聂磊 - 河北医科大学 - 河北医科大学基础医学院

个人简介

2005年毕业于河北医科大学生化及分子生物学专业，博士学位，之后在耶鲁大学医学院心血管内科系完成博士后培训2010年被耶鲁大学聘为副研究员，专业从事心血管分子生物学研究，成果分别发表在JClinInvest，Circulation等本专业权威学术刊物上。2014年全职回国，现为河北医科大学生物化学与分子生物学研究室教授，博士生导师，基础医学院科研副院长。研究方向：心血管分子生物学，内皮细胞和血管平滑肌细胞功能与心血管疾病的关系。共发表论文40余篇，其中SCI论文20篇，第一作者影响因子最高15.35，总影响因子118分，它引163次。参编著作《血管平滑肌细胞》（科学出版社），《医学分子生物学理论与实验技术》（科学出版社，第三版）资金情况：国家自然科学基金面上项目两项（123万）、河北医科大学引进人才启动资金（30万）、河北省自然科学基金一项（6万)

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.NieLei,GuoX,EsmailzadehL,ZhangJ,AsadiA,CollingeM,LiX,KimJD,WoollsM,JinSW,DubracA,EichmannA,SimonsM,BenderJR,SadeghiMM.TransmembraneproteinESDNpromotesendothelialVEGFsignalingandregulatesangiogenesis.JClinInvest.2013,123(12):5082-5097(第一作者，IF=13.78） 2.NiuH,LiY,LiH,ChiY,ZhuangM,ZhangT,LiuM,NieLei.Matrixmetalloproteinase12modulateshigh-fat-dietinducedglomerularfibrogenesisandinflammationinamousemodelofobesity.SciRep.2016Jan29;6:20171.doi:10.1038/srep20171.（通讯作者，IF=5.578） 3.ZhaoLL,ZhangF,ChenP,XieXL,DouYQ,LinYL,NieLei,LvP,ZhangDD,LiXK,MiaoSB,YinYJ,DongLH,SongY,ShuYN,HanM.Insulin-independentGLUT4translocationinproliferativevascularsmoothmusclecellsinvolvesSM22α.JMolMed,2016Sep8DOI:10.1007/s00109-016-1468-2（影响因子=4.855） 4.ZhaoJ,NiuH,LiA,NieLei.AcetylbritannilactoneModulatesVascularEndothelialGrowthFactorSignalingandRegulatesAngiogenesisinEndothelialCells.PLoSOne.2016Feb10;11(2):e0148968.doi:10.1371/journal.pone.0148968.eCollection2016（通讯作者，IF=3.234） 5.XuanLi,Jae-JoonJung,LeiNie,MahmoudRazavian,JiashengZhang,VarmanSamuel,MehranM.Sadeghi.Aneuropilin-likeprotein,ESDNregulatesinsulinsignalingandsensitivity.AmJPhysiolHeartC,2016May1;310(9):H1184-93,DOI:10.1152/ajpheart.00782.2015(co-firstauthor，SCI，影响因子=3.838) 6. GolestaniR,RazavianM,NieLei,ZhangJ,JungJJ,YeY,deRooM,HilgerinkK,LiuC,RobinsonSP,SadeghiMM.Imagingvesselwallbiologytopredictoutcomeinabdominalaorticaneurysm.CircCardiovascImaging.2014Dec30;8(1) 7. NieLei,RazavianM,ChallaA,ZhangJ,GolestaniR,JungJJ,RobinsonS,SadeghiMM.Lipidloweringandimagingproteaseactivationinatherosclerosis.JNuclCardiol.JNuclCardiol.2014Apr;21(2):319-328(Co-firstauthor，IF=2.942) 8. NiuH,NieLei,LiuM,ChiY,ZhangT,LiY.Benazeprilaffectsintegrin-linkedkinaseandsmoothmuscleα-actinexpressionindiabeticratglomerulusandculturedmesangialcells.BMCNephrol.2014Aug20;15:135(Co-firstauthor，IF=1.69) 9. JungJJ,RazavianM,ChallaA,NieLei,GolestaniR,ZhangJ,YeY,RussellK,RobinsonS,HeistadD,SadeghiM.Multimodalityandmolecularimagingofmatrixmetalloproteinaseactivationincalcificaorticvalvedisease.JNuclMed.2015Apr23.pii:jnumed.114.152355 10. ZhangJ,RazavianM,TavakoliS,NieLei,TellidesG,BackerJM,BackerMV,BenderJR,SadeghiMM.Molecularimagingofvascularendothelialgrowthfactorreceptorsingraftarteriosclerosis.ArteriosclerThrombVascBiol.2012Aug;32(8):1849-55 11. RazavianM,TavakoliS,ZhangJ,NieLei,DobruckiLW,SinusasAJ,AzureM,RobinsonS,SadeghiMM.Atherosclerosisplaqueheterogeneityandresponsetotherapydetectedbyinvivomolecularimagingofmatrixmetalloproteinaseactivation.JNuclMed.2011;52(11):1795-1802. 12. RazavianM,MarfatiaR,Mongue-DinH,TavakoliS,SinusasAJ,ZhangJ,NieLei,SadeghiMM.Integrin-targetedimagingofinflammationinvascularremodeling.ArteriosclerThrombVascBiol.2011,31(12):2820-2826. 13. TavakoliS,RazavianM,ZhangJ,NieLei,MarfatiaR,DobruckiLW,SinusasAJ,RobinsonS,EdwardsDS,SadeghiMM.Matrixmetalloproteinaseactivationpredictsameliorationofremodelingafterdietarymodificationininjuredarteries.Arterioscler.Thromb.Vasc.Biol.2011,31:102-109. 14. RazavianM,ZhangJ,NieLei,TavakoliS,RazavianN,DobruckiLW,SinusasAJ,EdwardsDS,AzureM,SadeghiMM.Molecularimagingofmatrixmetalloproteinaseactivationtopredictmurineaneurysmexpansioninvivo.J.Nucl.Med.2010,51:1107-1115. 15. ZhangJ,SilvaT,YarovinskyT,ManesTD,TavakoliS,NieLei,TellidesG,PoberJS,BenderJR,SadeghiMM.VEGFblockadeinhibitslymphocyterecruitmentandamelioratesimmune-mediatedvascularremodeling.Circ.Res.2010,107:408-417. 16. GuoX,NieLei,EsmailzadehL,ZhangJ,BenderJR,SadeghiMM.Endothelialandsmoothmuscle-derivedneuropilin-likeproteinregulatesplatelet-derivedgrowthfactorsignalinginhumanVSMCsbymodulatingreceptorubiquitination.J.Biol.Chem.2009,284:29376-29382 17. HanM,LiAY,MengF,DongLH,ZhengB,HuHJ,NieLei,WenJK.Synergisticco-operationofsignaltransducerandactivatoroftranscription5Bwithactivatorprotein1inangiotensinII-inducedangiotensinogengeneactivationinvascularsmoothmusclecells.FEBSJ.2009,276(6):1720-1728. 18. ZhangJ,NieLei,RazavianM,AhmedM,DobruckiLW,AsadiA,EdwardsDS,AzureM,SinusasAJ,SadeghiMM.Molecularimagingofactivatedmatrixmetalloproteinasesinvascularremodeling.Circulation.2008,118:1953-1960.