贺耘 - 重庆大学 - 药学院(创新药物研究中心)

个人简介

Professor, Chongqing University, China (2012-) Dean, School of Pharmaceutical Sciences, Chongqing University, China (2016-2021) Director, Innovative Drug Research Center, Chongqing University, China (2013-2021) Visiting Professor, Beijing University and SIMM (2011-2014) Sr. VP and CSO, BioDuro (Beijing), a PPD company (2008-2011) Sr. Director and member of Roche Global Chemistry Leadership Team, Roche R&D Center (China) (2006-2008) President and Board Director, SABPA San Diego (2005-2006) Associate Director, Genomic Research Institute of Novartis Foundation (GNF) (2001-2006) Group Leader, IONIS Pharmaceuticals (2000-2001) Chemist, Pharmaceutical Product Division, Abbott Labs (1991-1995) PhD Student, The Chinese University of Hong Kong (1988-1990) Ph.D., The Scripps Research Institute MS, Iowa State University MS, Lanzhou University BS, Southwest University

研究领域

Our lab focuses on natural product-based drug discovery of novel antibacterial and anticancer agents with clinical needs. It involves computer aided drug design (CADD), total synthesis, structure activity relationships (SAR) studies, drug delivery and chemical biology. 1. Total Synthesis and SAR Studies 2. Rational Drug Design, Synthesis and Biological Evaluation 3. Drug Delivery We take advantage of the biological characteristics of target cells to synthesize new materials and construct efficient drug delivery systems to facilitate drug transportation so that greater efficacy and better safety of drugs could be achieved. 4. Chemical Biology We employ the modern technologies, such as click chemistry, photoaffinity labeling, affinity chromatography, proteomics etc., to discover new drug targets and uncover biological mechanism, in support of drug discovery and development

