张凡 - 河北医科大学

个人简介

主要教育经历 2003.09--2007.07 河北医科大学药物制剂专业，获学士学位 2007.09--2010.07 河北医科大学药理学专业，获硕士学位 2010.09--2013.07 河北医科大学药理学专业，获博士学位工作经历 2013.09--2015.09 河北医科大学生物化学与分子生物学教研室，讲师 2015.10--至今河北医科大学生物化学与分子生物学教研室，副教授 2018.06--2018.12 北京大学医学部进修

研究领域

离子通道功能调控在神经精神类疾病（如疼痛、癫痫、抑郁症等）中作用及作用机制，以离子通道为靶点的天然活性产物筛选、作用机制研究以及成药性评价

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Fan Zhang, Yiying Wang, Yu Liu, Hao Han, Dandan Zhang, Xizhenzi Fan, Xiaona Du, Nikita Gamper, Hailin Zhang. Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF-induced pain. The Journal of Neuroscience, 2019. (IF 6.07) 2. Fan Zhang, Yani Liu, Feng Tang, Bo Liang, Huanming Chen, Hailin Zhang, Kewei Wang. Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for anti-epilepsy. The FASEB Journal, 2019. (IF 5.59) 3. Fan Zhang, Sylvain Gigout, Yu Liu, Yiying Wang, Han Hao, Noel J. Buckley, Hailin Zhang, Ian C. Wood, Nikita Gamper. Repressor element 1-silencing transcription factor drives the development of chronic pain states. Pain, 2019. (IF 6.03) 4. Fan Zhang, Yi Mi, Jinlong Qi, Junwei Li, Man Si, Bingcai Guan, Xiaona Guan, Hailong An, Hailin Zhang. Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol, 168, 1030-1042, 2013. (IF 6.8) 5. Fan Zhang, Yani Liu, Dandan Zhang, Xizhenzi Fan, Decheng Shao, Han Li. Suppression of KCNQ/M potassium channel in dorsal root ganglia neurons contributes to the development of osteoarthritic pain. Pharmacology 2019. （IF 1.67） 6. Fan Zhang, Yanxin Cheng, Hong Li, Qingzhong Jia, Hailin Zhang, Senming Zhao. Inhibition of Kv7/M channel currents by the local anesthetic chloroprocaine. Pharmacology, 2015, 96, 124-130. （IF 1.67） 7. Jinlong Qi, Fan Zhang＃(Co-first author), Yi Mi, Yan Fu, Wen Xu, Diqun Zhang, Yibing Wu, Xiaona Du, Qingzhong Jia, Kewei Wang, Hailin Zhang. Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin -7(4H)-ones as novel Kv7/KCNQ potassium channel activators. European Journal of Medicinal Chemistry, 2011, 46(3), 934-943. ( IF:3.3) 8. Rong Chen, Fan Zhang, Li Song, Yanan Shu, Yanling Lin, Lihua Dong, Xi Nie, Dandan Zhang, Peng Chen, Mei Han. Transcriptome profiling reveals that the SM22α-regulated molecular pathways contribute to vascular pathology. J Mol Cell Cardiol. 2014 Jul;72:263-72. （IF 5.1） 9. Yanan Shu, Fan Zhang, Wei Bi, Lihua Dong, Suibing Miao, Lili Zhao, Hong Wang, Mei Han. SM22α inhibits vascular inflammation via stabilization of IκBα in vascular smooth muscle cells. J Mol Cell Cardiol，2015, 7(84):191-9.（IF 4.65） 10. Lili Zhao, Fan Zhang, Peng Chen, Xiaoli Xie, Yongqing Dou, Yanan Shu, Mei Han. Insulin-independent GLUT4 translocation in proliferative vascular smooth muscle cells involves SM22α. J Mol Med, 2016.（IF 4.9）