詹启敏 - 北京大学

个人简介

中国协和医科大学研究生毕业(1987)，美国匹兹堡大学医学院终身教职副教授(2002)、分子肿瘤学国家重点实验室主任(2002-)、中国医学科学院副院长(2005-)。现任北京大学医学部主任、北京大学肿瘤医院/研究所教授(2016-)。教育部长江学者，国家杰出青年基金获得者，新世纪百千万人才工程国家级人选，国家自然科学基金委创新群体首席专家，国家973重大基础研究项目首席科学家，享受国务院政府特殊津贴。先后兼任中国微循环学会理事长、中国抗癌协会副理事长、国家生物医药技术战略发展规划专家组组长国家新药创制重大专项生物药专家组组长、《中国生化药物》杂志主编、《科学通报》和《中华肿瘤杂志》副主编、《J Biol Chem》、《Carcinogenesis》、《Cancer Biol and Ther》、《Mol Oncol》等杂志编委。在《Nature》、《Cell》、《Science》、《J Clin Invest》等刊物上发表SCI论文200余篇，SCI他引12000多次。获教育部自然科学一等奖、华夏医学科技一等奖、中华医学科技二等奖和科技部“十一五”国家科技计划执行突出贡献奖。

研究领域

长期致力于肿瘤分子生物学和肿瘤转化医学研究。系统揭示了多个细胞周期监测点关键蛋白的作用和机制及其在细胞癌变和肿瘤诊断与个体化治疗中的作用。近年系统研究了食管鳞癌的遗传突变背景，发现了一批参与细胞周期调控、肿瘤发生及转移相关的lncRNA，并对其功能和作用机制进行了深入研究。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Cheng C, Zhou Y, Li H, Xiong T, Li S, Bi Y, Kong P, Wang F, Cui H, Li Y, Fang X, Yan T, Li Y, Wang J, Yang B, Zhang L, Jia Z, Song B, Hu X, Yang J, Qiu H, Zhang G, Liu J, Xu E, Shi R, Zhang Y, Liu H, He C, Zhao Z, Qian Y, Rong R, Han Z, Zhang Y, Luo W, Wang J, Peng S, Yang X, Li X, Li L, Fang H, Liu X, Ma L, Chen Y, Guo S, Chen X, Xi Y, Li G, Liang J, Yang X, Guo J, Jia J, Li Q, Cheng X, Zhan Q*, Cui Y* (2016) Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma. Am J Hum Genet 98(2): 256-74. 2. Dongdong Zhang, Weimin Zhang, Dan Li, Ming Fu, Runsheng Chen, and Qimin Zhan* (2015) GADD45A Inhibits autophagy by regulating the Interaction between BECN1 and PIK3C3. Autophagy 11(12): 2247-58. 3. Ling Zhang, Yong Zhou, Caixia Cheng, Heyang Cui, Le Cheng, Pengzhou Kong, Jiaqian Wang, Yin Li, Wenliang Chen, Bin Song, Fang Wang, Zhiwu Jia, Lin Li, Yaoping Li, Bin Yang, Jing Liu, Ruyi Shi, Yanghui Bi, Yanyan Zhang, Juan Wang, Zhenxiang Zhao, Xiaoling Hu, Jie Yang, Hongyi Li, Zhibo Gao, Gang Chen, Xuanlin Huang, Xukui Yang, Shengqing Wan, Chao Chen, Bin Li, Yongkai Tan, Longyun Chen, Minghui He, Sha Xie, Xiangchun Li, Xuehan Zhuang, Mengyao Wang, Zhi Xia, Longhai Luo, Jie Ma, Bing Dong, Jiuzhou Zhao, Yongmei Song, Yunwei Ou, Enming Li, Liyan Xu, Jinfen Wang, Yanfeng Xi, Guodong Li, Enwei Xu, Jianfang Liang, Xiaofeng Yang, Jiansheng Guo, Xing Chen, Yanbo Zhang, Qingshan Li, Lixin Liu, Yingrui Li, Xiuqing Zhang, Huanming Yang, Dongxin Lin, Xiaolong Cheng, Yongjun Guo, Jun Wang, Qimin Zhan*, and Yongping Cui* (2015) Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal SquamousCell Carcinoma. Am J Hum Genet 96(4): 597-611. 