个人简介
1980-1990 南京大学化学系，先后获得理学学士、硕士、博士学位
1992-1993 英国谢菲尔德大学开展博士后研究
1995-1996 奥地利维也纳工业大学进行客座研究
1990-2007 南京大学化学化工学院工作，曾担任化学化工学院副院长和配位 化学国家重点实验室副主任，1998年晋升为教授。
2008-迄今 东南大学化学化工学院工作，现担任东南大学药物研究中心主任，江苏省生物药物高技术研究重点实验室主任。
现为国家科技重大专项“新药创制”项目评审专家、国家新药审评中心咨询专家、江苏省化学化工学会理事、江苏省创新药物研究院技术委员会委员、江苏省高新技术与产品审评专家、江苏省科技支撑项目和高技术项目审评专家。曾任中国化学会第25届理事。
长期从事药物化学和配位化学方面的基础研究以及药物开发等方面的研发工作。
近期论文
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Novel CK2 specific Pt(II) compound reverses cisplatin-mediated resistance by inhibiting cancer cell stemness and suppressing DNA damage repair in NSCLC treatments Yuanjiang Wang#, Xinyi Wang#, Gang Xu, Shaohua Gou* J. Med.Chem., 2021, 64(7), 4163-4178. Doi:10.1021/acs.jmedchem.1c00079
Discovery of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine derivatives as highly selective CK2 inhibitors with potent cancer cell stemness inhibition Yuanjiang Wang, Zhaodan Lv, Feihong Chen, XingWang, Shaohua Gou* J. Med. Chem., 2021,64(8), 5082-5098. DOI: 10.1021/acs.jmedchem.1c00131
Discoveryof 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol derivatives as glutathione transferase inhibitors with favorable selectivity and tolerated toxicity Qingqing Liu#, Zhikun Liu#, Wuyang Hua, ShaohuaGou* J. Med. Chem., 2021, 64(3), 1701-1702. DOI: 10.1021/acs.jmedchem.0c02048
Conjugatesderived from lapatinib derivatives with cancer cell stemness inhibitors effectively reversed drug resistance in triple- negative breast cancer. Yuanjiang Wang, Zhaodan Lv, Feihong Chen, Xing Wang,Shaohua Gou* J. Med. Chem., 2021, 64(17), 12877-12892.DOI: 10.1021/acs.jmedchem. 1c01013
Blood-brain barrier permeable and NO-releasing multifunctional nanoparticles for Alzheimer’s diseasetreatment: Targeting NO/cGMP/CREB signaling pathways. Zhikun Liua#, Qingqing Liu#,Bin Zhang, Qiao Liu, Lei Fang*, Shaohua Gou* J. Med. Chem., 2021,64(18), 13853-13872.
ROS-Responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenylboronate linker Zhikun Liu#, Bin Zhang#, Shengjin Xia, Lei Fang *, Shaohua Gou * Eur. J. Med. Chem., 2021, 212, 112997. doi: 10.1016/j.ejmech.2020.112997
Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potentia lEGFR/CAIX dual inhibitors Bin Zhang#, Zhikun Liu#, Shengjin Xia, Qingqing Liu, Shaohua Gou * Eur. J. Med. Chem., 2021, 216, 113300.
An Iridium(III) complex bearing a donor-acceptor-donor type ligand for NIR-triggered dual phototherapy. Jian Zhao, Kaiwen Yan, Gang Xu, Qiang Zhao,Chenjie Xu*, Shaohua Gou* Adv. Func. Materials, 2021, 31(11), 2008325.
A light-controlled multi-step drug release nanosystem targeting tumor hypoxia for synergistic cancer therapy. Bin Zhang#, Zichen Xu#, Wen Zhou, Zhikun Liu, Jian Zhao*, Shaohua Gou* Chem. Sci., 2021, 12, 11810–11820. DOI: 10.1039/D1SC01888D.
The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma Qingqing Liu#, Shixian Hua#, XinyiWang, Feihong Chen*, Shaohua Gou* Cancer Immunology Immunotherapy, 21, 70, 497-508. DOI: 10.1007/s00262-020- 02697-3
Breakdown of chemo-immune resistance by a TDO2-targeted Pt(IV) prodrug via attenuating endogenous Kyn-AhR-AQP4 metabolic circuity and TLS-promoted genomic instability Feihong Chen, Gang Xu, Wenyuan Tian, Shaohua Gou* Biochem. Pharmacology, 2021, doi: 10.1016/j.bcp.2021.114785
Platinum-based modification of styrylbenzylsulfonesas multifunctional antitumor agents: Targeting the RAS-RAF pathway, enhancing antitumor activity and overcoming multidrug resistance Zhikun Liu#, Meng Wang#, Hengshan Wang, Lei Fang*, Shaohua Gou* J. Med. Chem., 2020,63, 186-204. DOI: 10.1021/acs.jmedchem.9b01223
Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib- derived platinum(IV) complexes and overcome cisplatin resistance Zhikun Liu,# Meng Wang,# Hengshan Wang, Lei Fang*, Shaohua Gou* Eur. J. Med. Chem., 2020, 194, 12269.
Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3 -dioxygenase Shixian Hua, Feihong Chen, Xinyi Wang, Shaohua Gou* Eur. J. Med. Chem., 2020, 189, 112041
Iridium (III) complexes derived polymeric micelles with low dark toxicity and strong NIR excitation for phototherapy and chemotherapy Jian Zhao, Xinzhong Zhang, Lei Fang*, Chuanzhu Gao, Chenjie Xu*, Shaohua Gou* Small, 2020, 16(14), 2000363.
Bifunctional ruthenium(ii) polypyridyl complexes of curcumin as potential anticancer agents Shuang Li#, Gang Xu#, Yuhua Zhu, Jian Zhao*, Shaohua Gou* Dalton Trans., 2020, 49(27), 9454-9463.
Enhancing photodynamic therapy efficacy of upconversion-based nanoparticles conjugated with a long-lived triplet excited state iridium(III)-naphthalimide complex: toward highly enhanced hypoxia-inducible factor-1 Jian Zhao, Shuchen Sun, Xiaoyan Li, Wenjing Zhang,* Shaohua Gou* ACS Appl. Bio Mater. 2020, 3, 252−262. DOI: 10.1021/acsabm.9b00774
Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3- dioxygenase Shixian Hua, Feihong Chen, Shaohua Gou* Eur. J. Med. Chem., 2020, 187,
Design of a tris-heteroleptic Ru(II) complex with red-light excitation and remarkably improved photobiological activity Shuang Li, Jian Zhao*, Xinyi Wang, Gang Xu, Shaohua Gou*, Qiang Zhao*Inorg. Chem., 2020, 59(15), 11193-11204. DOI: 10.1021/acs.inorgchem.0c01860
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