个人简介

Ph.D., 2005, Stanford University B.S., 1998, California Institute of Technology

研究领域

Organic and Organometallic Chemistry

New Approaches to Hydride Manipulation We are developing new catalysts and conditions to manipulate hydrides such as various C-H and other X-H bonds. Particularly, we're interested in coordinatively directed hydride abstraction and new reactions for complex molecule synthesis that feature C-H activation. It's like a "carrot and stick" approach, in which a Lewis acid directing group directs a target substrate to a reactive metal center. To achieve these goals, we will employ strategies of catalyst design, thus exploring novel organometallic and coordination chemistry, and target-oriented new organic reaction development. Chemical Probes for Biology and Medicine Simultaneously and synergistically with our organometallic work, we are devising conceptually novel chemical tools for research and clinical use. Along these lines, we are currently developing the first ultrasound-activated MRI contrast agent.

近期论文

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Williams, T. J., Wu, X., Dawsey, A. C., Siriwardena-Mahanama, B. N., Allen, M. J. (2014). A (Fluoroalkyl)Guanidine Modulates the Relaxivity of a Phosphonate-Containing T1-Shortening Contrast Agent. J. Fluorine Chem.. Vol. 168, pp. 177-183. DOI: 10.1016/j.jfluchem.2014.09.018. Pennington-Boggio, M. K., Conley, B. L., Richmond, M. G., Williams, T. J. (2014). Synthesis, Structure, and Conformational Dynamics of Rhodium and Iridium Complexes of Dimethylbis(2-pyridyl)borate. Polyhedron. Vol. 35, pp. 24-31. DOI: 10.1016/j.poly.2014.05.042. Boutemy, A., Filho, O. R., Adams, J. D., Williams, T. J. (2014). Adenostoma fasciculatum, California Chamise, Chemistry and Use in Skin Conditions. Integr. Med. Int.. Vol. 1, pp. 25-31. DOI: 10.1159/000362630. Krylova, V. A., Djurovich, P. I., Conley, B. L., Haiges, R., Whited, M., Williams, T. J., Thompson, M. E. (2014). Control of Emission Colour with N-Heterocyclic Carbene (NHC) Ligands in Phosphorescent Three-Coordinate Cu(I) Complexes. Chem. Commun.. Vol. 50, pp. 7176-7179. DOI: 10.1039/C4CC02037E. Celaje, J. A., Pennington-Boggio, M. K., Flaig, R. W., Williams, T. J. (2014). Synthesis and Characterization of Dimethyldi(2-pyridyl)borate Nickel(II) Complexes: A Unimolecular Square Planar to Square Planar Rotation Around Nickel(II). Organometallics. Vol. 33, pp. 2019–2026. DOI: 10.1021/om500173j. Lu, Z., Williams, T. J. (2014). A Dual Site Catalyst for Mild, Selective Nitrile Reduction. Chem. Commun.. Vol. 50, pp. 5391-5393. DOI: 10.1039/C3CC47384H. Li, V., Ghang, Y., Hooley, R. J., Williams, T. J. (2014). Non-Covalent Self Assembly Controls the Relaxivity of Bound Gd Complexes. Chem. Commun.. Vol. 50, pp. 1375-1377. DOI: 10.1039/C3CC48389D. Li, V., Chang, A. Y., Williams, T. J. (2013). A Noncovalent, Fluoroalkyl Coating Monomer for Phosphonate-Covered Nanoparticles. Tetrahedron. pp. 7741-7745. DOI:10.1016/j.tet.2013.05. Dawsey, A. C., Hathaway, K. L., Kim, S., Williams, T. J. (2013). Introductory Chemistry: A Molar Relaxivity Experiment in the High School Classroom. J. Chem. Educ.. Vol. 90, pp. 922-925. DOI: 10.1021/ed3006902. Fontaine, P., Wong, V., Williams, T. J., Garcia, C., Adams, J. D. (2013). Chemical Composition and Antinociceptive Activity of California Sagebrush (Artemisia Californica). Journal of Pharmacognosy and Phytotherapy. Vol. 5 (1), pp. 1-11. DOI 10.5897/JPP11.053. Lu, Z., Malinoski, B., Flores, A. V., Guess, D., Conley, B., Williams, T. J. (2012). Alcohol Dehydrogenation with a Dual Site Ruthenium, Boron Catalyst Occurs at Ruthenium. Catalysts. Vol. 2, pp. 412-421. DOI:10.3390/catal2040412. Lu, Z., Conley, B. L., Williams, T. J. (2012). [Cover] A Three-Stage Mechanistic Model for Ammonia–Borane Dehydrogenation by Shvo’s Catalyst. Organometallics. Vol. 31, pp. 6705–6714. DOI: 10.1021/om300562d. Pennington-Boggio, M. K., Conley, B. L., Williams, T. J. (2012). A Ruthenium-Catalyzed Coupling of Alkynes with 1,3-Diketones. J. Organometallic Chem.. Vol. 716, pp. 6-10. DOI: 10.1016/j.jorganchem.2012.05.017. Dawsey, A. C., Li, V., Hamilton, K. C., Jianmei, W., Williams, T. J. (2012). Copper-Catalyzed Oxidation of Azolines to Azoles. Dalton Trans.. Vol. 41, pp. 7994-8002. DOI: 10.1039/c2dt00025c. Wu, X., Boz, E., Sirkis, A. M., Chang, A. Y., Williams, T. J. (2012). Synthesis and Phosphate Binding of Guanidine-Functionalized Fluorinated Amphiphiles. J. Fluorine Chem.. Vol. 135, pp. 195-218. DOI: 10.1016/j.jfluchem.2011.12.011. Conley, B. L., Guess, D., Williams, T. J. (2011). A Robust, Air-Stable, Reusable Ruthenium Catalyst for Dehydro-genation of Ammonia Borane. J. Am. Chem. Soc.. Vol. 133, pp. 14212-14215. DOI: 10.1021/ja909858a. Williams, T. J., Kershaw, A. D., Li, V., Wu, X. (2011). An Inversion Recovery NMR Experiment. J. Chem. Ed.. Vol. 88 (5), pp. 665-669. DOI: 10.1021/ed1006822. Conley, B. L., Williams, T. J. (2011). Dual Site Catalysts for Hydride Manipulation. Comments Inorg. Chem.. (32), pp. 195-218. DOI:10.1080/02603594.2011.642087. Conley, B. L., Williams, T. J. (2010). Dehydrogenation of Ammonia Borane by Shvo’s Catalyst. Chem. Commun.. (46), pp. 4815-4817. DOI: 10.1039/C003157G. Conley, B. L., Williams, T. J. (2010). Thermochemistry and Molecular Structure of a Remarkable Agostic Interaction in a Heterobifunctional Ruthenium-Boron Complex. J. Am. Chem. Soc.. Vol. 132 (6), pp. 1764-1765. DOI: 10.1021/ja909858a.