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个人简介

1999年7月获第四军医大学内科学感染病专业博士,先后在美国哈佛大学医学院等担任博士后和研究助理教授职位近十年,2009年5月回国。 获奖情况 2010年开封市优秀教师、2018年河南省教育厅科技进步二等奖、2018年中国侨界贡献二等奖

研究领域

PCNP与膈肌损伤保护、PCNP介导肿瘤调控机制及其药物研发

近期论文

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Wang DY#, Hong Y#, Chen YG, Dong PZ, Liu SY, Gao YR, Lu D, Li HM, Li T, Guo JC, He F, Ren XQ, Sun SY, Wu DD*, Duan SF*,Ji XY*. PEST-containing nuclear protein regulates cell proliferation, migration and invasion in lung adenocarcinoma. Oncogenesis,2019 Mar 14;8(3):22. doi: 10.1038/s41389-019-0132-4. Han Y-J,Ji X-Y*. Knockdown of LncRNA PVT1 inhibits glioma progression by regulating miR-424 expression. Oncology Research(SCI III, IF3.41),2019 Mar 4. doi: 10.3727/096504018X15424939990246. Wu DD, Wang DY, Li HM, Guo JC, Duan SF,Ji XY*. Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease. Oxid Med Cell Longev. 2019 Jan 20;2019:3831713. doi: 10.1155/2019/3831713. Ma L, Zeng Y, Wei J, Yang D, Ding G, Liu J, Shang J, Kang Y*,Ji X*. Knockdown of LOXL1 inhibits TGF-β1-induced proliferation and fibrogenesis of hepatic stellate cells by inhibition of Smad2/3 phosphorylation. Biomed Pharmacother. 2018 Nov;107:1728-1735. doi: 10.1016/j.biopha.2018.08.156. Epub 2018 Sep 10.PubMed PMID: 30257391. Hui Lu, Changshu Ke, Xiaofang Ni, Juanjuan Xiao, Ruijuan Xiu, Qin Tian, Huaxiong Pan, Ling Zou, Fei Wang, Tengfei Ma,Xinying Ji, Ping Yuan, Lin Liu, Jianmin Zhang, Wei Jia, Qiuhong Duan, Feng Zhu*.TOPK inhibits autophagy by phosphorylating ULK1 to promote chemoresistance in glioma cells.Submitted. Dong-Dong Wu, Shi-Yu Liu, Ying-Ran Gao, Dan Lu, Ya Hong, Ya-Ge Chen, Peng-Zhen Dong, Da-Yong Wang, Tao Li, Zhi-Guang Ren, Yuan-Fang Ma, Jian-Cheng Guo, Xue-Qun Ren, Shi-Yong Sun, Shao-Feng Duan *,Xin-Ying Ji *.Tumor necrosis factor-α-induced protein 8-like 2 is a molecular regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells. J Cell Mol Med, 2018(SCI II, IF4.59).2019 Jan 13. doi: 10.1111/jcmm.14065. [Epub ahead of print] PubMed PMID:30637920. Wang S, Zuo S, Liu Z,Ji X, Yao Z, Wang X. Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis. Biomed Pharmacother(SCI III, IF3.50). 2018 Jul 7; 106:813-820. doi: 10.1016/j.biopha.2018.07.021. [Epub ahead of print] PubMed PMID: 29990875. Han Y, Li X, Ma C,Ji X*, Li T, Zheng X, Zhang J, Yan J, Zhang D, Bai J. Seed Targeting with tiny anti-miR-1297 Inhibits EMT in melanoma cells. J Drug Target(SCI III, IF3.19). 2018 Jun 6:1-22. doi: 10.1080/1061186X.2018.1481412. [Epub ahead of print] PubMed PMID: 29873263. Guo-Yu Zhang# , Dan Lu#, Shao-Feng Duan#, Ying-Ran Gao, Shi-Yu Liu, Ya Hong, Peng-Zhen Dong, Ya-Ge Chen, Tao Li, Da-Yong Wang, Xiang-Shu Cheng, Fei He, Jian-She Wei, Guang-Yu Li, Qing-Yong Zhang, Dong-Dong Wu*,Xin-Ying Ji*. Hydrogen sulfide alleviates lipopolysaccharide-induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS/MAPK and TLR4/NF-κB signaling pathways. Oxidative Medicine and Cellular Longevity(SCI II, IF4.59). 