冯新华 - 浙江大学 - 生命科学研究院

个人简介

教育经历 1983 武汉大学生物学学士 1986 中国科学院遗传研究所遗传学硕士 1992 美国马里兰大学（University of Maryland-College Park）植物生物学博士 1993-1997 美国加州大学旧金山分校（UCSF）生化/细胞生物学博士后工作经历 1983 武汉大学生物学学士 1986 中国科学院遗传研究所遗传学硕士 1992 美国马里兰大学（University of Maryland-College Park）植物生物学博士 1993-1997 美国加州大学旧金山分校（UCSF）生化/细胞生物学博士后 1997-1999 加州大学旧金山分校组织细胞学系研究助理教授 1999-2003 美国贝勒医学院（BCM）外科学系、分子与细胞生物学系助理教授 2003-2007 美国贝勒医学院分子与细胞生物学系、外科学系副教授（tenured） 2007-至今美国贝勒医学院分子与细胞生物学系、外科学系、分子生理与生物物理学系教授（Tenured, now part-time faculty） 2007-至今 Duncan癌症中心研究员、STaR干细胞与再生医学中心研究员、炎症生物学中心研究员 2008-至今美国德州农工医学中心（Texas A&M Health Science Center）兼职教授（Adjunct Professor） 2009-至今浙江大学生命科学研究院教授、首席研究员、院长学术荣誉 2001 Keck Distinguished Young Scholar 2003 American Cancer Society Research Scholar 2003 Leukemia & Lymphoma Society Scholar 2006 Michael E. DeBakey Excellence in Research, BCM 2007 MCB Excellence in Research, BCM 2012 美国科学促进会（AAAS）Fellow

研究领域

在分子、细胞水平并结合动物模型，探讨信号转导网络、磷酸酶组和蛋白质翻译后修饰在正常组织器官发育、干细胞维持和分化以及癌症发生和转移中的生物功能及其作用机制。

近期论文

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Yu Y, Feng XH. TGF-β signaling in cell fate control and cancer.Curr Opin Cell Biol. 2019 Aug 1;61:56-63. Yuan B, Liu J, Cao J, Yu Y, Zhang H, Wang F, Zhu Y, Xiao M, Liu S, Ye Y, Ma L, Xu D, Xu N, Li Y, Zhao B, Xu P, Jin J, Xu J, Chen X, Shen L, Lin X, Feng XH. PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity. EMBO J. 2019 Jul 15;38(14):e99945. Zhang Q, Xiao M, Gu S, Xu Y, Liu T, Li H, Yu Y, Qin L, Zhu Y, Chen F, Wang Y, Ding C, Wu H, Ji H, Chen Z, Zu Y, Malkoski S, Li Y, Liang T, Ji J, Qin J, Xu P, Zhao B, Shen L, Lin X, Feng XH. ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions. Nat Cell Biol. 2019 Feb;21(2):179-189. Liu J, Zhao M, Yuan B, Gu S, Zheng M, Zou J, Jin J, Liu T, Feng XH. WDR74 functions as a novel coactivator in TGF-β signaling. J Genet Genomics. 2018 Dec 20;45(12):639-650. Gu S, Feng XH. TGF-β signaling in cancer. Acta Biochim Biophys Sin (Shanghai). 2018 Oct 1;50(10):941-949. Liu H, Dai X, Cao X, Yan H, Ji X, Zhang H, Shen S, Si Y, Zhang H, Chen J, Li L, Zhao JC, Yu J, Feng XH, Zhao B. PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression. EMBO Rep. 2018 Jun;19(6). pii: e45180. Zhu C, Ji X, Zhang H, Zhou Q, Cao X, Tang M, Si Y, Yan H, Li L, Liang T, Feng XH, Zhao B. Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway. J Biol Chem. 2018 Jan 26;293(4):1178-1191. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 Apr 2;128(4):1283-1299. Ma X, Chen X, Jin Y, Ge W, Wang W, Kong L, Ji J, Guo X, Huang J, Feng XH, Fu J, Zhu S. Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells. Nat Commun. 2018 Apr 3;9(1):1303. Zhao Y, Liu J, Chen F, Feng XH. C-terminal domain small phosphatase-like 2 promotes epithelial-to-mesenchymal transition via Snail dephosphorylation and stabilization. Open Biol. 2018 Apr;8(4). pii: 170274. Sun S, Liu S, Zhang Z, Zeng W, Sun C, Tao T, Lin X, Feng XH. Phosphatase UBLCP1 controls proteasome assembly. Open Biol. 2017 May;7(5). pii: 170042. Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, Wang L, Xu D, Li Y, Ding C, Xia Z, Li Y, Ye S, Xu P, Zhao B, Qin J, Chen YG, Lin X, Feng XH. Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10113-10118. Si Y, Ji X, Cao X, Dai X, Xu L, Zhao H, Guo X, Yan H, Zhang H, Zhu C, Zhou Q, Tang M, Xia Z, Li L, Cong YS, Ye S, Liang T, Feng XH, Zhao B. Src inhibits the hippo tumor suppressor pathway through tyrosine phosphorylation of lats1. Cancer Res. 2017 Sep 15;77(18):4868-4880. Liu T, Zhao M, Liu J, He Z, Zhang Y, You H, Huang J, Lin X, Feng XH. Tumor suppressor bromodomain-containing protein 7 cooperates with smads to promote transforming growth factor-β responses. Oncogene. 2017 Jan 19;36(3):362-372. Xu P, Lin X, Feng XH. Posttranslational regulation of smads. Cold Spring Harb Perspect Biol. 2016 Dec 1;8(12). pii: a022087. Liu S, Long J, Yuan B, Zheng M, Xiao M, Xu J, Lin X, Feng XH. Sumo modification reverses inhibitory effects of smad nuclear interacting protein-1 in TGF-β responses. J Biol Chem. 2016 Nov 18;291(47):24418-24430. Sun C, Wang G, Wrighton KH, Lin H, Songyang Z, Feng XH, Lin X. Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G. Am J Cancer Res. 2016 Oct 1;6(10):2207-2220. Feng XH, Liang YY, Liang M, Zhai W, Lin X. Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15(Ink4B). Mol Cell. 2016 Apr 7;62(1):152. Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH. PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling. Cell. 2016 Sep 8;166(6):1597. Xiang W, Zhang Q, Lin X, Wu S, Zhou Y, Meng F, Fan Y, Shen T, Xiao M, Xia Z, Zou J, Feng XH, Xu P. PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1. Sci Adv. 2016 Jul 1;2(7):e1501889.

学术兼职

2006-2012 Editorial Board, Journal of Biological Chemistry 2010-2012 Member, Board of Directors, 华人生物科学家协会（CBIS） 2012-2013 Treasurer, 美洲华人生物科学学会（SCBA） 2009-2015 Member, SCBA Council 2008-至今 Associate Editor, BMC Developmental Biology 2010-至今 Editorial Board, Cell Research 2010-至今 Editorial Board, Journal of Genetics and Genomics 2010-至今 Editorial Board, Cell & Bioscience 2012-至今中国蛋白质专业委员会理事 2013-2015 中国细胞生物学学会信号转导分会副会长 2014-至今美国细胞生物学学会（ASCB）国际事务委员会委员 2015-至今中国细胞生物学学会理事、信号转导分会会长 2015-至今中国生命科学学会联合体专家委员会委员 2015-至今 Editorial Board, Cell Discovery