个人简介

Ph.D., University of Wisconsin-Madison

研究领域

Peptide/Protein Recognition and Design

Molecular recognition, self-assembly, development of novel biological recognition motifs, construction of synthetic receptors for small molecules of biological interest, design of catalytic peptides.

近期论文

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Walker, S. N.; Tennyson, R. L.; Chapman, A. M.; Kennan, A. J.*; McNaughton, B. R.* "GLUE That Sticks to HIV: A Helix-Grafted GLUE Protein That Selectively Binds HIV gp41 N-Terminal Helical Region" ChemBioChem, 2015, 16, 219-222. Kennan, A. J.* "Charting a New Course in Coiled Coils" Nat. Chem. Biol., 2011, 7, 859-860. PDF Diss, M. L.; Kennan, A. J.* "Heterotrimeric Coiled Coils with Core Residue Urea Side Chains" 2008, J. Org. Chem, A.S.A.P. Article [Albert I. Meyers Memorial Issue]. PDF Diss, M. L.; Kennan, A. J.* "Simultaneous Directed Assembly of Three Distinct Heterodimeric Coiled Coils" Org. Lett., 2008, 10, 3797-3800. PDF Diss, M. L.; Kennan, A. J.* "Orthogonal Recognition in Dimeric Coiled Coils via Buried Polar Group Modulation" J. Am. Chem. Soc., 2008, 130, 1321-1327. PDF Ryan, S. J.; Kennan, A. J.* "Variable Stability Heterodimeric Coiled-Coils from Manipulation of Electrostatic Interface Residue Chain Length" J. Am. Chem. Soc., 2007, 129, 10255-10260. PDF Diss, M. L.; Kennan, A. J.* "Facile production of mono-substituted urea side chains in solid phase peptide synthesis" Biopolymers, 2007, 86, 276-281. PDF Ryan, S. J.; Zhang, Y; Kennan, A. J.* "Convenient Access to Glutamic Acid Side Chain Homologs Compatible with Solid Phase Peptide Synthesis" Org. Lett., 2005, 7, 4765-4767. PDF Schnarr, N. A.; Kennan, A. J.* "pH Switchable Strand Orientation in Peptide Assemblies" Org. Lett., 2005, 7, 395-398. PDF Travisano, P.; Kennan, A. J.* "Tuning Stability of Coiled-Coil Heterotrimers by Selection of Steric Matching Partners" Org. Lett., 2004, 6, 4219-4222. PDF Schnarr, N. A.; Kennan, A. J.* "Strand Orientation by Steric Matching: A Designed Antiparallel Coiled-Coil Trimer" J. Am. Chem. Soc., 2004, 126, 14447-14451. PDF Schnarr, N. A.; Kennan, A. J.* "Coiled-Coil Surface Presentation: An Efficient HIV gp41 Binding Interface Mimic," J. Am. Chem. Soc., 2004, 126, 10260-10261. PDF Schnarr, N. A.; Kennan, A. J.* "Sequential and Specific Exchange of Multiple Coiled-coil Components," J. Am. Chem. Soc., 2003, 125, 13046-13051. PDF Schnarr, N. A.; Kennan, A. J.* "pH Triggered Strand Exchange in Coiled-Coil Heterotrimers," J. Am. Chem. Soc., 2003, 125, 6364-6365. PDF Pal Bais, H.; Walker, T. S.; Kennan, A. J.; Stermitz, F. R.; Vivanco, J. M.* "Structure-dependent phytotoxicity of catechins and other flavonoids" J. Ag. Food Chem., 2003, 51, 897-901. PDF Schnarr, N. A.; Kennan, A. J.* "Specific Control of Peptide Self-Assembly with Combined Hydrophobic and Hydrophilic Interfaces" J. Am. Chem. Soc., 2003, 125, 667-671. PDF Schnarr, N. A.; Kennan, A. J.* "Peptide Tic-Tac-Toe: Heterotrimeric Coiled-Coil Specifity from Steric Matching of Multiple Hydrophobic Sidechains" J. Am. Chem. Soc., 2002, 124, 9779-9783. PDF Schnarr, N. A.; Kennan, A. J.* "Coiled-Coil Formation Governed by Unnatural Hydrophobic Core Sidechains" J. Am. Chem. Soc., 2001, 123, 11081-11082. PDF Zhang, Y.; Kennan, A. J.* "Efficient Introduction of Protected Guanidines in BOC Solid Phase Peptide Synthesis" Org. Lett., 2001, 3, 2341-2344. PDF Kennan, A. J.; Haridas, V.; Severin, K.; Lee, D. H.; Ghadiri, M. R.* "A de Novo Designed Peptide Ligase: A Mechanistic Investigation" J. Am. Chem. Soc., 2001, 123, 1797-1803. PDF Severin, K.; Lee, D. H.; Kennan, A. J.; Ghadiri, M. R.* "A Synthetic Peptide Ligase" Nature, 1997, 389, 706-709. PDF Kennan, A. J.; Whitlock, H. W. Jr.* "Host Catalyzed Isoxazole Ring Opening — A Rationally Designed Artificial Enzyme" J. Am. Chem. Soc., 1996, 118, 3027-3028. PDF