个人简介
教育背景
1990-09--1993-06 普度大学 博士
1987-09--1990-06 加州大学河滨分校 硕士
1984-09--1987-06 北京农业大学 学士
工作简历
2010-09~现在, 中国科学院上海植物逆境生物学研究中心, 主任
2010-09~2016-02,普度大学, 杰出教授
2009-07~2011-07,KAUST大学植物逆境基因组中心, 主任
2007-09~2010-06,加州大学河滨分校植物学与植物科学系, 讲座教授
2004-09~2006-06,加州大学河滨分校植物学与植物科学系, 特聘教授, 研究所所长
2000-09~2003-06,亚利桑那大学植物科学系, 教授
1999-09~2000-06,亚利桑那大学植物科学系, 副教授
1996-09~1998-06,亚利桑那大学植物科学系, 助理教授
1995-09~1996-06,奥本大学植物与微生物学系, 助理教授
1993-09~1994-06,洛克菲勒大学, 博士后
教授课程
植物生理与分子生物学
专利成果
( 1 ) 增强植物抗逆性的小分子化合物, 发明, 2016, 第 1 作者, 专利号: CN201610284100.0
( 2 ) 增强植物抗逆性的小分子化合物, 实用新型, 2016, 第 1 作者, 专利号: PCT/CN2016/080790
( 3 ) 高抗逆性的植物生长调节剂及其制法和用途, 发明, 2016, 第 1 作者, 专利号: CN201610325811.8
( 4 ) 增强植物抗逆性的ABA类似物, 发明, 2015, 第 1 作者, 专利号: CN201511004527.2
( 5 ) 植物基因组定点修饰方法, 发明, 2014, 第 1 作者, 专利号: CN201410334460.8
( 6 ) 植物基因组定点修饰方法, 实用新型, 2014, 第 1 作者, 专利号: PCT/CN2014/082144
科研项目
( 1 ) 新型抗除草剂基因的发现和作用抗性改良, 主持, 省级, 2014-04--2016-12
近期论文
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(1) De novo assembly and analysis of the transcriptome of Ocimum americanum var. pilosum under cold stress., BMC Genomics, 2016, 通讯作者
(2) Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling., PLoS Genet, 2016, 通讯作者
(3) ABA receptor PYL9 promotes drought resistance and leaf senescence., Proc Natl Acad Sci U S A., 2016, 通讯作者
(4) Dicer-independent RNA-directed DNA methylation in Arabidopsis., Cell Res, 2016, 通讯作者
(5) Assessing Kinase Activity in Plants with In-Gel Kinase Assays., Methods Mol Biol., 2016, 通讯作者
(6) RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway., New Phytol., 2016, 通讯作者
(7) Epigenetic Modifications and Plant Hormone Action., Mol Plant., 2016, 通讯作者
(8) TALEN-mediated targeted mutagenesis produces a large variety of heritable mutations in rice., Plant Biotechnol J., 2016, 通讯作者
(9) A DNA ligase required for active DNA demethylation and genomic imprinting in Arabidopsis., Cell Res., 2016, 通讯作者
(10) Development of germ-line-specific CRISPR-Cas9 systems to improve the production of heritable gene modifications in Arabidopsis., Plant Biotechnol J., 2015, 通讯作者
(11) MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis., PLoS Genet., 2015, 通讯作者
(12) A multiplex CRISPR/Cas9 platform for fast and efficient editing of multiple genes in Arabidopsis., Plant Cell Rep., 2015, 通讯作者
(13) Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets., Sci Rep., 2015, 通讯作者
(14) Cold responsive gene transcription becomes more complex., Trends Plant Sci., 2015, 通讯作者
(15) An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses., Nat Commun., 2015, 通讯作者
(16) Nitric oxide suppresses the inhibitory effect of abscisic acid on seed germination by S-nitrosylation of SnRK2 proteins., Plant Signal Behav., 2015, 通讯作者
(17) Involvement of Multiple Gene-Silencing Pathways in a Paramutation-like Phenomenon in Arabidopsis., Cell Rep, 2015, 通讯作者
(18) . A DNA ligase required for active DNA demethylation and genomic imprinting in Arabidopsis., Cell Res., 2015, 通讯作者
(19) The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration., Proc Natl Acad Sci U S A., 2015, 通讯作者
(20) The BASL Polarity Protein Controls a MAPK Signaling Feedback Loop in Asymmetric Cell Division., Dev Cell, 2015, 通讯作者
(21) Stomatal guard cells co-opted an ancient ABA-dependent desiccation survival system to regulate stomatal closure., Curr Biol., 2015, 通讯作者
