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个人简介

杨亮博士2004年本科毕业于南开大学生物科学专业,2009年在丹麦技术大学获得博士学位,随后在丹麦技术大学和德国汉堡大学从事博士后工作,2012年入职新加坡南洋理工大学生命科学学院做助理教授,并在2018年2月获得终身教职 (Associate Professor with Tenure)和担任生命科学学院助理院长,同时兼任新加坡国家级卓越研究中心"新加坡环境生物工程中心(Singapore Centre for Environmental Life Sciences Engineering,简称SCELSE)"公共卫生中心实验室副主任。杨亮于2018年10月入职南方科技大学医学院任教授,是广东省杰出青年基金获得者,深圳市海外引进高层次人才(孔雀计划B类),教育部青年专家,2019 爱思唯尔中国高被引学者(微生物与免疫)。目前在南方科技大学讲授“医学微生物学(本科)”、“医学微生物实验(本科)”和“微生物技术(研究生)”三门核心课程

研究领域

细菌生物被膜(biofilm)形成机理 致病菌的耐药机理 致病菌-宿主相互作用 新型抗生素研发

近期论文

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Allesen-Holm M, Barken KB, Yang L, Klausen M, Webb JS, Kjelleberg S, Molin S, Givskov M, Tolker-Nielsen T (2006). A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. Molecular microbiology 59: 1114-1128 Li Y, Xia H, Bai F, Xu H, Yang L, Yao H, Zhang L, Zhang X, Bai Y, Saris PE, Tolker-Nielsen T, Qiao M (2007). Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa. FEMS microbiology letters 272: 188-195 Qin Z, Ou Y, Yang L, Zhu Y, Tolker-Nielsen T, Molin S, Qu D (2007). Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis. Microbiology 153: 2083-2092 Yang L, Barken KB, Skindersoe ME, Christensen AB, Givskov M, Tolker-Nielsen T (2007). Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa. Microbiology 153: 1318-1328 Barken KB, Pamp SJ, Yang L, Gjermansen M, Bertrand JJ, Klausen M, Givskov M, Whitchurch CB, Engel JN, Tolker-Nielsen T (2008). Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms. Environmental microbiology 10: 2331-2343 Ryan RP, Fouhy Y, Garcia BF, Watt SA, Niehaus K, Yang L, Tolker-Nielsen T, Dow JM (2008). Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa. Molecular microbiology 68: 75-86 Skindersoe ME, Alhede M, Phipps R, Yang L, Jensen PO, Rasmussen TB, Bjarnsholt T, Tolker-Nielsen T, Hoiby N, Givskov M (2008). Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 52: 3648-3663 Qin Z*, Yang L*, Qu D, Molin S, Tolker-Nielsen T (2009). Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis. Microbiology 155: 2148-2156 (* Co-first author) Ryan RP, Lucey J, O'Donovan K, McCarthy Y, Yang L, Tolker-Nielsen T, Dow JM (2009). HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa. Environmental microbiology 11: 1126-1136 Yang L, Nilsson M, Gjermansen M, Givskov M, Tolker-Nielsen T (2009). Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation. Molecular microbiology 74: 1380-1392 Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, Tolker-Nielsen T (2009). Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors. Antimicrobial agents and chemotherapy 53: 2432-2443 Gjermansen M, Nilsson M, Yang L, Tolker-Nielsen T (2010). Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms. Molecular microbiology 75: 815-826 Yang L*, Liu Y, Sternberg C, Molin S (2010). Evaluation of enoyl-acyl carrier protein reductase inhibitors as Pseudomonas aeruginosa quorum-quenching reagents. Molecules 15: 780-792 (* Corresponding author) Harmsen M, Yang L, Pamp SJ, Tolker-Nielsen T (2010). An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal. FEMS immunology and medical microbiology 59: 253-268 Herrmann G, Yang L, Wu H, Song Z, Wang H, Hoiby N, Ulrich M, Molin S, Riethmuller J, Doring G (2010). Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa. The Journal of infectious diseases 202: 1585-1592 Liu Y, Yang L*, Molin S (2010). Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation. Antimicrobial agents and chemotherapy 54: 3960-3963 (* Corresponding author) McCarthy Y, Yang L, Twomey KB, Sass A, Tolker-Nielsen T, Mahenthiralingam E, Dow JM, Ryan RP (2010). A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia. Molecular microbiology 77: 1220-1236 Lujan AM, Macia MD, Yang L, Molin S, Oliver A, Smania AM (2011). Evolution and adaptation in Pseudomonas aeruginosa biofilms driven by mismatch repair system-deficient mutators. PloS one 6: e27842 Rohde H, Qin J, Cui Y, Li D, Loman NJ, Hentschke M, Chen W, Pu F, Peng Y, Li J, Xi F, Li S, Li Y, Zhang Z, Yang X, Zhao M, Wang P, Guan Y, Cen Z, Zhao X, Christner M, Kobbe R, Loos S, Oh J, Yang L, Danchin A, Gao GF, Song Y, Li Y, Yang H, Wang J, Xu J, Pallen MJ, Wang J, Aepfelbacher M, Yang R, Consortium EcOHGAC-S (2011). Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. The New England Journal of Medicine 365: 718-724 Giraud C, Bernard CS, Calderon V, Yang L, Filloux A, Molin S, Fichant G, Bordi C, de Bentzmann S (2011). The PprA-PprB two-component system activates CupE, the first non-archetypal Pseudomonas aeruginosa chaperone-usher pathway system assembling fimbriae. Environmental microbiology 13: 666-683

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