个人简介

Jay T. Groves received his B.S. degree in Physics and Chemistry from Tufts University, and then went on to complete his Ph.D. in Biophysics with Professors Steven Boxer and Harden McConnell at Stanford University. He then spent a year as a visiting scholar at Academia Sinica in Taipei, Taiwan before becoming the Division Director’s Fellow in the Physical Biosciences Division at Lawrence Berkeley National Laboratory. In 2001 he joined the Chemistry Department at UC Berkeley as an Assistant Professor. He was promoted to Associate Professor in 2007 and Professor in 2010. In 2008 Professor Groves was appointed as a Howard Hughes Medical Institute Investigator. He has received the Burroughs Wellcome Career Award in the Biomedical Sciences (2000), the Searle Scholars Award (2002), the MIT TR100 (2003), the Beckman Young Investigator Award (2004), and the NSF CAREER Award (2005). He has served as an Associate Editor of the Annual Reviews of Physical Chemistry since 2006.

研究领域

Physical chemistry in living systems

Physical chemistry in living systems Professor Groves is primarily interested in role of spatial organization in biochemical reaction systems. Living cells are not at all well-mixed reaction chambers. Rather, the molecular processes of life occur in elaborate spatial patterns. This interplay between spatial organization and the chemical reactions themselves in living systems adds a fascinating new dimension to chemistry that is rarely encountered outside of biology. Specific research in Professor Groves’ laboratory focuses on how spatial organization influences signal transduction processes at the cell membrane. The research methods combine techniques in optical microscopy and spectroscopy with materials fabrication methods and cell biology. This integrated approach enables the direct observation and physical manipulation of living reaction systems, down to the single molecule level. The conceptual approach is rooted in physics and physical chemistry, with the overarching goal of developing a quantitative and mechanistic understanding biochemical processes in living systems.

