个人简介

1969年6月出生，博士，教授，博士生导师。1992年毕业于成都科技大学（现四川大学）化学工程系无机化工专业获工学学士，2000年毕业于重庆大学化学化工学院获物理化学专业硕士学位，2003年毕业于中国人民解放军第三军医大学免疫学专业获医学博士学位。主要从事免疫信息学、基础免疫学及药物设计学等领域的研究。中国免疫协会终身会员，重庆市免疫协会副秘书长、常务理事、免疫信息学专委会主任，重庆市生物医学工程协会理事。重庆市“计算机辅助药物设计与化学生物学”创新团队学术带头人，重庆市十二五重点学科药学一级学科带头人 作为项目负责人先后承担了4项国家自然科学基金项目、1项教育部“新世纪优秀人才支持计划专项基金”以及4项重庆市科委和教委等项目；作为合作单位负责人承担了国家自然科学基金重点项目1项；作为主要研究人员参与完成了包括国家“973计划”项目、国家自然科学基金项目、教育部“春晖计划”等项目15项。

研究领域

计算机辅助疫苗设计与免疫信息学 多肽类药物分子设计与结构修饰 基于重要靶点的药物设计

主要从事免疫信息学、基础免疫学及药物设计学等领域的研究。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]Xingyan Luo, Mao Shu, Yuanqiang Wang, Jin Liu, Wenjuan Yang and Zhihua Lin*.3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking. Molecules, 2012, 17, 2015-2029 [2]Yuanqiang Wang, Yuan Ding, Haixia Wen, Yong Lin,Yong Hu, Ya Zhang, Qingyou Xia and Zhihua Lin*.QSAR Modeling and Design of Cationic Antimicrobial Peptides Based on Structural Properties of Amino Acids. Combinatorial Chemistry & High Throughput Screening, 2012, 15, 347-353. [3]Yuanqing Wang, Xiaoming Cheng, Yong Lin, Haixia Wen, Li Wang, Qingyou Xia, Zhihua Lin*. Quantitative Prediction of TAP and MHC Class I Binding Peptides using QSAR Modeling based on Amino Acid Structural Information. Current Computer-Aided Drug Design, 2012, 8, 50-54. [4]Mao Shu, Xiaoming Cheng, Yunru Zhang,Yuanqiang Wang, Yong Lin, Li Wang, Zhihua Lin*.Predicting the activity of ACE inhibitory peptides with a novel mode of pseudo amino acid composition.Protein & Peptide Letters,2011,18(12):1233-1243. [5]Juan Wang, Xiao-Yu Wang, Mao Shu, Yuan-Qiang Wang, Yong Lin, Li Wang，Xiao-Ming Cheng, Zhi-Hua Lin*.QSAR Study on MHC Class I A alleles based on the novel parameters of amino acids.Protein & Peptide Letters,2011,18:956-963. [6]Jiankun Liu,Yuzhong Duan, Xiaoming Cheng, Xi Chen, Wei Xie, Haixia Long, Zhihua Lin*, Bo Zhu. IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. Biochemical and Biophysical Research Communications. 2011,407(2):348-354. [7]Wang Yuanqiang, Zhang Heng, Lin Yong, Zhao Qi, Liu Hui, Zhang zhan, Lin Zhihua*. 3D-QSAR Studies on Caspase-mediated Apoptosis Activity of Phenolic analogues，Journal of Molecular Modelling, 2011，17：1-8. [8]Xiaoyu Wang, Juan Wang, Yong Lin , Yuan Ding ,Yuanqiang Wang, Xiaoming Cheng, Zhihua Lin*. QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors. Journal of Molecular Modelling, 2011,17：1599-1606. [9]Xie Rong-Kai, Long Hai-Xia, Cheng Xiao-Ming, Wang Yuan-Qiang, Lin Yong, Yang Ying, Zhu Bo, Lin Zhi-Hua*. Quantitative sequence-kinetics relationship in antigen-antiboby interaction kinetics based on a set of descriptors. Chemical Biology & Drug Design, 2010，76：345-349. [10] Zhi-hua Lin*, Hai-xia Long, Zhu Bo, Yuan-qiang Wang, Yu-zhang Wu. New descriptors of amino acids and their application to peptide QSAR study.Peptides,2008,29:1798-1805.