个人简介
受教育经历
2002.9-2008.7,北京大学,医学部基础医学院生物化学与分子生物学系,硕博连读,获理学博士学位
1997.9-2002.7,北京大学,医学部基础医学院,基础医学专业本科,获医学学士学位
研究工作经历
2017.2-至今,湖南师范大学,医学院检验系,副教授
2012.9-2017.2,浙江师范大学,化学与生命科学学院,副教授
2008.7-2012.9,浙江师范大学,化学与生命科学学院,讲师
研究领域
主持或参加科研项目(课题)及人才计划项目情况
1.国家自然科学基金面上项目,81870201,干细胞心肌程序分化中HDAC1、EZH2的阶段特异性效应及其成因,2019.01-2022.12,57万,主持
2.国家自然科学基金面上项目,31470082,发育期心脏感应环境胁迫的Nkx2.5蛋白剪切机制研究,2015.01-2016.12,30万,主持
3.国家自然科学基金青年基金,31101057,心肌程序分化过程中MSK、RSK激酶阶段特异性效应及机制的研究,2012.01-2014.12,25万,主持
近期论文
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1.LiT,HeZ,ZhangX,TianM,JiangK,ChengG,WangY.ThestatusofMAPKcascadescontributestotheinductionandactivationofGata4andNkx2.5duringthestepwiseprocessofcardiacdifferentiation.CellSignal.2019Feb;54:17-26.
2.LiT,ZhangX,JiangK,LiuJ,LiuZ.DuraleffectsofoxidativestressoncardiomyogenesisviaGata4transcriptionandproteinubiquitination.CellDeathDis.2018Feb14;9(2):246.
3.ChenY,HuangQ,ZhouH,WangY,HuX,LiT.InhibitionofcanonicalWNT/β-cateninsignalingisinvolvedinleflunomide(LEF)-mediatedcytotoxiceffectsonrenalcarcinomacells.Oncotarget.2016Aug2;7(31):50401-50416.
4.YuZ,LiT,WangC,DengS,ZhangB,HuoX,ZhangB,WangX,ZhongY,MaX.Gamabufotalintriggersc-MycdegradationviainductionofWWP2inmultiplemyelomacells.Oncotarget.2016Mar29;7(13):15725-37.
5.LiP,SunX,MaZ,LiuY,JinY,GeR,HaoL,MaY,HanS,SunH,ZhangM,LiR,LiT,ShenL.TranscriptionalReactivationofOTX2,RX1andSIX3duringReprogrammingContributestotheGenerationofRPECellsfromHumaniPSCs.INTJBIOLSCI.2016Feb20;12(5):505-17.
6.LiuY,LiP,LiuK,HeQ,HanS,SunX,LiT,ShenL.TimelyinhibitionofNotchsignalingbyDAPTpromotescardiacdifferentiationofmurinepluripotentstemcells.PLOSONE.2014Oct14;9(10):e109588.DOI:10.1371/journal.pone.0109588
7.LiuZ,LiT,JiangK,HuangQ,ChenY,QianF.InductionofChemoresistancebyAll-TransRetinoicAcidviaaNoncanonicalSignalinginMultipleMyelomaCells.PLOSONE.2014Jan9;9(1):e85571DOI:10.1371/journal.pone.0085571
8.LiT,LiuZ,JiangK,RuanQ.Angiopoietin2EnhancesDoxorubinResistanceinHepG2cellsbyUpregulatingSurvivinandRef-1viaMSK1activation.CancerLett.2013,337(2):276-84.
9.LiT,LiuZ,HuX,MaK,ZhouC.InvolvementofERK-RSKcascadeinphenylephrine-inducedphosphorylationofGATA4.BiochimBiophysActa-MolecularCellResearch.2012,1823(2):582-92.
10.HuX,LiT,ZhangC,LiuY,XuM,WangW,JiaZ,MaK,ZhangY,ZhouC.GATA4regulatesANFexpressionsynergisticallywithSp1inacardiachypertrophymodel.JCellMolMed.2011Sep;15(9):1865-77.
11.LiuZ,LiT,LiuY,JiaZ,LiY,ZhangC,ChenP,MaK,AffaraN,ZhouC.WNTsignalingpromotesNkx2.5expressionandearlycardiomyogenesisviadownregulationofHdac1.BiochimBiophysActa-MolecularCellResearch.2009,1793(2):300-11.
12.LiT,LiY,JiaZ,ChenP,MaK,ZhouC.CarboxylterminusofNkx2.5impairsitsinteractionwithp300.JMolBiol.2007,370(5):976-992.