高维强 - 上海交通大学 - 生物医学工程学院

个人简介

高维强，上海交通大学王宽诚讲席教授，博士生导师。 MED-X研究院院长。 1982年南京大学本科毕业，同年进入中科院就读研究生并入选CUSBEA项目，1983年赴美，1989年获哥伦比亚大学博士，在哥伦比亚大学医学院及洛克菲勒大学完成博士后研究。1993-2010年，历任美国Genentech公司科学家/实验室主任、资深科学家。期间于2003年荣获国家自然科学基金委“海外杰青”。2010年全职回国。担任仁济医院干细胞研究中心主任。长期致力于“干细胞与组织发育修复”和“肿瘤发生发展（包括肿瘤干细胞）”机制研究。近年来聚焦肿瘤干细胞、耐药性、诊断和靶向治疗的探索以及神经损伤修复和内耳毛细胞发育再生的研究。他的研究组于2000年在Nature Neurosci.发表了内耳毛细胞再生的里程碑研究成果； 2008年Nature杂志对他专门做了采访并专页报道了他对“单个干细胞能够在体重建器官”和“肿瘤干细胞理论”的见解。以通讯或第一作者在Nature, Science, Cell, Neuron, Nature Neurosci., Nature Communications, Gastroenterology, PNAS, Cancer Research 等杂志上发表了约70篇文章。获得48项美国专利。并受邀为美国NIH、英国Wellcome Trust、中国自然科学基金会以及40家包括Nature、Nature Medicine、Cancer Cell、Nature Cell Biology、Nature Communications等杂志评审。现正承担科技部国家重点科学研究计划（973）项目和国家自然科学基金重点及面上项目，也是上海市教委肿瘤学重点学科负责人和上海市卫计委重中之重临床肿瘤重点学科负责人。

近期论文

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1.Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ. (2015). Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling. Stem Cell Reports. 2015 Nov 10;5(5):816-28. 2.Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di M, Xia W, Gao W-Q (2015). SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. Oncotarget. 2015 Sep 22;6(28):26494-507. 3.Zhu HH, Zhuang G, Gao W-Q (2015). A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis. J Pathol. 2015 Aug 27. doi: 10.1002/path.4601. [Epub ahead of print] 4.Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao W-Q (2015). CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015 Aug 6. pii: canres.3590.2014. [Epub ahead of print] 5.Qin Y, Gao W-Q (2015).Concise Reviews: Patient-Derived Stem Cell Research for Monogenic Disorders. Stem Cells. 2015 Jul 31. doi: 10.1002/stem.2112. [Epub ahead of print]. 5. Chang YL, Zhou PJ, Wei L, Li W, Ji Z, Fang YX, Gao W-Q (2015). MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway. Oncotarget. 2015 Sep 15;6(27):24017-31. 6. Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R and Gao WQ. Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt. Clinical Cancer Research. 2015 Oct 15;21(20):4676-85. 7. Liu W, Wu H, Chen L, Wen Y, Kong X, Gao WQ. Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res. 2015 Jun;25(6):691-706. (IF=12.41). 8. Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH, Gao WQ. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.184. [Epub ahead of print] 9. Qin Y, Qin J, Zhou C, Li J, Gao WQ. Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer. Cell Cycle. 2015;14(8):1282-90. 10. Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu H, Chu M, Li W, Zhuang G, Gao WQ. TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer. Oncotarget. 2014, 5(19):9498-513. IF=6.627. 11.Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ. TRIM59 Is Up-Regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of P53. Gastroenterology. 2014 Jul 18. pii: S0016-5085(14)00917-2. IF= 16.716. 12.Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ. Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nat Commun. 2014 Aug 28;5:4758. doi: 10.1038/ncomms5758. 13.Li J, Tang YH, Wang YT, Tang RB, Jiang WF, Yang GY and Gao WQ. Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rat. Stem Cell Reports. 2014 Jun 19;3(1):101-14. 14.Li J, Xuan JW, Khatamianfar V, Valiyewa F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ. SKA1 overexpression promotes centriole over duplication, centrosome amplification and prostate tumorigenesis. J Pathol. 2014 Oct;234(2):178-89. 15.Fang, Y and Gao W-Q. Roles of miRNAs during prostate tumorigenesis and tumor progression. Oncogene, 2013 Mar 4. doi: 10.1038/onc.2013.54. 16.Sun Y, Wang BE, Leong KG, Yue P, Li L, Jhunjhunwala S, Chen D, Seo K, Modrusan Z, Gao WQ*, Settleman J*, Johnson L*. Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res. 2012 Jan 15;72(2):527-36. 17.Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R,Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 May 15;474(7351):403-6. 18.Leong KG, Wang BE, Johnson L, Gao WQ. Generation of a prostate from a single adult stem cell. Nature. 2008 Dec 11;456(7223):804-8 （封面文章）. 19.Leow CC, Romero MS, Ross S, Polakis P, Gao WQ. Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Res. 2004 Sep 1;64(17):6050-7. 20.Shou J, Soriano R, Hayward SW, Cunha GR, Williams PM, Gao WQ. Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2830-5. 21.Shou J, Ross S, Koeppen H, de Sauvage FJ, Gao WQ. Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res. 2001 Oct 1;61(19):7291-7. 22.Zheng JL, Shou J, Guillemot F, Kageyama R, Gao WQ. Hes1 is a negative regulator of inner ear hair cell differentiation. Development. 2000 Nov;127(21):4551-60. 23.Zheng JL, Gao WQ. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat Neurosci. 2000 Jun;3(6):580-6. 24.Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science. 2000 Oct 20;290(5491):523-7. 25.Zheng JL, Keller G, Gao WQ. Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery. J Neurosci. 1999 Mar 15;19(6):2161-70. 26.Zheng JL, Helbig C, Gao WQ. Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures. J Neurosci. 1997 Jan 1;17(1):216-26. 27.Zheng JL, Gao WQ. Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker. J Neurosci. 1997 Nov 1;17(21):8270-82. 28.Zheng JL, Stewart RR, Gao WQ. Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity. J Neurosci. 1995 Jul;15(7 Pt 2):5079-87. 29.Gao WQ, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M, Keller G,Hefti F, Phillips HS, Winslow JW. Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Ann Neurol. 1995 Jul;38(1):30-7. 30.Gao WQ, Zheng JL, Karihaloo M. Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation. J Neurosci. 1995 Apr;15(4):2656-67. 31.Gao WQ, Hatten ME. Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum. Development. 1994 May;120(5):1059-70. 32.Gao WQ, Hatten ME. Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex. Science. 1993 Apr 16;260(5106):367-9. 33.Gao WQ, Liu XL, Hatten ME. The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell. 1992 Mar 6;68(5):841-54 （封面文章）. 34.Gao WO, Heintz N, Hatten ME. Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron. 1991 May;6(5):705-15. 35.Gao WQ, Macagno ER. Axon extension and retraction by leech neurons: severing early projections to peripheral targets prevents normal retraction of other projections. Neuron. 1988 Jun;1(4):269-77.