个人简介

Ph.D. (1991) University of Chicago

研究领域

Bioanalytical/Chemical Biology/Structural Biology

PROTEIN STRUCTURE / FUNCTION RELATIONSHIPS; METABOLIC BIOCHEMISTRY The principle that guides my research is that biological macromolecules are chemicals and biological processes are chemical processes; we should be able to understand them using the tools and language of chemistry. REGULATION OF IRON-DEPENDENT REPRESSOR IN MYCOBACTERIUM TUBERCULOSIS: Cars would be pretty boring without regulatory mechanisms like gas pedals and brakes; proteins are the same. We are using a combination of physical methods to understand how iron binding activates this family of proteins for biological activity. The major questions focus on metal selectivity, coupling of metal-binding to protein structural re-arrangements and to DNA binding. METABOLIC BIOCHEMISTRY: Cells take in chemical energy in the form of sugars, fats, and amino acids. Metabolism represents the set of chemical transformations that obtain energy from these inputs either for immediate use or for storage. We are using a variety of methods to determine metabolic profiles for cells in specific states to determine how energy metabolism correlates with cell differentiation. Specifically, we are investigating how stem cells use chemical energy in the undifferentiated state and how this changes as the stem cells differentiate into specific tissue types.

近期论文

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Crowe Jason J.; Grant Samuel C.; Logan Timothy M.; et al. A magnetic resonance-compatible perfusion bioreactor system for three-dimensional human mesenchymal stem cell construct development. CHEMICAL ENGINEERING SCIENCE 2011, Volume: 66 Issue: 18, 4138-4147 Skelton, D (Skelton, David); Goodyear, A (Goodyear, Abbey); Ni, DQ (Ni, DaQun); Walton, WJ (Walton, Wendy J.); Rolle, M (Rolle, Myron);Hare, JT (Hare, Joan T.); Logan, TM (Logan, Timothy M.) Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells. JOURNAL OF BIOMOLECULAR NMR 2010, Volume: 48 Issue: 2, 93-102 Yang, F (Yang, Feng); Robotham, JM (Robotham, Jason M.); Grise, H (Grise, Henry); Frausto, S (Frausto, Stephen); Madan, V (Madan, Vanesa); Zayas, M (Zayas, Margarita); Bartenschlager, R (Bartenschlager, Ralf); Robinson, M (Robinson, Margaret); Greenstein, AE (Greenstein, Andrew E.); Nag, A (Nag, Anita); Logan, TM (Logan, Timothy M.); Bienkiewicz, E (Bienkiewicz, Ewa); Tang, H (Tang, Hengli)1 A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach. PLOS PATHOGENS 2010, Volume: 6 Issue: 9 Article Number: e1001118 Kogot, JM (Kogot, Joshua M.); Parker, AM (Parker, Alex M.); Lee, J (Lee, Jihun); Blaber, M (Blaber, Michael); Strouse, GF (Strouse, Geoffrey F.); Logan, TM (Logan, Timothy M.) Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF1-1.5 nm Au Nanoparticle Bioconjugate. BIOCONJUGATE CHEMISTRY 2009, Volume: 20 Issue: 11, 2106-2113 Kogot, JM (Kogot, Joshua M.); England, HJ (England, Hannah J.); Strouse, GF (Strouse, Geoffrey F.); Logan, TM (Logan, Timothy M.) Single Peptide Assembly onto a 1.5 nm Au Surface via a Histidine Tag. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2008, Volume: 130 Issue: 48, 16156-+