analog. Chemical Biology & Drug Design. 86:599-605. PMID: 25643806
16. Chang GS, Chen XA, Park B, Rhee HS, Li P, Han KH, Mishra T, Chan-Salis KY, Li Y, Hardison RC, Wang Y, Pugh BF (2014) A comprehensive and high resolution genome-wide response of p53 to stress. Cell Report 24:514-27.
17. Li Y, Liu Z, Liu B, Zhao T, Chong W, Wang Y, and Alam HB (2014) Citrullinated histone H3 – a novel target for treatment of sepsis. Surgery. 156:229-34. (Cited 14 times)
18. Jerjomiceva N, Seri H, Vollger L, Wang Y, Zeitouni N, Naim HY, von Kockritz-Bickwede M (2014) Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes. J. Innate Immunity. 6:706-12.
19. Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, Wang Y, Beebe DJ, Robinson WH, Huttenlocher A (2014) Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis. Arthritis & Rheumatism. 66:1482-91. (Cited 19 times)
20. Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD (2014) VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood 23:141-8. (Cited 81 times)
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