近期论文

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Biophys. J. 2016, in press: “Sustained α-catenin conformational activation at E-cadherin junctions in the absence of mechanical force”, Kabir H Biswas*, Kevin L Hartman, Ronen Zaidel-Bar*, Jay T. Groves*. Nano Lett. 2016, in press: “Graphene-templated supported lipid membrane nanochannels”, Wan Li, Jean K. Chung, Young Kwang Lee, Jay T. Groves*. Nat. Struct. Molec. Biol. 2016, in press: “One-way membrane trafficking of SOS in receptor-triggered Ras activation”, Sune M. Christensen, Hsiung-Lin Tu, Jesse Jun, Steven Alvarez, Meredith Triplet, Jeffrey S. Iwig, Kamlesh Yadav, Dafna Bar-Sagi, Jeroen P. Roose*, and Jay T. Groves*. Langmuir 2016, in press: “A microbead supported membrane-based fluorescence imaging assay reveals intermembrane receptor−ligand complex dimension with nanometer precision”, Kabir H. Biswas* and Jay T. Groves*. Proc. Natl. Acad. Sci. USA. 2016, in press: “Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in the recruitment dynamics of the Ras activator SOS”, William Y. C. Huang, Qingrong Yan, Wan-Chen Lin, Jean K. Chung, Scott D. Hansen, Sune M. Christensen, Hsiung-Lin Tua, John Kuriyan, and Jay T. Groves*. Nanoscale. 2016, in press: “Size-dependent, stochastic nature of lipid exchange between nano-vesicles and model membranes”, Seyed R. Tabaei, Jurriaan J. J. Gillissen, Setareh Vafaei, Jay T. Groves, and Nam-Joon Cho*. Nano Letters. 2016, 16, 2890-2895: "Monitoring the waiting time sequence of single Ras GTPase activation events using liposome functionalized zero-mode waveguides". Sune M. Christensen, Meredith G. Triplet, Christopher Rhodes, Jeffrey S. Iwig, Hsiung-Lin Tu, Dimitrios Stamou, and Jay T. Groves*. J. Am. Chem. Soc. 2016, Jan 26: "Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation". Jean K. Chung, Young Kwang Lee, Hiu Yue Monatrice Lam, and Jay T. Groves. J. Phys. Chem B 2016, Jan 15: "Dynamic Organization of Myristoylated Src in the Live Cell Plasma Membrane", Adam W. Smith*, Hector H. Huang, Nicholas F. Endres, Christopher Rhodes, and Jay T. Groves*. Biophys. J. 2016, 110, 176-187: "Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide", Joshua M. Hanson, Douglas L. Gettel, Seyed R. Tabaei, Joshua Jackman, Min Chul Kim, Darryl Y. Sasaki, Jay T. Groves, Bo Liedberg, Nam-Joon Cho, and Atul N. Parikh*. Mol. Biol. Cell 2015, Nov 5; 26(22), 4033-4045: "Diffusion of GPI-linked proteins is influenced by the activity of dynamic cortical actin", Suvrajit Saha, Il-Hyung Lee, Anirban Polley, Jay T Groves, Madan Rao, Satyajit Mayor. Proc. Natl. Acad. Sci USA 2015, Dec 29; 112(52), 15892-15897: "Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly", Il-Hyung Lee, Hiroyuki Kai, Lars-Anders Carlson, Jay T. Groves, and James H. Hurley. Proc. Natl. Acad. Sci USA 2015, Sep 1;112(35):10932-7: "E-cadherin junction formation involves an active kinetic nucleation process", Kabir H. Biswas, Kevin L. Hartman, Cheng-Han Yu, Oliver J. Harrison, Hang Song, Adam W. Smith, William Y.C. Huang, Wan-Chen Lin, Zhenhuan Guo, Anup Padmanabhan, Sergey M. Troyanovsky, Michael L. Dustin, Lawrence Shapiro, Barry Honig, Ronen Zaidel-Bar, and Jay T. Groves. eLife 2015, Mar 6;4: "Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner", Alan R. Lowe, Jeffery H. Tang, Jaime Yassif, Michael Graf, William Y.C. Huang, Jay T. Groves, Karsten Weis, and Jan T Liphart. J Phys Chem B 2015, Mar 26;119(12):4450-9: "Live cell plasma membranes do not exhibit a miscibility phase transition over a wide range of temperatures", II-Hyung Lee, Suvrajit Saha, Anirpan Polley, Hector Huang, Satyajit Mayor, Madan Rao, and Jay T. Groves. Science 2014, 345, 50-54: "Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics", Lars Iversen1, Hsiung-Lin Tu1, Wan-Chen Lin, Sune M. Christensen, Steven M. Abel, Jeff Iwig, Hung-Jen Wu, Jodi Gureasko, Christopher Rhodes, Rebecca S. Petit, Scott D. Hansen, Peter Thill, Cheng-Han Yu, Dimitrios Stamou, Arup K. Chakraborty, John Kuriyan, and Jay T. Groves. Biophysical Journal 2014, 106, 2196-2205: "Spatial Organization of EphA2 at the Cell-Cell Interface Modulates Trans-Endocytosis of EphrinA1", Adrienne C. Greene1, Samuel J. Lord1, Aiwei Tian, Christopher Rhodes, Hiroyuki Kai, and Jay T. Groves. Nano Lett. 2014, 14, 2293-2298: "Size-based chromatography of signaling clusters in a living cell membrane", Niña G. Caculitan1, Hiroyuki Kai1, Eulanca Y. Liu1, Nicole Fay, Yan Yu, Theobald Lohmüller, Geoff P. O’Donoghue, and Jay T. Groves. Proc. Natl. Acad. Sci USA 2014, 111, 2996-3001: "H-Ras forms dimers on membrane surfaces via a protein-protein interface", Wan-Chen Lin1, Lars Iversen1, Hsiung-Lin Tu, Christopher Rhodes, Sune M. Christensen, Jeffrey S. Iwig, Scott D. Hansen, William Y. C. Huang, and Jay T. Groves eLife 2014, 3:e01610: "Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity" Margaret M. Stratton1, Il-Hyung Lee1, Moitrayee Bhattacharyya, Sune M. Christensen, Luke H. Chao, Howard Schulman, Jay T. Groves, and John Kuriyan. Biophys. J. 2013, 105, L11: "Ratiometric Imaging of the T-Cell Actin Cytoskeleton Reveals the Nature of Receptor-Induced Cytoskeletal Enrichment", Alexander A. Smoligovets, Adam W. Smith, and Jay T. Groves eLife 2013, 2, e00778: "Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells", Geoff P. O’Donoghue1, Rafal M. Pielak1, Alexander A. Smoligovets, Jenny J. Lin, and Jay T. Groves Nano Lett. 2013, 13, 3059-3064: "Nanoscale Obstacle Arrays Frustrate Transport of EphA2 – Ephrin-A1 Clusters in Cancer Cell Lines", Theobald Lohmüller1, Qian Xu1, and Jay T. Groves. J. Cell Sci., 2013, 126, 1049-1058: "Modulation of T cell signaling by the actin cytoskeleton.", Yan Yu, Alexander A. Smoligovets, and Jay T. Groves. J. Am. Chem. Soc., 2013, 135, 5012‐5016: "DNA-mediated assembly of protein heterodimers on membrane surfaces.", Michael P. Coyle, Qian Xu, Samantha Chiang, Matthew B. Francis, Jay T. Groves.