2018 May 24;2018:9647809. doi: 10.1155/2018/9647809. eCollection 2018. PubMed PMID: 29977458; PubMed Central PMCID: PMC5994286. Wu DD,Gao YR,Li T,Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS*, Ji XY*. Pest-containing nuclear protein mediates the proliferation,migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR pathways. BMC Cancer(SCI III, IF3.39). 2018 May 2;18(1):499. doi:10.1186/s12885-018-4391-9. PubMed PMID: 29716528; PubMed Central PMCID: PMC5930684. Wu DD, Li T,Ji XY*.Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.J Immunol Res(IF 3.2,III区). 2017; 2017:3591248. doi: 10.1155/2017/3591248. Epub 2017 Sep 18. Wei W,Ji X,Guo X,Ji S.Regulatory Role of N6-methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases.J Cell Biochem.2017 Mar 3. doi: 10.1002/jcb.25967. Teng TS, Ji AL,Ji XY*, Li YZ. Neutrophils and Immunity: From Bactericidal Action to Being Conquered. J Immunol Res(IF 3.2,III区). 2017; 2017: 9671604. doi:10.1155/2017/9671604. Epub 2017 Feb 19. Review. PubMed PMID: 28299345; PubMed Central PMCID: PMC5337389. Qin WD, Liu GL, Wang J, Wang H, Zhang JN, Zhang F, Ma Y,Ji XY, Li C,Zhang MX*.Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis in diabetic cardiomyopathy.Oncotarget. 2016 Jun 14;7(24):35618-35631. Liu Z#, Li T#, Li P, Wei N, Zhao Z, Liang H,Ji X,Chen W, Xue M, Wei J. The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease. Oxid Med Cell Longev. 2015; 2015:352723. doi: 10.1155/2015/352723. Review. Tang Z, Baykal AT, Gao H, Quezada HC, Zhang H, Bereczki E, Serhatli M, Baykal B, Acioglu C, Wang S, Ioja E,Ji X, Zhang Y, Guan Z, Winblad B, Pei JJ. mTor is a signaling hub in cell survival: a mass-spectrometry-based proteomics investigation. J Proteome Res. 2014 May 2;13(5):2433-44.(IF 4.2,II区) Ying-Jie Ma#, Min He#, Ji-Ao Han, Li Yang,Xin-Ying Ji*(correspondence). A clinical study of HBsAg-activated dendritic cells and cytokine-induced killer cells during the treatment of chronic Hepatitis B. Scandinavian Journal of Immunology, 2013 Oct;78(4):387-93. Jingling Sun, Tengfei Chen,Xin-ying Ji(co-first),Changqin Liu, Praveen K. Yadav, Ruijin Wu, Pingchang Yang, Zhanju Liu. IL-25 downregulates Th1/Th17 immune response in an Il-10 dependent manner in inflammatory bowel diseases. Inflammatory Bowel Diseases. 2013 Mar-Apr; 19(4): 720-8. Jing Chen, Zhong-Dong Shi,Xin-Ying Ji,Jorge Morales, Jing-Wei Zhang, Navneet Kaur and Sihong Wang. Enhanced osteogenesis of human mesenchymal stem cells by periodic heat shock in self-assembling peptide hydrogel. Tissue Engineering Part A. 2013 Mar;19(5-6):716-28. Tang Z,Bereczki E,Zhang H,Wang S,Li C,Ji X,Branca RM,Lehtiö J,Guan Z,Filipcik P,Xu S,Winblad B,Pei JJ. Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis: IMPLICATION FOR ALZHEIMER DISEASE.J Biol Chem.2013 May 31; 288(22):15556-70.

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