个人简介
博士，副教授，硕士生导师。西南交通大学雏鹰学者，第十四批四川省卫生健康委学术技术带头人后备人选。长期从事靶向自噬关键靶标的抗肿瘤、抗帕金森小分子药物设计合成及作用机制研究和药物重定位研究及其新靶点和新机制的发现。近年来，以第一或通讯作者（含共同一作）在Chem Sci, J Med Chem, Acta Pharm Sin B, Eur J Med Chem，Theranostics，Cell Death & Diseae，Cancer Letters等国内外著名期刊发表论文31篇（其中IF>5分共23篇），包括化学综合一区期刊《Chem Sci》1篇，药学TOP期刊《Acta Pharm Sin B》3篇，药物化学TOP期刊《J Med Chem》7篇，《Eur J Med Chem》5篇。主持国家自然科学基金面上项目和青年基金项目，中国博士后特别资助，中国博士后科学基金面上项目，四川省科技厅科技创新项目等多个项目。另外，还受邀参与编写自噬相关的英文学术专著2本。申请中国发明专利8项，已授权6项。担任J Med Chem, Eur J Med Chem, Bioorg Chem, Bioorg Med Chem等10余种期刊审稿人，任Frontiers in Molecular Biosciences和Molecules期刊客座编辑。受邀参加2018年第十四届中国药学会青年药学论坛及2019中国药物化学学术会议暨中欧药物化学研讨会青年论坛做分会报告，参加第六届《药学学报》药学前沿论坛暨第十五届中国药学会青年药学论坛做分会报告，并荣获青年优秀论文一等奖
研究领域
药物化学及药理学
(1) 靶向自噬关键靶标的抗肿瘤、抗帕金森小分子药物设计合成及作用机制研究
(2) 基于肿瘤耐药机制的多靶点药物设计合成及作用机制研究
(3) 已有药物的重定位研究及其新靶点和新机制的发现
近期论文
查看导师最新文章
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张岚, Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions, Acta Pharmaceutica Sinica B, 2022, 12(2):532- 557 (通讯作者), 2022 ( SCI )
张岚, Transcriptional cyclin-dependent kinases: Potential drug targets in cancer therapy, European Journal of Medicinal Chemistry, 2022, 229: 114056 (通讯作者), 2022 ( SCI )
张岚, Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy, Acta Pharmaceutica Sinica B DOI: 10.1016/j.apsb.2021.12.022 (通讯作者), 2022 ( SCI )
张岚, Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer, Cell Death & Disease, 2022, 13(4): 375. (通讯作者), 2022 ( SCI )
张岚, Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer, European Journal of Medicinal Chemistry, 2021, 210:113088 (通讯作者), 2021 ( SCI )
张岚, Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer, Journal of Medicinal Chemistry, 2021, 64(16):12022-12048 (通讯作者), 2021 ( SCI )
张岚, Recent advances in the design and discovery of synthetic tyrosinase inhibitors, European Journal of Medicinal Chemistry, 2021, 224: 113744 (通讯作者), 2021 ( SCI )
张岚, Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer, Journal of Medicinal Chemistry, 2021, 64(19): 14192-14216 (通讯作者), 2021 ( SCI )
张岚, Fam20C in Human Diseases: Emerging Biological Functions and Therapeutic Implications, Frontiers in Molecular Biosciences, 2021, 8: 790172 (通讯作者), 2021 ( SCI )
张岚, Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer, Theranostics, 2020, 10(18): 8080-8097 (通讯作者), 2020 ( SCI )
张岚, Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types, Journal of Medicinal Chemistry, 2020, 63: 3976-3995 (通讯作者), 2020 ( SCI )
张岚, Diarylheptanoid: A privileged structure in drug discovery, Fitoterapia, 2020, 142: 104490 (通讯作者), 2020 ( SCI )
张岚, Dual-target kinase drug design: Current strategies and future directions in cancer therapy, European Journal of Medicinal Chemistry, 2020, 188: 112025 (通讯作者), 2020 ( SCI )
张岚, Targeting autophagy-related protein kinases for potential therapeutic purpose, Acta Pharmaceutica Sinica B, 2020, 10(4): 569-581 (通讯作者), 2020 ( SCI )
张岚, Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer, European Journal of Medicinal Chemistry, 2020, 208: 112782 (通讯作者), 2020 ( SCI )
张岚, Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells, Bioorganic & Medicinal Chemistry Letters, 2019, 29(19): 126623 (通讯作者), 2019 ( SCI )
张岚, Targeting Autophagy with Small-Molecule Modulators in Immune-Related Diseases, Advances in Experimental Medicine and Biology, 2019, 1209:181-203 (第一作者), 2019 ( SCI )
张岚, 自噬启动因子ULK1的生物学功能与靶向治疗研究进展, 厦门大学学报(自然科学版), 2019, 58(6): 787-801 (第一作者), 2019
张岚, Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment, Journal of Medicinal Chemistry, 2018, 61(7):2776-2792 (共同第一作者), 2018 ( SCI )
张岚, UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target, Journal of Medicinal Chemistry, 2018, 61(15):6491-6500 (第一作者), 2018 ( SCI )
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