个人简介

教育背景 2015.9-2018.7博士研究生吉林大学基础医学院生物化学与分子生物学（硕博连读） 2013.9-2015.7硕士研究生吉林大学基础医学院生物化学与分子生物学（推免） 2008.9-2013.7本科吉林大学公共卫生学院预防医学

研究领域

研究方向：分子免疫学与微生态方向

科研项目 1. 2019年度河南省重点研发与推广专项（科技攻关），靶向PD-1 mRNA的反义脱氧寡核苷酸的疫苗佐剂效应研究，2019.01- 2020.12，10万元，在研，主持 2. 国家自然科学基金面上项目，31670937，CTLA-4mRNA 3’UTR靶向性寡核苷酸及其疫苗佐剂功能，2017.01- 2020.12，60万元，在研，参加

近期论文

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1.LiX,YangL,ZhaoP,YaoY,LuF,TuL,LiuJ,LiZ,YuY,WangL.AdjuvanticityofaCTLA-43'UTRcomplementaryoligonucleotideforemulsionformulatedrecombinantsubunitandinactivatedvaccines.Vaccine.2017;35:2379-89. 2.LiX,MengX,WangS,LiZ,YangL,TuL,DiaoW,YuC,YuY,YanC,WangL.Virus-likeparticlesofrecombinantPCV2bcarryingFMDV-VP1epitopesinducebothanti-PCVandanti-FMDVantibodyresponses.Appliedmicrobiologyandbiotechnology.2018;102:10541-50. 3.LiX,WangJ,YaoY,YangL,LiZ,YuC,ZhaoP,YuY,WangL.Comparativeefficacyandsafetyofimmunecheckpointinhibitor-relatedtherapiesforadvancedmelanoma:aBayesiannetworkanalysis.Oncotarget.2017;8:83637-49. 4.LiX,GuoS,YangL,HuaL,LiZ,HaoX,YuY,SunW,WangL.Impactofantigens,adjuvantsandstrainsonsexuallydimorphicantibodyresponsetovaccinesinmice.Biologicals:journaloftheInternationalAssociationofBiologicalStandardization.2017;48:47-54. 5.WangJ,LiX,WuX,WangZ,ZhangC,CaoG,ZhangX,PengF,YanT.Roleofimmunecheckpointinhibitor-basedtherapiesformetastaticrenalcellcarcinomainthefirst-linesetting:ABayesiannetworkanalysis.EBioMedicine.2019;47:78-88.（共同一作） 6.WangJ,LiX,WuX,WangZ,ZhangC,CaoG,YanT.ExpressionProfilingofExosomalmiRNAsDerivedfromthePeripheralBloodofKidneyRecipientswithDGFUsingHigh-ThroughputSequencing.BioMedresearchinternational.2019;2019:1759697.（共同一作） 7.YuC,LiX,DiaoW,LiuJ,YaoY,HuaL,YuY,YuY,WangL.AsimplemethodofextractingCapantigenofPCV2bfromemulsifiedvaccinesfortestingitsstabilityandantigenicity.Biologicals:journaloftheInternationalAssociationofBiologicalStandardization.2017;46:114-23. 8.YuC,LiX,LiuJ,DiaoW,ZhangL,XiaoY,WeiH,YuY,YuY,WangL.ReplacingthedecoyepitopeofPCV2bcapsidproteinwithaprotectiveepitopeenhancesefficacyofPCV2bvaccine.Vaccine.2016;34:6358-66. 9.GaoS,LiX,NieS,YangL,TuL,DongB,ZhaoP,WangY,YuY,WangL,HuaS.AnAAAG-RichOligodeoxynucleotideRescuesMicefromBacterialSepticPeritonitisbyInterferingInterferonRegulatoryFactor5.Internationaljournalofmolecularsciences.2017;18. 10.GuoS,LiX,WanM,HuaL,XiaoY,DongB,LiuJ,DiaoW,YuY,WangL.ImpactofFightingonAntibodyResponsetoHepatitisBVirusVaccineinMice.Viralimmunology.2015;28:517-23. 11.XiaoY,LuW,LiX,ZhaoP,YaoY,WangX,WangY,LinZ,YuY,HuaS,WangL.AnoligodeoxynucleotidewithAAAGrepeatssignificantlyattenuatesburn-inducedsystemicinflammatoryresponsesviainhibitinginterferonregulatoryfactor5pathway.Molecularmedicine.2017;23:166-76. 12.XiaoY,ZhaoP,DuJ,LiX,LuW,HaoX,DongB,YuY,WangL.High-levelexpressionandimmunogenicityofporcinecircovirustype2bcapsidproteinwithoutnuclearlocalizationsignalexpressedinHansenulapolymorpha.Biologicals:journaloftheInternationalAssociationofBiologicalStandardization.2018;51:18-24. 13.DongB,WangL,NieS,LiX,XiaoY,YangL,MengX,ZhaoP,CuiC,TuL,LuW,SunW,YuY.Anti-gliomaeffectofintracranialvaccinationwithtumorcelllysateplusflagellininmice.Vaccine.2018;36:8148-57. 14.LiZ,SongY,CuiC,LanY,LiX,LiuY,LuF,ZhangY,YuY,WangL.ALAG3-interferingoligonucleotideactsasanadjuvanttoenhancetheantibodyresponsesinducedbyrecombinantproteinvaccinesandinactivatedinfluenzavirusvaccines.Appliedmicrobiologyandbiotechnology.2019;103:6543-57. 15.YangL,TuL,ZhaoP,WangY,WangS,LuW,WangY,LiX,YuY,HuaS,WangL.Attenuationofinterferonregulatoryfactor7activityinlocalinfectioussitesoftracheaandlungforpreventingthedevelopmentofacutelunginjurycausedbyinfluenzaAvirus.Immunology.2019;157:37-51. 16.HuaL,FangM,DongB,GuoS,CuiC,LiuJ,YaoY,XiaoY,LiX,RenY,MengX,HaoX,ZhaoP,SongY,WangL,YuY.AttributionofNKG2DLtotheinhibitionofearlystageallogeneictumorsinmice.Oncotarget.2016;7:82369-83. 17.YangZ,WangL,YuH,WangR,GouY,ZhangM,KangC,LiuT,LanY,WangX,LiuJ,CooperMA,LiX,YueK,YuY,WangL,KimBYS,JiangW,SunW.MembraneTLR9PositiveNeutrophilMediatedMPLAProtectsAgainstFatalBacterialSepsis.Theranostics.2019;9:6269-83.