个人简介

B.S., 1991, Peking University, Beijing, China Ph.D., 1999, Columbia University, New York, USA

研究领域

Physical Chemistry /Biochemistry 

Research in the Qin group focuses on understanding the structure/function relationship on nucleic acids. We are utilizing a unique biophysical tool, called site-directed spin labeling (SDSL), for studying nucleic acids. At USC, we have developed new SDSL methodologies driven by specific questions related to DNA and RNA, and these expanded SDSL tools have provided information where other methods have failed. The SDSL method, in combination of other biochemical and biophysical approaches, are being utilized to investigate specific DNA and RNA molecules that function in fundamental biological processes. These studies are aimed at revealing detailed information regarding the conformations of the molecules, as well as unveiling the links between structure, dynamics and function. The information will aid in understanding basic biological processes, deciphering causes of human diseases, and developing novel nano-scale devices.

近期论文

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Zheng, X.-H., Cao, Q., Ding, Y.-L., Zhong, Y.-F., Mu, G.,Qin, P.Z., Ji, L.-N. and Mao, Z.-W.* (2015) "Platinum(II) clovers targeting G-quadruplexes and their anticancer activities." Dalton Trans,44, 50–53 Ding, Y., Nguyen, P., Tangprasertchai, N.S., Reyes, C.V., Zhang, X. and Qin, P.Z.* (2015), "Nucleic acid structure and dynamics: perspectives from site-directed spin labeling" Electron Paramagnetic Resonance, 24, 122–147 Ding, Y., Zhang, X., Tham, K.W. and Qin, P.Z.* (2014) "Experimental mapping of DNA duplex shape enabled by global lineshape analyses of a nucleotide-independent nitroxide probe." Nucl. Acids Res., 42, e140 Xu, C.-X., Shen, Y., Hu, Q., Zheng, Y.-X., Cao, Q., Qin, P.Z., Zhao, Y., Ji, L.-N. and Mao, Z.-W. (2014) "Stabilization of Human Telomeric G-Quadruplex and Inhibition of Telomerase Activity by Propeller-Shaped Trinuclear Pt(II) Complexes." Chemistry – An Asian Journal, 9, 2519-2526 Zhang, X., Dantas Machado, A.C., Ding, Y., Chen, Y., Lu, Y., Duan, Y., Tham, K.W., Chen, L., Rohs, R.* and Qin, P.Z.* (2014) "Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling" Nucl. Acids Res., 42, 2789-2797 Nguyen, P., Shi, X., Sigurdsson, S.T., Herschlag, D. and Qin, P.Z.* (2013) "A Single-Stranded Junction Modulates Nanosecond Motional Ordering of the Substrate Recognition Duplex of a Group I Ribozyme" ChemBioChem, 14, 1720-1723 Chen, Y., Zhang, X., Dantas Machado, A.C., Ding, Y., Chen, Z., Qin, P.Z., Rohs, R. and Chen, L. (2013) "Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion" Nucl. Acids Res., 41, 8368-8376 Zhang, Xiaojun, Qin, Peter Z,* (2013) "Studying RNA Folding Using Site-Directed Spin Labeling." In Russell, R. (ed.), Biophysics of RNA folding, 3, 69-87 Zhang, Xiaojun, Tung, Chang-Shung, Sowa, Glenna Z., Hatmal, Ma'mon M., Haworth, Ian S., Qin, Peter Z., (2012) "Global structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling" J. Am. Chem. Soc., 134, 2644–2652 Anna M. Popova, Ma’mon M. Hatmal, Maria Frushicheva, Eric A. Price, Peter Z. Qin,* Ian S. Haworth,* (2012) "Nitroxide Sensing of a DNA Microenvironment: Mechanistic Insights from EPR Spectroscopy and Molecular Dynamics Simulations" J. Phys. Chem. B, 116, 6387?6396 Phuong Nguyen, Peter Z. Qin, (2011) "RNA dynamics: perspectives from spin labels." WIREs: RNA, 3, 62-72 Zhang, Xiaojun, Lee, Sang Won, Zhao, Liang, Xia, Tianbing, Qin, Peter Z. , (2010) "Conformational distributions at the N-peptide/boxB RNA interface studied using site-directed spin labeling." RNA, 16, 2474-2483 Popova, Anna M., Qin, Peter Z., (2010) "A nucleotide-independent nitroxide probe reports on site-specific stereomeric environment in DNA." Biophysical Journal, 99, 2180-2189 Zhang, Xiaojun, Cekan, Pavol, Sigurdsson, Snorri Th., Qin, Peter Z., (2009) "Studying RNA using site-directed spin-labeling and continuous-wave electron paramagnetic resonance spectroscopy." Method Enzymol., 469, 303-328 Popova, Anna M., Kálai, Tamás, Hideg, Kálmán, Qin, Peter Z., (2009) "Site-Specific DNA Structural and Dynamic Features Revealed by Nucleotide-Independent Nitroxide Probes" Biochemistry, 48, 8540-8550 Grant, Gian Paola G., Boyd, Nathan, Herschlag, Daniel, Qin, Peter Z., (2009) "Motions of the Substrate Recognition Duplex in a Group I Intron Assessed by Site-Directed Spin Labeling" J. Am. Chem. Soc., 131, 3136-3137 Sowa, Glenna Z., Qin, Peter Z., (2008) "Site-directed spin labeling studies on nucleic acid structure and dynamics." Prog. Nucleic Acids Res. Mol. Biol., 82, 147-197 Grant, Gian Paola G., Popova, Anna, Qin, Peter Z., (2008) "Diastereomer characterizations of nitroxide-labeled nucleic acids" Biochem. Biophys. Res. Commun., 371, 451-455 Fang, Yun, Shu, Dan, Xiao, Feng, Guo, Peixuan, Qin, Peter Z., (2008) "Modular assembly of chimeric phi29 packaging RNAs that support DNA packaging" Biochem. Biophys. Res. Comm., 372, 589-594 Qin, Peter Z, Haworth, Ian S, Cai, Qi, Kusnetzow, Ana K, Grant, Gian Paola G, Price, Eric A, Sowa, Glenna Z, Popova, Anna, Herreros, Bruno, He, Honghang, (2007) "Measuring nanometer distances in nucleic acids using a sequence-independent nitroxide probe" Nat. Protocols, 2, 2354-2365 Price, Eric A., Sutch, Brian T., Cai, Qi , Qin, Peter Z., Haworth, Ian S., (2007) "Computation of nitroxide-nitroxide distances for spin-labeled DNA duplexes." Biopolymers, 87, 40-50