4. Jie Chen, Tian Lan, Weimin Zhang, Lijia Dong, Nan Kang, Shumin Zhang, Ming Fu, Bing Liu, Kangtai Liu, and Qimin Zhan* (2015) Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. Cancer Res 75(19): 4198-210. 5. J Chen, T Lan, W Zhang, L Dong, N Kang, S Zhang, M Fu, B Liu, K Liu, C Zhang, J Hou and Q Zhan* (2015) Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma. Oncogene 34(40): 5114-27. 6. Li D, Kang N, Ji J, Zhan Q* (2015) BRCA1 regulates transforming growth factor-β (TGF-β1) signaling through Gadd45a by enhancing the protein stability of Smad4. Mol Oncol 9(8):1655-66. 7. Jian Liu, Haijuan Wang, Fei Ma, Dongkui Xu, Yanan Chang, Jinlong Zhang, Jia Wang, Mei Zhao, Chen Lin, Changzhi Huang*, Haili Qian*, Qimin Zhan* (2015) MTA1 regulates higher-order chromatin structure and histone H1-chromatin. Mol Oncol 9(1): 218-35. 8. Dong Y, Zhao Q, Ma X, Ma G, Liu C, Chen Z, Yu L, Liu X, Zhang Y, Shao S, Xiao J, Li J, Zhang W, Fu M, Dong L, Yang X, Guo X, Xue L, Fang F, Zhan Q*, Zhang L* (2015) Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach. Sci Rep 5: 12668. 9. Yongmei Song, Lin Li, Yunwei Ou, Zhibo Gao, Enmin Li, Xiangchun Li, Weimin Zhang, Jiaqian Wang, Liyan Xu, Yong Zhou, Xiaojuan Ma, Lingyan Liu, Zitong Zhao, Xuanlin Huang, Jing Fan, Lijia Dong, Gang Chen, Liying Ma,Jia Yang, Longyun Chen, Minghui He, Miao Li, Xuehan Zhuang, Kai Huang, Kunlong Qiu, Guangliang Yin, Guangwu Guo, Qiang Feng, Peishan Chen, Zhiyong Wu, Jianyi Wu, Ling Ma, Jinyang Zhao, Longhai Luo, Ming Fu, Bainan Xu, Bo Chen, Yingrui Li, Tong Tong, Mingrong Wang, Zhihua Liu, Dongxin Lin, Xiuqing Zhang, Huanming Yang, Jun Wang & Qimin Zhan* (2014) Identification of genomic alterations in oesophageal squamous cell cancer. Nature 509(7498): 91-5. 10. Jianzhong Cao, Yongmei Song, Nan Bi, Jie Shen, Wenyang Liu, Jing Fan, Guogui Sun, Tong Tong, Jie He, Yuankai Shi, Xun Zhang, Ning Lu, Yinghua He, Hongyu Zhang, KelongMa, Xiaoying Luo, Lei Lv, Hui Deng, Jing Cheng, Jingde Zhu, Luhua Wang, and Qimin Zhan* (2013) DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer. Cancer Res 73(11): 3326-35. 11. Xuefeng Liu, Dan Li, Weimin Zhang, Mingzhou Guo and Qimin Zhan* (2012) Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay. EMBO J 31(23): 4415-27. 12. Yulin Chen, Dan Li, Dapeng Wang, Xuefeng Liu, Ning Yin, Yongmei Song, Shih Hsin Lu, Zhenyu Ju, and Qimin Zhan* (2012) Quiescence and Attenuated DNA Damage Response Promote Surivival of Esophageal Cancer Stem Cells. J Cell Biol 12:3643-3652.