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Mi J#, Zou Y#, Lin X, Lu J, Liu X, Zhao H, Ye X, Hu H, Jiang B, Han B, Shao C*, Gong Y*. (2017) Dysregulation of miR-194 -CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma. Molecular Oncology 11:305-319
Pei-shan Li, Yu Song, Wen-ying Zan, Li-ping Qin, Shuang Han, Bai-chun Jiang, Hao Dou, Chang-shun Shao and Yao-qin Gong* (2016). Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity. Diabetes 66, 300-313
Zhao, W., Jiang, B., Hu, H., Zhang, S., Lv, S., Yuan, J., Qian, Y., Zou, Y., Li, X., Jiang, H.,Liu F, Shao C*, Gong Y*(2015). Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Human molecular genetics 24, 4686-4697. [Medline]
Yuan, J., Jiang, B*., Zhang, A., Qian, Y., Tan, H., Gao, J., Shao, C., and Gong, Y* (2015). Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. Oncotarget 6, 15209-15221. [Medline]
Yuan J, Han B, Hu H, Qian Y, Liu Z, Wei Z, Liang X, Jiang B, Shao C, Gong Y*(2015). CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists. J Pathol. 235:784-795 [Medline]
Zhao X, Jiang B, Hu H, Mao F, Mi J, Li Z, Liu Q, Shao C*, Gong Y*(2015). Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Hum Mol Genet. 24:853-864 [Medline]
Mao F, Li Z, Zhao B, Lin P, Liu P, Zhai M, Liu Q, Shao C, Sun W*, Gong Y*(2015). Identification and Functional Analysis of a SLC33A1: c.339T>G (p.Ser113Arg) Variant in the Original SPG42 Family. Hum Mutat. 36(2):240-9. [Medline]
Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L, Qian Y, Jiang B, Zou Y, Wang Y, Shao C, Gong Y*(2014). CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 127(21):4679-91. [Medline]
Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z, Hu H, Yang Y, Gao X, Jiang B, Shao C*, Gong Y*(2013). CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol. 200(6):743-56. [Medline]
He F, Lu D, Jiang B, Wang Y, Liu Q, Liu Q, Shao C, Li X*, Gong Y*(2013). X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochim Biophys Acta. 1832(5):595-605. [Medline]
Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, Yuan J, Liu Q, Li X, Zou Y, Shao C, Shang Y, Wang Y*, Gong Y*(2012). CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 22(6):781-95. [Medline]
Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, Guo C, Chen B, Shao C*, Gong Y*(2012). Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One. 7(5):e37070. [Medline]
Li X, Lu D, He F, Zhou H, Liu Q, Wang Y, Shao C, Gong Y*(2011). Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. J Biol Chem. 286(37):32344-54. [Medline]
Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, Gao G, Liu Q, Chen B, Shao C*, Gong Y*(2009). Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem. 284(48):33320-32.
Lin P, Li J, Liu Q, Mao F, Li J, Qiu R, Hu H, Song Y, Yang Y, Gao G, Yan C, Yang W, Shao C, Gong Y*(2008). A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42). Am J Hum Genet. 83(6):752-9.
Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, Wei J, Shao C, Gong Y*(2007). Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet. 80(3):561-6.
Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML; Osteoporosis-Pseudoglioma Syndrome Collaborative Group (2001). LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 107(4):513-23.
Gong Y, Krakow D, Marcelino J, Wilkin D, Chitayat D, Babul-Hirji R, Hudgins L, Cremers CW, Cremers FP, Brunner HG, Reinker K, Rimoin DL, Cohn DH, Goodman FR, Reardon W, Patton M, Francomano CA, Warman ML(1999). Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet. 21(3):302-4.
Gong Y, Chitayat D, Kerr B, Chen T, Babul-Hirji R, Pal A, Reiss M, Warman ML(1999). Brachydactyly type B: clinical description, genetic mapping to chromosome 9q, and evidence for a shared ancestral mutation. Am J Hum Genet. 64(2):570-7.
Gong Y, Vikkula M, Boon L, Liu J, Beighton P, Ramesar R, Peltonen L, Somer H, Hirose T, Dallapiccola B, De Paepe A, Swoboda W, Zabel B, Superti-Furga A, Steinmann B, Brunner HG, Jans A, Boles RG, Adkins W, van den Boogaard MJ, Olsen BR, Warman ML(1996). Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet. 59(1):146-51.
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