个人简介
本科毕业于山东大学医学院,后师从河北医科大学王永利教授和张海林教授,分别获得硕士和博士学位,并于2014年赴英国利兹大学Nikita Gamper教授实验室进行博士后研究。
研究领域
离子通道的生理功能与调节,及其在疼痛、脑缺血、癫痫等神经系统疾病及肿瘤细胞增殖、迁移中的作用及作用机制研究。主要涉及电生理学、成像学、分子生物学和细胞生物学等实验技术。
近期论文
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1. Gao H, Boillat A, Huang D, Liang C, Peers C, Gamper N.Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate.Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6410-E6419. doi: 10.1073/pnas.1620598114. Epub 2017 Jul 17.
2. Gao H, Chen X, Du X, Guan B, Liu Y, Zhang H. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium. 2011 Dec;50(6):559-68.
3. Ge Y, Wang Y, Chen P, Wang Y, Hou C, Wu Y, Zhang M, Li L, Huo C, Shi Q, Gao H *. Polyhydroxytriterpenoids and Phenolic Constituents from Forsythia suspensa (Thunb.) Vahl Leaves. J Agric Food Chem. 2016 Jan 13;64(1):125-31.
4. Du X, Gao H, Jaffe D, Zhang H, Gamper N. M-type K+ channels in peripheral nociceptive pathways. Br J Pharmacol. 2017 Aug 11. doi: 10.1111/bph.13978. [Epub ahead of print]
5. Huang D, Huang S, Gao H, Liu Y, Qi J, Chen P, Wang C, Scragg JL, Vakurov A, Peers C, Du X, Zhang H, Gamper N. Redox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P. Antioxid Redox Signal. 2016 Aug 10;25(5):233-51.
6. Dun J, Chen X, Gao H, Zhang Y, Zhang H, Zhang Y. Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis. Exp Biol Med (Maywood). 2015 Mar 2.
7. Zhao Z, Cui W, Zhang H, Gao H, Li X, Wang Y, Hu H, Li B.Pre-treatment of a single high-dose of atorvastatin provided cardioprotection in different ischaemia/reperfusion models via activating mitochondrial KATP channel. Eur J Pharmacol. 2015 Mar 15;751:89-98.