近期论文

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S. Zhao, Z. P. Wang, Z. Lin, G. X. Wei, X. M. Wen, S. Y. Li, X. H. Yang, Q. Zhang, C. M. Jing, Y. W. Dai, J. Guo, Y. He, Drug Repurposing by Siderophore Conjugation: Synthesis and Biological Evaluation of Siderophore-Methotrexate Conjugates as Antibiotics, Angew. Chem. Int. Ed, Accepted. D. Huang, Q. W. Liu, M. J. Zhang, Y. Z. Guo,Z. Y. Cui, T. Li, D. Luo, B. Xu,C. Huang,J. Guo, Jian. K. Y. Tam, M. Zhang, S. L. Zhang, Y. He, A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities, J. Med. Chem, Accepted. X. H. Yang, Z. P. Wang, S. C. Xiang, D. Q. Wang, Y. Zhao, D. Luo, Y. F. Qiu, C. Huang, J. Guo, Y. W. Dai, S. L. Zhang, Y. He, Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity, J. Med. Chem, 2022, 65. 11, 8040-8061. DOI: 10.1021/acs.jmedchem.2c00615 C. P. Liu, J. X. Han, O. Marcelina, D. Nugrahaningrum, S. Huang, M. J. Zou, G. X. Wang, M. Makoto,Y. He,S. R. Wu, V. Kasim, Discovery of Salidroside-Derivated Glycoside Analogs as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia, J. Med. Chem, 2022, 65, 1, 135-162. DOI: 10.1021/acs.jmedchem.1c00947. H. B. Peng, B. B. Xie, J. J. Dai, Y. W. Dai, X. F. Cen, X. H. Yang, Y. He, GSH-Responsive Multifunctional Nanoparticles Based on Mannose-Modified Pillar[5]arene for Targeted Antibiotic Delivery against Intracellular MRSA. Mater. Chem. Front.,2022, 6, 360 , DOI: 10.1039/D1QM01459E B. B. Xie, Z. P. Wang, R. X. Zhang, Z. Zhang, Y. He, A SERS Aptasensor based on Porous Au-NC Nanoballoons for Bacteria Detection. Anal. Chim. Acta., 2022, 1190, 339175. DOI: 10.1016/j.aca.2021.339175 A. Nazli, D. He, H. C. Xu, Z. P. Wang, Y. He, A Comparative Insight on the Newly Emerging Rifamycins: Rifametane, Rifalazil, TNP-2092 and TNP-2198, Curr. Med. Chem., E-pub Abstract Ahead of Print, DOI:10.2174/0929867328666210806114949 B. B. Xie, X. H. Yang, R. X. Zhang, J. Guo, Z. C. Chen and Y. He, Hollow and Porous Fe3C-NC Nanoballoons Nanozymes for Cancer Cell H2O2 Detection, Sens. Actuators B Chem., 2021, 347, 130579, DOI: 10.1016/j.snb.2021.130597 H. Zhang, E. Wang, S. Geng, Z. Liu, Y. He, Q. Peng, Z. Feng, Experimental and Computational Studies of the Iron‐Catalyzed Selective and Controllable Defluorosilylation of Unactivated Aliphatic gem‐Difluoroalkenes. Angew. Chem. Int. Ed., 2021, 60, 10211-10218. DOI:10.1002/anie.202100049 B. B. Xie, H. B. Peng, R. X. Zhang, C. H. Wang, Y. He, A Label-Free Electrochemical Aptasensor Based on Stone-Like Gold Nanoparticles for Ultrasensitive Detection of Tetracycline, J. Phys. Chem. C., 2021, 125. 5678-5683. DOI:10.1021/acs.jpcc.0c10809 B. Xu, Z. P. Wang, Q. W. Liu, X. H. Yang, X. M. Li, D Huang, Y. F. Qiu, K. Y. Tam, S. L. Zhang and Y. He, Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity, Eur. J. Med. Chem., 2021, 214, 113225. DOI:10.1016/j.ejmech.2021.113225 P. F. Wang, Y. F. Qiu, Y. He, H. L. Zhu, Cyclin-dependent kinase 4/6 inhibitors for cancer therapy: a patent review (2015–2019), Expert. Opin. Ther. Pat., 2020, 30. 795-805. DOI:10.1080/13543776.2020.1825686 X. H. Yang, B. B. Xie, H. B. Peng, G. M. Shi, B. Sreenivas, Y. F. Qiu, C. H. Wang, Y. He, Mannose-modified Exosomes for Targeted Delivery of Lysostaphin and Vancomycin to Eradicate Intracellular MRSA, J. Control. Release, 2020, 329, 454-467.DOI:10.1016/j.jconrel.2020.11.045 H. C. Xu, A. Nazli, Z. P. Wang, Y. He, Bench-stable Imine Surrogates for the Efficient, One-pot and Catalytic Asymmetric Synthesis of α-Amino Esters/Ketones, Chem. Comm., 2020, 56, 14243-14246, DOI: 10.1039/D0CC06055K . X. Li, S. Chen, L. F. Zhang, Y. Zhang, X. H. Yang, B. B. Xie, J. Guo, Y. He, C. H. Wang, Inhalable functional mixed-polymer microspheres to enhance doxorubicin release behavior for lung cancer treatment, Colloid Surface B., 2020, 111350. DOI: 10.1016/j.colsurfb.2020.111350 S. Zhao, Z. P. Wang, X. M. Wen, S. Y. Li, G. X. Wei, J. Guo, Y. He, Synthesis of Vitamin B12-Antibiotic Conjugates with Improved Activity Against Gram-Negative Bacteria, Org. Lett., 2020, 16, 6632–6636, DOI:10.1021/acs.orglett.0c02403QQ图片20200908083731 X. Zeng, Y. Zhang, Z. Liu, S. Geng, Y. He, Z. Feng, Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C–O Bonds, Org. Lett., 2020, 22, 2950-2955. DOI:10.1021/acs.orglett.0c00679 S. Zhao, Z. L. Zhang, S. Y. Li, X. M. Wen, J. Guo, Y. He, Iridium-Catalyzed Cycloisomerization of N-Tethered 1,7-Enynes: Construction of Azabicyclo [5.1.0] octene System, J. Org. Chem., 2020. 85, 9321-9330. DOI:10.1021/acs.joc.0c00516 S. C. Xiang, D. Huang, Q. L. He, J. Li, K. Y. Tam, S. L. Zhang, Y. He, Development of Dual Inhibitors Targeting Pyruvate Dehydrogenase Kinases and Human Iactate Dehydrogenase A: High-throughput Virtual Screening, Synthesis and Biological Validations, Eur. J. Med. Chem., 2020, 1, 112579. DOI:10.1016/j.ejmech.2020.112579 H. B. Peng, B. B. Xie, X. H. Yang, J. J. Dai, G. X. Wei, Y. He, Pillar[5]arene-based, Dual pH and Enzyme Responsive Supramolecular Vesicles for Targeted Antibiotic Delivery Against Intracellular MRSA, Chem. Commun., 2020, 56, 8115-8118. DOI: 10.1039/D0CC02522D