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个人简介

教师简介 1.Education (A).Nov.2000-Sept.2004,SwissFederalInstituteofTechnology,Zürich(ETH),Switzerland AcademicDegree:Ph.D.,MajorinPhysicalchemistry/SolutionNMR; Thesis:PreparationandcharacterizationofmembraneproteinsandchallengingoligomericproteinsforsolutionNMRspectroscopy,2004(ETHZürich,DissertationNr.15726,url:http://e-collection.ethbib.ethz.ch/cgi-bin/show.pl?type=diss&nr=15726) (B).Sept.1998-Oct.2000,SchoolofPharmacy,UniversityofMarylandatBaltimore.U.S.A. PhDCandidate,MajorinPharmaceuticalSciences/DrugDiscoveryandDevelopment; (C).Sept.1995-July1998,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences. AcademicDegree:M.S.,MajorinOrganicChemistry/NaturalProductsChemistry; (D).Sept.1991-July1995,BeijingMedicalUniversity(PekingUniversityHealthScienceCenter). AcademicDegree:B.S.,MajorinPharmaceuticalSciences/Pharmaceutics. 2.PositionsandEmployment 2018.09-PrincipalInvestigator,InnovativeInstituteofChineseMedicineandPharmacy,ChengduUniversityofTCM 2012.03-PrincipalInvestigator,NMRgroup,KunmingInstituteofBotany,CAS 2009-2012.03AssistantScientist,NMRFAM,UniversityofWisconsin 2005-2008ResearchFellow,ProteinNuclearMagneticResonance,NIH,USA 2019.08-AdjunctFaculty,H.E.J.ResearchInstituteofChemistry,InternationalCenterforChemicalandBiologicalSciences,UniversityofKarachi,Parkistan 专利成果 1.中国,发明专利,联合使用不同核的一维核磁共振混合物定量方法(专利号:ZL2014104904876) 学术交流情况 1.2019,第一届中国生物物理学会代谢组学分会年会 2.2019,8thAsia-PacificNMRSymposium2019 招生专业 招生类型学院专业代码专业名称专业类型专业方向 硕士生命071000生物学学术型00.不区分研究方向 硕士生命100700药学学术型01.药物化学 硕士生命100700药学学术型05.药物分析学

研究领域

中药药效物质基础与作用机制,代谢组学,结构生物学, 核磁共振技术,液质联用技术 联合应用液态核磁共振技术和液质联用技术,采用代谢组学的研究手段和分析方法,系统地研究天然药物、中药成方制剂或单味制剂,发现、识别和挖掘其中发挥药效作用的化学物质;利用基于核磁共振的结构生物学的研究手段,研究天然药物发挥药效作用的化学物质与靶标蛋白相互作用的分子机制。

近期论文

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1.BinLiu,YanliChen,XiaofangMa,KaifengHu,Site-specificpeakintensityratio(SPIR)from1D2H/1HNMRspectraforrapiddistinctionbetweennaturalandsyntheticnicotineanddetectionofpossibleadulteration,AnalyticalandBioanalyticalChemistry,DOI:10.1007/s00216-019-02023-6.,2019(SCI) 2.XiaofangMa,BinLiu,JiahuiYang,,KaifengHu,,SolutionStructure,DynamicsandFunctionInvestigationofKringleDomainofHumanReceptorTyrosineKinase-likeOrphanReceptor1,JournalofBiomolecularStructure&Dynamics,DOI:10.1080/07391102.2019.1635914,2019(SCI) 3.XingLi,HuanLuo,TaoHuang,LiXu,XiaohuoShi,KaifengHu,StatisticallycorrelatingNMRspectraandLC-MSdatatofacilitatetheidentificationofindividualmetaboliteinmetabolomicsmixtures,,AnalyticalandBioanalyticalChemistry,411(7),1301-1309,2019(SCI) 4.TaoHuang,LinglingYu,XiaofangMa,KaifengHu,,Anadaptedisotopedilution1H-13Cheteronuclearsingle-quantumcorrelation(ID-HSQC)forrapidandaccuratequantificationofendogenousandexogenousplasmaglucose,AnalyticalandBioanalyticalChemistry,410(26),6705-6711,2018(SCI) 5.LinglingYu,ChaoWen,XingLi,ShiqiFang,LichuanYang,TonyWang,KaifengHu,,,SimultaneousquantificationofendogenousandexogenousplasmaglucosebyisotopedilutionLC-MS/MSwithindirectMRMofthederivativetag,AnalyticalandBioanalyticalChemistry,410(7),2011-2018.,2018(SCI) 6.ChaoWen,DongshanWang,XingLi,TaoHuang,ChengHuang,KaifengHu,,TargetedisolationandidentificationofbioactivecompoundsloweringcholesterolinthecrudeextractsofcrabapplesusingUPLC-DAD-MS-SPE/NMRbasedonpharmacology-guidedPLS-DA,JournalofPharmaceuticalandBiomedicalAnalysis,150,144-151.,2018(SCI)

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