施一公 - 清华大学 - 生命科学学院

个人简介

1985-1989 清华大学生物科学与技术系，学士 1990-1995 美国约翰霍普金斯大学医学院，分子生物物理学博士 1995 美国约翰霍普金斯大学医学院，博士后 1996-1997　美国纽约斯隆•凯特林癌症研究中心，博士后 1998-2001 美国普林斯顿大学分子生物学系，助理教授 2001-2003 美国普林斯顿大学分子生物学系，（终身）副教授 2003-2007 美国普林斯顿大学分子生物学系，（终身）教授 2007-2008 美国普林斯顿大学分子生物学系，Warner-Lambert/Parke-Davis教授 2008-至今清华大学生命科学学院，教授、博导

研究领域

主要运用结构生物学、生物化学和生物物理的手段研究RNA剪接、细胞凋亡等细胞内生物大分子机器的结构与功能，以及γ-分泌酶介导的阿尔茨海默症的分子机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Fenghua Yang, Tong Bian, Xiechao Zhan, Zhe Chen, Zhihan Xing, Nicolas A Larsen, Xiaofeng Zhang, Yigong Shi. Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly. Nature Communications. 14(1):897. doi: 10.1038/s41467-023-36489-x. Epub 2023 Feb 17. Gaoxingyu Huang, Chao Zeng, Yigong Shi. Structure of the nuclear pore complex goes atomic. Structure of the nuclear pore complex goes atomic. Current Opinion in Structural Biology. 78:102523. doi: 10.1016/j.sbi.2022.102523. Epub 2023 Jan 13. Jiayao Zhou, Yumeng Wang, Gaoxingyu Huang, Min Yang, Yumin Zhu, Chen Jin, Dan Jing, Kai Ji, Yigong Shi (2023). LilrB3 is a putative cell surface receptor of APOE4. Cell Research. 33(2):116-130. doi: 10.1038/s41422-022-00759-y. Epub 2023 Jan 2. Xuefei Guo, Yumeng Wang, Jiayao Zhou, Chen Jin, Jiaoni Wang, Bojun Jia, Dan Jing, Chuangye Yan, Jianlin Lei, Rui Zhou, Yigong Shi. Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nature Communications. 13(1):6299. doi: 10.1038/s41467-022-33817-5. Epub 2022 Oct 22. Qiang Su, Mengying Chen, Yan Shi, Xiaofeng Zhang, Gaoxingyu Huang, Bangdong Huang, Dongwei Liu, Zhangsuo Liu, Yigong Shi (2022). Cryo-EM structure of the human IgM B cell receptor. Science. 377(6608): 875-880.doi: 10.1126/science.abo3923. Epub 2022 Aug 18. Xiechao Zhan, Yichen Lu, Xiaofeng Zhang, Chuangye Yan, Yigong Shi (2022). Mechanism of exon ligation by human spliceosome. Molecular Cell. 82(15): 2769-2778.doi: 10.1016/j.molcel.2022.05.021. Epub 2022 Jun 14. Xuechen Zhu, Gaoxingyu Huang, Chao Zeng, Xiechao Zhan, Ke Liang, Qikui Xu, Yanyu Zhao, Pan Wang, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi (2022). Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex. Science. 376(6598): eabl8280.doi: 10.1126/science.abl8280. Epub 2022 Jun 10. Gaoxingyu Huang, Xiechao Zhan, Chao Zeng, Ke Liang, Xuechen Zhu, Yanyu Zhao, Pan Wang, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, and Yigong Shi (2022). Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex. Cell Research. 32(5): 451-460. doi: 10.1038/s41422-022-00633-x. Epub 2022 Mar 18. Gaoxingyu Huang, Xiechao Zhan , Chao Zeng, Xuechen Zhu, Ke Liang, Yanyu Zhao, Pan Wang, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan and Yigong Shi (2022). Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex. Cell Research. 32(4):349-358. doi: 10.1038/s41422-021-00610-w. Epub 2022 Feb 17. Chen Jin, Jiaoni Wang, Yumeng Wang, Bojun Jia, Xuefei Guo, Guanghui Yang, Peng Xu, Paul Greengard, Rui Zhou and Yigong Shi. (2022). Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation. Proc Natl Acad Sci U S A. 119(12), e2122292119. doi: 10.1073/pnas.2122292119. Epub 2022 Mar 17. Lingyu Liu, Hu Deng, Xiaping Tang, Yingxian Lu, Jiayao Zhou, Xiaofei Wang, Yanyu Zhao, Bing Huang, Yigong Shi. (2021). Specific electromagnetic radiation in the wireless signal range increases wakefulness in mice. Proc Natl Acad Sci U S A. 118(31), e2105838118. doi:10.1073/pnas.2105838118. July 30, 2021. Qiang Su, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, Yigong Shi (2021). Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nature Communications. 12(1):4871. doi: 10.1038/s41467-021-25216-z. 11 August 2021. Rui Bai, Ruixue Wan, Lin Wang, Kui Xu, Qiangfang Zhang, Jianlin Lei, and Yigong Shi (2021). Structure of the activated human minor spliceosome. Science. Eabg0879. doi: 10.1126/science.abg0879. Epub 2021 Jan 28. Guanghui Yang, Rui Zhou, Xuefeng Guo, Chuangye Yan, and Yigong Shi (2020). Structural basis of γ-secretase inhibition and modulation by small molecule drugs. Cell. 184(2):521-533. doi: 10.1016/j.cell.2020.11.049. Epub 2020 Dec 28. Rui Bai, Ruixue Wan, Chuangye Yan, Qi Jia, Jianlin Lei, and Yigong Shi (2020). Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science. eabe8863. doi: 10.1126/science.abe8863. Epub 2020 Nov 26. Hangping Yao, Yutong Song, Yong Chen, Nanping Wu, Jialu Xu, Chujie Sun, Jiaxing Zhang, Tianhao Weng, Zheyuan Zhang, Zhigang Wu, Linfang Cheng, Danrong Shi, Xiangyun Lu, Jianlin Lei, Max Crispin, Yigong Shi, Lanjuan Li, Sai Li (2020). Molecular Architecture of the SARS-CoV-2 Virus. Cell. 183(3):730-738.e13. Epub 2020 Sep 6. Elena A Minina, ……Yigong Shi, …… Peter V Bozhkov (2020). Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. Mol. Cell. 77(5):927-929. 2020 Mar 5. Gaoxingyu Huang, Yanqing Zhang, Xuechen Zhu, Chao Zeng, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, and Yigong Shi (2020). Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research. 30(6):532-540. Epub 2020 May 6. Yanqing Zhang, Sai Li, Chao Zeng, Gaoxingyu Huang, Xuechen Zhu, Qifan Wang, Kunpeng Wang, Qiang Zhou, Chuangye Yan, Wusheng Zhang, Guangwen Yang, Minhao Liu, Qinghua Tao, Jianlin Lei, and Yigong Shi (2020). Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex. Cell Research. 30(6):520-531. Epub 2020 May 4. Ruixue Wan, Rui Bai, Xiechao Zhan, and Yigong Shi (2019). How Is Precursor Messenger RNA Spliced by the Spliceosome?. Annu Rev Biochem. 89:333-358. Epub 2019 Dec 9. Ruixue Wan, Rui Bai, and Yigong Shi (2019). Molecular choreography of pre-mRNA splicing by the spliceosome. Curr Opin Struct Biol. 59:124-133. Epub 2019 Dec. Rui Zhou, Guanghui Yang, Yigong Shi. Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer’s disease. Current Opinion in Structural Biology. 61:1-8. 10.1016/j.sbi.2019.09.004. Epub 2019 Apr. Chuangye Yan, Ruixue Wang, and Yigong Shi (2019). Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome. Cold Spring Harbor Perspectives in Biology. 11(1). Epub 2019 Jan. Xiaofeng Zhang, Xiechao Zhan, Chuangye Yan, Wenyu Zhang, Dongliang Liu, Jianlin Lei and Yigong Shi (2018). Structures of the human spliceosomes before and after release of the ligated exon. Cell Res. 29(4):274-285. Epub 2019 Feb 6. Ruixue Wan, Rui Bai, Chuangye Yan, Jianlin Lei, and Yigong Shi (2018). Structures of the catalytically activated yeast spliceosome reveal the mechanism of branching. Cell. 177(2):339-351. Epub 2019 Mar 14. Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianling Lei, and Yigong Shi(2019). Recognition of the amyloid precursor protein by human γ-secretase. Science. 363(6428). Epub 2019 Feb 15. Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianling Lei, and Yigong Shi (2019). Structural basis of Notch recognition by human γ-secretase. Nature. 565(7738):192-197. Epub 2018 Dec 31. Shenjie Wu, Wenqi Song, Catherine C. L. Wong, and Yigong Shi (2018). Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein. Proc Natl Acad Sci U S A. 116(1):141-147. Epub 2018 Dec 17. Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, and Yigong Shi (2018). Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res. 28(12):1129-1140. Epub 2018 Oct 12. Chuangye Yan, Ruixue Wang, and Yigong Shi (2019). Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome. Cold Spring Harb Perspect Biol. 11(1). pii: a032409. (commissioned review). Qiang Su, Feizhuo Hu, Xiaofei Ge, Jianlin Lei, Shengqiang Yu, Tingliang Wang, Qiang Zhou, Changlin Mei, and Yigong Shi (2018). Structure of the human PKD1-PKD2 complex. Science. 361(6406):pii: eaat9819. Epub 2018 Aug 9. Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi (2018). Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science. 360(6396):1423-1429. Epub 2018 May 24. Xi Zhang, Qifan Wang, Jianping Wu, Jiawei Wang, Yigong Shi, and Minhao Liu (2018). Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state. Proc Natl Acad Sci U S A. 115(15):3828-3833. Epub 2018 Mar 26. Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei, Yigong Shi (2018). Structure of the human activated spliceosome in three conformational states. Cell Res. 28(3):307-322. Epub 2018 Jan 23. Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, Yigong Shi (2018). Structure of a human catalytic step I spliceosome. Science. 359(6375):537-545. Epub 2018 Jan 4.