蔡进 - 东南大学 - 化学化工学院

研究领域

1、基于分子模拟的靶向小分子抑制剂的抗肿瘤活性研究 2、中枢神经系统、心血管系统药物的设计合成与活性评价 3、新型磷脂材料与纳米药物传输系统研究 4、药物中间体的合成及工艺研究

近期论文

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Zhou, B.;Ji, M.; Cai, J.* Design,synthesis and biological evaluation of bitopicarylpiperazine-hexahydro-pyrazinoquinolines as preferential dopamine D3receptor ligands. Bioorganic Chemistry 2018, 77, 125-135. Zhou, B.; Hong, K.H.;Ji, M.; Cai, J.* Design,synthesis, and biological evaluation of structurally constrained hybridanalogues containing ropinirole moiety as a novel class of potent and selectivedopamine D3 receptor ligands. ChemicalBiology & Drug Design 2018, 92,1597-1609. Guo, M.;Hong, K.H.; Lv, Y.; Ding, Y.; Li, C.; Xu, H.; Qi, W.; Chen, J.; Ji, M.; Cai, J.* A novel and efficient routefor synthesis of Taladegib. Journal OfChemical Research2017, 41,112-115. Zhang, Z.; Zhou, G.; Chen, B.; Cai, J.*; Chen, J.; Wu, X.; Qi, W.; Ji,M. Novel yolk-shell structured silica nanosphere with a movable silica-coatedgold core. Journal of Sol-Gel Science andTechnology 2016, 77, 516-520. Zong, X.; Cai,J.*; Chen, J.; Wang, P.; Zhou, G.; Chen, B.; Li, W.; Ji, M. Design andsynthesis of imidazole N–H substituted amide prodrugs asinhibitors of hepatitis C virus replication. Bioorganic &Medicinal Chemistry Letters2015,25, 3147-3150. Cai, J.;Wei, H.; Hong, K. H.; Wu, X.; Cao, M.; Zong, X.; Li, L.; Sun, C.; Chen, J.; Ji,M. Discovery and preliminary evaluation of 2-aminobenzamideand hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potenthistone deacetylase inhibitors. EuropeanJournal Of Medicinal Chemistry2015,96, 1-13. Cai, J.;Wei, H.; Hong, K.H.; Wu, X.; Zong, X.; Cao, M.; Wang, P.; Li, L.; Sun, C.;Chen, B.; Zhou, G.; Chen, J.; Ji, M. Discovery, bioactivity anddocking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potenthistone deacetylase inhibitors and antitumor agents. Bioorganic& Medicinal Chemistry2015,23, 3457-3471. Cai, J.;Liu, L.; Hong, K. H.; Wang, P.; Li, L.; Cao, M.; Sun, C.; Wu, X.; Zong, X.;Chen, J.; Ji, M. Discovery of phenoxybutanoic acid derivatives aspotent endothelin antagonists with antihypertensive activity. Bioorganic & Medicinal Chemistry2015, 23, 657-667. Cai, J.;Li, Y.; Chen, J.; Wang, P.; Ji, M. Novel and convenient synthesis of 5-benzoyl-1,4-naphthoquinone and its derivatives. Research On Chemical Intermediates2015, 41, 1-9. Cai, J.;Li, L.; Hong, K. H.; Wu, X.; Chen, J.; Wang, P.; Cao, M.; Zong, X.; Ji, M.Discovery of 4-aminoquinazoline-urea derivatives as Aurorakinase inhibitors with antiproliferative activity. Bioorganic& Medicinal Chemistry2014,22, 5813-5823. Cai, J.;Chen, J.; Cao, M.; Wang, P.; Feng, C.; Ji, M. Design, synthesis, and biologicalevaluation of benzofuran derivatives as ET receptorantagonists. Medicinal Chemistry Research2013, 22, 5472-5480. Cai, J.;Liu, L.; Chen, J.; Cao, M.; Ji, M. Design, Synthesis, and Bioactivity ofPyrazole Acid Derivatives as Endothelin Receptor Antagonists. Medicinal Chemistry 2013, 9, 1113-1122. Cai, J.;Sun, M.; Wu, X.; Chen, J.; Wang, P.; Zong, X.; Ji, M. Design and synthesis ofnovel 4-benzothiazole amino quinazolines Dasatinibderivatives as potential anti-tumor agents. European JournalOf Medicinal Chemistry2013,63, 702-712. Cai, J.;Duan, Y.; Yu, J.; Chen, J.; Chao, M.; Ji, M. Bone-targeting glycol and NSAIDSester prodrugs of rhein: Synthesis, hydroxyapatiteaffinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. European Journal Of Medicinal Chemistry 2012, 55,409-419. Cai, J.;Zhang, S.; Zheng, M.; Wu, X.; Chen, J.; Ji, M. Design, synthesis, and in vitro antiproliferative activity of novel Dasatinibderivatives. Bioorganic & MedicinalChemistry Letters 2012, 22, 806-810. Cai, J.;Zhou, W.; Chen, J. Q.; Sun,M.; Ji, M. Synthesis and Crystal Structure of Benzoyloxymethyl(4 alpha,8beta,13 beta)-13-methyl-16-oxo-17-norkauran-18-carbonate Ester. Journal Of Chemical Crystallography2009, 39, 108-111.