个人简介
2007年11月作为访问学者赴美国学习与学术交流，2009年6月至2012年10月，美国怀俄明大学研究助理，2014年8月至2018年8月，美国怀俄明大学高级研究助理，助教。
主要荣誉奖项
2017: 国家优秀自费留学生奖，中国驻美大使馆区优秀留学生代表并致辞
2017: 美国怀俄明大学会议资助与奖励
2016-2017: 美国国立卫生研究院 (NIH) 生物医学科学会议资助与奖励
2016: 美国怀俄明大学健康学院会议资助与奖励
2015: 美国怀俄明大学健康科学学院科学研究奖
2015-2018: 美国国立卫生研究院 (NIH) 生物医学科学研究资助与奖励
研究领域
1. 代谢性心肌病和心力衰竭的分子机制及治疗靶标的研究
2. 糖尿病综合征的预后和治疗方案的研究
3. 脂肪肝和肝癌的发生机制和靶向治疗
4. 干细胞在肿瘤和心血管疾病中的研究与应用
5. 溶酶体组织蛋白酶在肿瘤和心血管疾病发生与发展中的作用机制
6. 细胞代谢、自噬、表观遗传和翻译后修饰和在心血管疾病、糖尿病和肿瘤发生中的病理生理学意义和作用机制
近期论文
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1. Guo R, Wang Q, Nair R, Barnes S, Smith D, Dai B, Robinson T, Nair S: Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double blind clinical investigation. Functional Foods in Health and Disease 2018; 8(11): 508-519.
2.Guo R, Hua Y, Ren J, Bornfeldt K, Nair S: Cardiomyocyte-Specific Disruption of Cathepsin K Protects Against Doxorubicin-Induced Cardiotoxicity. Cell death & disease. 2018, 9: 692.
3.Guo R, Nair S, Zhang Y, Ren J. Adiponectin Deficiency Rescues High Fat Diet-Induced Hepatic Injury, Apoptosis and Autophagy Loss Despite Persistent Steatosis. International Journal of Obesity. 2017, 41(9):1403-1412.
4.Guo R, Nair S. Role of MicroRNA in Diabetic Cardiomyopathy: from Mechanism to Intervention. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017, 1863(8):2070-2077.
5. Guo R, Hua Y, Rogers, O, Ren J, Nair S. Cathepsin K knockout preserves cardiac function in diabetic mice. Scientific Report. Aug. 2017, 7(1):8703.
6. Guo R, Rogers O, Nair S. Targeting Apelinergic System in Cardiometabolic Disease. Current drug targets. 2017;18(15):1785-1791.
7. Guo R, Nair S, Ren J. Role of the Cathepsin K/Calcineurin/NFATs Axis in the Pathogenesis and Management of Diabetic Cardiomyopathy. Cardiology Plus. 2016, 1(3).
8. Guo R, Xu X, Babcock SA, Zhang Y, Ren J: Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy. J Hepatol. 2015, 62(3):647-656.
9. Guo R, Zhang Y, Turdi S, Ren J：Adiponectin Knockout Accentuates High Fat Diet-Induced Obesity and Cardiac Dysfunction: Role of Autophagy. Biochim Biophys Acta. 2013, 1832(8):1136-1148.
10. Jiang S*, Guo R*, Zhang Y, Zuo Y, Ren J: Heavy Metal Scavenger Metallothionein Mitigates Deep Hypothermia-Induced Myocardial Contractile Anomalies: Role of Autophagy. Am J Physiol Endocrinol Metab. 2013, 304(1):e74-86.
11. Guo R, Hu N, Kandadi M, Ren J: Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine Hearts. Autophagy. 2012, 8(4):593-608.
12. Guo R, Ren J: Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation. Cardiovasc Res. 2012, 94(3):480-491.
13. Guo R, Scott GI, Ren J: Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice. PLoS One. 2010, 5(6):e11268.
14. Guo R, Ren J: Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway. PLoS One. 2010, 5(1):e8757.
15. Guo R, Ren J: Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health. 2010, 7(4):1285-1301.
16. Guo R, Ma H, Gao F, Zhong L, Ren J: Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. J Mol Cell Cardiol. 2009, 47(2):228-237.
17. Guo R, Zhong L, Ren J: Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clin Exp Pharmacol Physiol. 2009, 36(5-6):463-468.
18. Wang Q, Guo R, Nair S, Smith D, Bisha B, Nair A, Nair R, Downs B, Kushner S, Bagchi M: Safety and Efficacy of N-SORB?, a Proprietary KD120 MEC Metabolically Activated Enzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study. Journal of the American College of Nutrition. 2019, DOI: 10.1080/07315724.2019.1586591.
19. Ma H, Guo R, Yu L, Zhang Y, Ren J: Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J. 2011, 32(8):1025-1038.
20. Ge W, Guo R, Ren J: AMP-dependent kinase and autophagy are involved in aldehyde dehydrogenase 2-offered protection against cardiac toxicity of ethanol. Free Radic Biol Med. 2011, 51(9):1736-1748.
学术兼职
美国心脏学会会员，美国糖尿病学会会员，中国细胞生物学学会会员，临床与实验药理及生理杂志＂Clinical & Experimental Pharmacology &Physiology”（CEPP）和酗酒：临床与实验研究杂志Alcoholism: Clinical and Experimental Research（ACER）等评审委员
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