(22) Regulatory link between DNA methylation and active demethylation in Arabidopsis., Proc Natl Acad Sci U S A., 2015, 通讯作者
(23) The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing., Mol Cell, 2015, 通讯作者
(24) Increasing freezing tolerance: kinase regulation of ICE1., Dev Cell, 2015, 通讯作者
(25) HOS1 regulates Argonaute1 by promoting transcription of the microRNA gene MIR168b in Arabidopsis., Plant J., 2015, 通讯作者
(26) Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis., Plant Physiol., 2015, 通讯作者
(27) An AP endonuclease functions in active DNA dimethylation and gene imprinting in arabidopsis., PLoS Genet., 2015, 通讯作者
(28) Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1., Proc Natl Acad Sci U S A., 2015, 通讯作者
(29) Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation., EMBO J., 2015, 通讯作者
(30) Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex., Cell Mol Life Sci., 2015, 通讯作者
(31) The Arabidopsis Vacuolar Sorting Receptor1 is required for osmotic stress-induced abscisic acid biosynthesis., Plant Physiol., 2015, 通讯作者
(32) Swaminathan K, Melcher K. 2014. H2O2 inhibits ABA-signaling protein phosphatase HAB1., PLoS One., 2014, 通讯作者
(33) SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis., Cell Res., 2014, 通讯作者
(34) CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis., Plant Cell, 2014, 通讯作者
(35) Measuring spatial and temporal Ca2+ signals in Arabidopsis plants., J Vis Exp., 2014, 通讯作者
(36) Emerging roles of RNA processing factors in regulating long non-coding RNAs., RNA Biol., 2014, 通讯作者
(37) Identification of ERK1 Direct Substrates using Stable Isotope Labeled Kinase Assay-Linked Phosphoproteomics., Mol Cell Proteomics., 2014, 通讯作者
(38) Regulation of Active DNA Demethylation by an α-Crystallin Domain Protein in Arabidopsis., Mol Cell., 2014, 通讯作者
(39) Protocol: a beginner's guide to the analysis of RNA-directed DNA methylation in plants., Plant Methods., 2014, 通讯作者
(40) Overproduction of stomatal lineage cells in Arabidopsis mutants defective in active DNA demethylation., Nat Commun., 2014, 通讯作者
(41) The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes., Sci Signal, 2014, 通讯作者
(42) Constitutive production of nitric oxide leads to enhanced drought stress resistance and extensive transcriptional reprogramming in Arabidopsis., J Exp Bot, 2014, 通讯作者
(43) Timmis JN. 2014. Transcription of nuclear organellar DNA in a model plant system., Genome Biol Evol., 2014, 通讯作者
(44) The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation., Plant Biotechnol J., 2014, 通讯作者
(45) RNA splicing factors and RNA-directed DNA methylation., Biology (Basel), 2014, 通讯作者
(46) An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis., Mol Cell., 2014, 通讯作者
(47) The Arabidopsis STRESS RESPONSE SUPPRESSOR DEAD-box RNA helicases are nucleolar- and chromocenter-localized proteins that undergo stress-mediated relocalization and are involved in epigenetic gene silencing., Plant J., 2014, 通讯作者
(48) Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis., Proc Natl Acad Sci U S A., 2014, 通讯作者
(49) Sulfate availability affects ABA levels and germination response to ABA and salt stress in Arabidopsis thaliana., Plant J., 2014, 通讯作者
(50) Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns., Proc Natl Acad Sci U S A., 2014, 通讯作者