王大勇 - 海南大学 - 生命科学与药学院

个人简介

教育背景 2000-09--2003-07 沈阳药科大学药理学专业博士 1997-09--2000-07 黑龙江中医药大学药理学专业硕士 1990-09--1995-07 沈阳药科大学英语药学专业（五年制）学士工作简历： 2013-04--今海南大学生物化学与分子生物学教授 2012-05--2013-04美国伊利诺依大学农业、消费者及环境科学学院动物科学系 Research Specialist 2010-03--2012-05美国伊利诺依大学分子及细胞生物学院 Research Scientist 2007-07--2010-02 美国伊利诺依大学分子及细胞生物学院 Postdoctoral Research Associate 2007-04--2007-06日本名古屋大学医学部 COE研究员 2004-10--2007-03 日本（原）公定书协会驻名古屋大学附属医院药剂部Research Resident 2002-04--2004-09 日本名古屋大学大学院神经精神药理学系外国人研究员 1995-08-2000-08 （原）哈尔滨市医药工业研究所（现）哈药集团生物工程有限公司新药研发项目负责人

近期论文

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Jinli Pei, Shuangshuang Wei, Yechun Pei, Hao Wu, Dayong Wang*. Role of dietary gluten in development of celiac disease and type I diabetes: management beyond gluten-free diet. Current Medicinal Chemistry. 2019 Apr 9. doi: 10.2174/0929867326666190409120716. Shuangshuang Wei, Yechun Pei, Yuerong Wang, Huai Guan, Yonglin Huang, Tian Xing, Rodney W. Johnson, Dayong Wang*. Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2. Biochemie. 2019,158:73-81. Yuan Zhou, Lintao Chen, Xi Zhou, Yechun Pei, Shuangshuang Wei, Anum Mehmood, Yang K. Xiang, Dayong Wang*. Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of Β2 Adrenergic Receptor Gene. Journal of Applied Bioinformatics and Computational Biology. 2018, 7(3):21-34. 陈林涛, 韦双双, 黄永林, 吴昊, 郭子怡, 陈银华*, 王大勇*. 重组人血清白蛋白在紫花苜蓿中的转基因表达. 《热带作物学报》. 2018, 39(4):720-725. Yuerong Wang, Shuangshuang Wei, Lintao Chen, Jinli Pei, Hao Wu, Yechun Pei, Yibo Chen, Dayong Wang*. Transcriptomic analysis of gene expression in mice treated with troxerutin. PLOS ONE. 2017, 12(11): e0188261. Yonglin Huang#, Yechun Pei#, Huai Guan, Shuangshuang Wei, Hao Wu, Yuan Zhou, Jinli Pei, Lintao Chen, Yuerong Wang, Yibo Chen, Qian Han, Daming Wang, Dayong Wang*. Stability and Pharmacological Effects of Gene-Recombinant Wild Type and Mutant Human Adrenocorticotropic Hormone. Pharmaceutical Research. 2017, 34(4):793-799. Dayong Wang, Qin Fu, Yuan Zhou, Qian Shi, Benedict Igwe, Elena V. Wisely, Salvatore Oddo, Yang K. Xiang. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer’s disease models. Journal of Biological Chemistry. 2013, 288(15):10298-10307. Ruijie Liu, Dayong Wang, Qian Shi, Qin Fu, Steven Hizon, Yang K. Xiang. Palmitoylation Regulates Intracellular Trafficking of β2 Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes. 2012,7(8):e42658 Dayong Wang, Eunice Yuen, Yuan Zhou, Yan Zhen, Yang K. Xiang. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. Journal of Biological Chemistry. 2011, 286(36):31852-63. Dayong Wang, Yang K. Xiang. β-adrenergic receptor, amyloid Abeta, and Alzheimer’s disease. Current Topics in Membranes: Advances in Adrenergic Receptor Biology. 2011, 67: 205-229. Dayong Wang, G. Govindaiah, Ruijie Liu, Vania De Arcangelis, Charles Lee Cox, Yang Xiang. Binding of Amyloid β peptide to β2 adrenergic receptor induces PKA dependent AMPA receptor hyperactivity. FASEB Journal. 2010, 24(9):3511-21. Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshima. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The International Journal of Neuropsychopharmacology. 2010, 13(10):1343-54. Hiroko Tsunekawa, Yukihiro Noda, Masayuki Miyazaki, Fumio Yoneda, Toshitaka Nabeshima, Dayong Wang. Effects of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders. Behavioural Brain Research. 2008, 189(1): 107-116. Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Role of N-Methyl-D-aspartate receptors in antidepressant-like effects of σ1 receptor agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA-4503) in olfactory bulbectomized rats. Journal of Pharmacology and Experimental Therapeutics. September, 2007, 322(3): 1305-1314. Dayong Wang#, Yukihiro Noda, Yuan Zhou#, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of combined treatment with risperidone and galantamine on phencyclidine-induced impairment of latent visuospatial learning and memory: role of nAChR activation-dependent increase of dopamine D1 receptor-mediated neurotransmission. Neuropharmacology. September, 2007, 53(3): 379-89. Dayong Wang, Yukihiro Noda, Yuan Zhou, Akihiro Mouri, Hiroyuki Mizoguchi, Atsumi Nitta, Weiduo Chen, Toshitaka Nabeshima. The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems. Neuropsychopharmacology. 2007, 32(6): 1261-1271. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model. Neuropharmacology. 2007, 52(4): 1179-87. Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. Behavioural Brain Research. 2007, 178(2): 262-73.